FIRST EXPERIENCE OF THE DETECTION of the HPV Е6/Е7 ONCOPROTEINS EXPRESSION IN a PROPHYLACTIC EXAMINATION

Abstract

In the article there are investigation results of the HPV 16 Е6/Е7 oncoproteins, detected by means of colposcopy in the pathological samples of cervical epithelium, taken from 82 patients during prophylactic examinations. It has been ascertained, that of the examined women, 39,0 % are HPV positive, and 78,1 % reveal HPV in the clinically significant concentration, the HPV 16 predominates in each second. The HPV 16 Е6/Е7 oncoproteins expression was detected in 66,7 ± 12,2 % cases, which made up 12,2 % of the whole investigation group. In connection with this, the conclusions have been made, that it is reasonable to use colposcopy with the subsequent HPV investigation (HPV genotyping, evaluation of viral load level, detection of oncoproteins expression) during prophylactic examinations for diagnostics of subclinical forms of the HPV infection of the cervix. As each tenth of practically healthy women, having colposcopic features of the viral lesion of the cervical epithelium, due to the presence of the HPV 16 and synthesis of viral proteins in the cervical epithelium cells, possessing carcinogenic activity, is in the high risk group of the development of cervical cancer. Key words: prophylactic examination, HPV, Е6/Е7 oncoproteins.