CORRELATION OF KI-67, BCL-2, P53 EXPRESSION WITH THE EVIDENCE OF IMMUNOHISTOCHEMICAL REACTION UNDER HERPETIC LESION IN WOMEN WITH HUMAN PAPILLOMAVIRUS OF CERVIX
https://doi.org/10.51523/2708-6011.2010-7-1s-12
Abstract
The analysis of the correlation of proliferation factor Ki-67 expression, anaptotic inhibitor bcl-2, mutant oncoprotein p53 with the evidence of immunohistochemical reaction under herpetic lesion in women with cervical HPV has been carried out under severe cervical intraepithelial neoplasia. It was established, that an evident expression of the antigens of herpes simplex virus type 2 are accompanied by the increase of proliferative activity under CIN III of cervix, whereas under a faintly evident positive reaction with herpes simplex virus type 2 a higher level of anaptotic inhibitor expression bcl-2 is observed.
About the Authors
O. V. Lesnichaya
Vitebsk State Medical University
Belarus
Belarus
D. M. Semyonov
Vitebsk State Medical University
Belarus
Belarus
Y. V. Krylov
Vitebsk Regional Clinical Pathological Bureau
Belarus
Belarus
References
1. Злокачественные новообразования в Беларуси / С. М. Поляков [и др.]; под ред. И. В. Малаховой, И. В. Залуцкого. - Мн.: РНПЦ М.Т., 2009. - 205 с.
2. Малярская, М. М. Проблема генитального герпеса в гинекологии и акушерстве / М. М. Малярская // Литобзор. - Москва, 1997 [Электронный ресурс]. - 1997 - Режим доступа: http://www.med2000.ru /perevod/article261.htm. - Дата доступа: 13.07.2007.
3. Руководство по иммуногистохимической диагностике опухолей человека / под ред. С. В. Петрова, Н. Г. Райхмана. - Казань., 2000. - 287 с.
4. Natural history of dysplasia of the uterine cervix / P. Holowaty [et al.] // J. Natl. Cancer. Inst. - 1999. - № 91(3). - P. 252-258.
5. Macnab, J. C. M. Herpes simplex virus and human cytomegalovirus: theor role in morphological transformation and genital cancers / J. C. M.Macnab // J. Gen. Virol. - 1987. - Vol. 68. - P. 2525-2550.
6. Wingo, P. A. Cancer Statistics / P. A. Wingo, Т. Tong, S. Bolden // CA Cancer J. Clin. - 1995. -Vol. 45. - P. 8-30.
Review
For citations:
Lesnichaya O.V., Semyonov D.M., Krylov Y.V. CORRELATION OF KI-67, BCL-2, P53 EXPRESSION WITH THE EVIDENCE OF IMMUNOHISTOCHEMICAL REACTION UNDER HERPETIC LESION IN WOMEN WITH HUMAN PAPILLOMAVIRUS OF CERVIX. Health and Ecology Issues. 2010;(1S):39-42. (In Russ.) https://doi.org/10.51523/2708-6011.2010-7-1s-12
Views: 216
Email this article 