INFLUENCE OF SULFASALAZINE ON A HOMEOSTASIS OF SYSTEM OF BLOOD AT PATIENTS WITH ULCERATIVE COLITIS
https://doi.org/10.51523/2708-6011.2010-7-4-15
Abstract
With use of a method flowing cytometry at 50 patients with ulcerative colitis influence of sulfasalazine on a homeostasis of system of blood depending on activity of N-atsetyltransferase 2 (NAT2) is studied. It is established, that in system of peripheral blood at patients with ulcerative colitis with rapid acetylator phenotype standard doses of sulfasalazine did not influence level pathological apoptosis. Thus apoptosis it was accompanied by modulation of inhibition influences of sulfasalazine on cellular proliferation by means of braking of a G1-phase of a cellular cycle. At slow acetylator phenotype standard doses of sulfasalazine initiated the tendency to interruption of pathological apoptosis. However decrease in survival rate of cells of peripheral blood owing to reception sulfasalazine at low activity of NAT2 at patients with ulcerative colitis occurred at the expense of blocking a S-phase of a cellular cycle and increase in formation of cells with micronuclei.
About the Authors
V. Y. Afonin
Research-and-Production Centre of Institute of Pharmacology and Biochemistry of National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
T. V. Satyrova
Gomel State Medical University
Belarus
Belarus
E. I. Mikhailova
Gomel State Medical University
Belarus
Belarus
References
1. Ulcerative Colitis: Diagnosis and Treatment / C. Robert [et al.] // Am. Fam. Physician. - 2007. - Vol. 76, № 9. - P. 1323-1330.
2. Farr, M. Effects of sulphasalazine on lymphocyte functions / M. Farr, P. A. Bacon // Inflammopharmacol. - 1993. - Vol. 2, № 3 - P. 315-321.
3. Punchard, N. A. Mechanism of action of 5-aminosalicylic acid / N. A Punchard, S. M. Greenfield, R. P. H. Thompson // Mediators of Inflammation. - 1992. - Vol. 1. - P. 151-165.
4. Основанный на доказательствах Европейский консенсус по диагностике и лечению язвенного колита / Нац. Группа по воспалительным заболеваниям кишечника Респ. Беларусь; редкол.: Ю. Х. Мараховский [и др.]. - Минск, 2008. - 216 с.
5. Therapeutic immunology / K. F. Austen [et al.] // Cambridge, Mass.: Blackwell Science. - 2001. - 672 p.
6. Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosis / M. Wadelius [et al.] // Pharmacogenetics. - 2000. - Vol. 10, № 1. - P. 35-41.
7. Dery, C. L. Agranulocytosis associated with sulfasalazine / C. L. Dery, T. L. Schwinghammer // Drug. Intell. Clin. Pharm. - 1988. - Vol. 22, № 2. - P. 139-142.
8. Mechanistic studies on genotoxicity and carcinogenicity of salicylazosulfapyridine an anti-inflammatory medicine / M. J. Iatropoulos [et al.] // Exp. Toxicol. Pathol. - 1997. - Vol. 49, № 1/2. - P. 15-28.
9. Witt, K. L. Induction of kinetochore positive and negative micronuclei in mouse bone marrow cells by salicylazosulfapyridine and sulfapyridine / K.L. Witt, R. Gudi, J. P. Bishop // Mutat. Res. - 1992. - Vol. 283, № 1. - P. 53-57.
Review
For citations:
Afonin V.Y., Satyrova T.V., Mikhailova E.I. INFLUENCE OF SULFASALAZINE ON A HOMEOSTASIS OF SYSTEM OF BLOOD AT PATIENTS WITH ULCERATIVE COLITIS. Health and Ecology Issues. 2010;(4):75-81. (In Russ.) https://doi.org/10.51523/2708-6011.2010-7-4-15
Views: 297
Email this article 