STRUCTURE AND ANTIOXIDANT WCTIVITY ASSOCIWTIONS FOR MELATONIN MOLECULE AND ITS DERIVATIVTS
https://doi.org/10.51523/2708-6011.2011-8-1-22
Abstract
Structural and electronic properties of melatonin, tryptophan, and oxidative products of these molecules were determined theoretically by performing semi-empirical and ab initio calculations. The radical scavenging effects of melatonin and tryptophan were studied using the alkoxyl and peroxyl radical- generating systems. We have shown that melatonin, rather than tryptophan, is a potent lipid antioxidant and an effective scavenger of alkoxyl- and peroxyl radicals.
About the Authors
V. T. Cheshchevik
Instutute for Pharmacology and Biochemistry NAS Belarus
Belarus
Belarus
S. N. Sakolouskaya
Instutute for Pharmacology and Biochemistry NAS Belarus
Belarus
Belarus
E. A. Lapshina
Grodno State Agricultural University
Belarus
Belarus
S. N. Iljina
Grodno State Medical University
Belarus
Belarus
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Review
For citations:
Cheshchevik V.T., Sakolouskaya S.N., Lapshina E.A., Iljina S.N. STRUCTURE AND ANTIOXIDANT WCTIVITY ASSOCIWTIONS FOR MELATONIN MOLECULE AND ITS DERIVATIVTS. Health and Ecology Issues. 2011;(1):116-120. (In Russ.) https://doi.org/10.51523/2708-6011.2011-8-1-22
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