<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2010-7-1-8</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-911</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ В ГОЛОВНОМ МОЗГЕ У БОЛЬНЫХ ВИРУСНЫМ ГЕПАТИТОМ С (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>MORPHOLOGIC SIGNS OF HCV IN THE BRAIN OF INFECTED HUMANS (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Майбогин</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Majbogin</surname><given-names>A. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Гомельский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Gomel State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>28</day><month>03</month><year>2010</year></pub-date><volume>0</volume><issue>1</issue><fpage>36</fpage><lpage>38</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Майбогин А.М., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Майбогин А.М.</copyright-holder><copyright-holder xml:lang="en">Majbogin A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/911">https://journal.gsmu.by/jour/article/view/911</self-uri><abstract><p>Вирус гепатита С (HCV) может обладать нейротропизмом, а по современным данным - установлены участки его внепеченочной репликации, включая ЦНС. В статье проанализированы данные новейших исследований об особенностях функционального и морфологического проявления HCV-инфекции в головном мозге, а также приведены возможные направления дальнейших морфологических исследований, которые, однако, находятся пока на начальном этапе.</p></abstract><trans-abstract xml:lang="en"><p>HCV is likely to poses certain neurotropism and modern researches prove its possibility for extrahepatic translation, including. A review observes and summarizes contemporary data about functional and morphologic signs of HCV-infection on the human brain, and presents possible directions of further morphologic study, that is however remains on the initial stadium.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>HCV</kwd><kwd>квазивиды</kwd><kwd>головной мозг</kwd><kwd>морфология</kwd><kwd>HCV</kwd><kwd>quasispecias</kwd><kwd>brain</kwd><kwd>morphology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">The changing epidemiology of Hepatitis C virus infection in Europe / Juan I. Esteban [et al.] // Journal of Hepatology. - 2008. - Vol. 48. - P. 148-162.</mixed-citation><mixed-citation xml:lang="en">The changing epidemiology of Hepatitis C virus infection in Europe / Juan I. Esteban [et al.] // Journal of Hepatology. - 2008. - Vol. 48. - P. 148-162.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Identification of Unique Hepatitis C Virus Quasispecies in the Central Nervous System and Comparative Analysis of Internal Translational Efficiency of Brain, Liver, and Serum Variants./ Forton D. M [et al.] // Journal of Virology. - 2004. - Vol. 78(10). - P. 5170-5183.</mixed-citation><mixed-citation xml:lang="en">Identification of Unique Hepatitis C Virus Quasispecies in the Central Nervous System and Comparative Analysis of Internal Translational Efficiency of Brain, Liver, and Serum Variants./ Forton D. M [et al.] // Journal of Virology. - 2004. - Vol. 78(10). - P. 5170-5183.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Search for hepatitis C virus negative-strand RNA sequences and analysis of viral sequences in the central nervous system: evidence of replication. / M. J. Radkowski [et al.] // J. Virol. - 2002. - Vol. 76. - P. 600-608.</mixed-citation><mixed-citation xml:lang="en">Search for hepatitis C virus negative-strand RNA sequences and analysis of viral sequences in the central nervous system: evidence of replication. / M. J. Radkowski [et al.] // J. Virol. - 2002. - Vol. 76. - P. 600-608.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Evidence for a cerebral effect of the hepatitis C virus / D. M Forton [et al.] // Lancet. - 2006. - Vol. 358. - P. 38-39.</mixed-citation><mixed-citation xml:lang="en">Evidence for a cerebral effect of the hepatitis C virus / D. M Forton [et al.] // Lancet. - 2006. - Vol. 358. - P. 38-39.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cerebral dysfunction in chronic hepatitis C infection / D. M. Forton [et al.] // J. Viral Hepat. - 2003. - Vol. 10. - P. 81-86.</mixed-citation><mixed-citation xml:lang="en">Cerebral dysfunction in chronic hepatitis C infection / D. M. Forton [et al.] // J. Viral Hepat. - 2003. - Vol. 10. - P. 81-86.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Fulminant central nervous system demyelination associated with interferon-α therapy and hepatitis C infection / R. Höfbergen [et al.] // Multiple Sclerosis. - 2007. - Vol. 13. - P. 1100-1106.</mixed-citation><mixed-citation xml:lang="en">Fulminant central nervous system demyelination associated with interferon-α therapy and hepatitis C infection / R. Höfbergen [et al.] // Multiple Sclerosis. - 2007. - Vol. 13. - P. 1100-1106.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Leucoencephalopathy as rare complication of hepatitis C infection / R. Buccoliero [et al.] // Neurol. Science. - 2006. - Vol. 27. - P. 360-363.</mixed-citation><mixed-citation xml:lang="en">Leucoencephalopathy as rare complication of hepatitis C infection / R. Buccoliero [et al.] // Neurol. Science. - 2006. - Vol. 27. - P. 360-363.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Subclinical impairment of brain function in chronic hepatitis C infection / L. Kramer [et al.] // J. Hepatol. - 2002. - Vol. 37. - P. 349-354.</mixed-citation><mixed-citation xml:lang="en">Subclinical impairment of brain function in chronic hepatitis C infection / L. Kramer [et al.] // J. Hepatol. - 2002. - Vol. 37. - P. 349-354.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Brain hemorrhage as a complication of chronic hepatitis C virus related vasculitis / M. Elena Erro Aguirre [et al.] // J. Neurol. - 2008. - Vol. 255. - P. 944-945.</mixed-citation><mixed-citation xml:lang="en">Brain hemorrhage as a complication of chronic hepatitis C virus related vasculitis / M. Elena Erro Aguirre [et al.] // J. Neurol. - 2008. - Vol. 255. - P. 944-945.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Недзьведь, Г. К. О нозологической самостоятельности рассеянного склероза / Г. К. Недзьведь, М. К. Недзведь // Нейроиммунология. - 2003. - Т. 1-2. - С. 103-104.</mixed-citation><mixed-citation xml:lang="en">Недзьведь, Г. К. О нозологической самостоятельности рассеянного склероза / Г. К. Недзьведь, М. К. Недзведь // Нейроиммунология. - 2003. - Т. 1-2. - С. 103-104.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
