<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2009-6-4-1</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-875</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>СОВРЕМЕННЫЕ ПОДХОДЫ В ЛЕЧЕНИИ БОЛЬНЫХ МНОЖЕСТВЕННОЙ МИЕЛОМОЙ (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>MODERN APPROACHES IN TREATMENT OF PATIENTS OF MULTIPLE MYELOMES (references review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Искров</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Iskrov</surname><given-names>I. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Республиканский научно-практический центр радиационной медицины и экологии человека</institution></aff><aff xml:lang="en"><institution>Republican Scientifically-practical Centre of Radiating Medicine and Human Ecology</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2009</year></pub-date><volume>0</volume><issue>4</issue><fpage>7</fpage><lpage>12</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Искров И.А., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Искров И.А.</copyright-holder><copyright-holder xml:lang="en">Iskrov I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/875">https://journal.gsmu.by/jour/article/view/875</self-uri><abstract><p>Множественная миелома (ММ) является В-клеточной опухолью, которая характеризуется накоплением плазматических клеток в костном мозге.</p></abstract><trans-abstract xml:lang="en"><p>Multiple myelomes (MM) is the B-cellular tumor which is characterized by accumulation of plasmatic cells in bone morrow.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>множественная миелома</kwd><kwd>патогенез и лечение</kwd><kwd>Multiple myelomes</kwd><kwd>Pathogenesis and treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бессмельцев, С. С. Современные подходы к химиотерапии множественной миеломы / С. С. Бессмельцев // Медико-фармацевтический форум (29 окт. - 2 нояб.): тез. докл. - М., 2002. - С. 36-37.</mixed-citation><mixed-citation xml:lang="en">Бессмельцев, С. С. Современные подходы к химиотерапии множественной миеломы / С. С. Бессмельцев // Медико-фармацевтический форум (29 окт. - 2 нояб.): тез. докл. - М., 2002. - С. 36-37.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Blokhin, N. [et al.] // Ann NY Acad Sci. - 1958. - Vol. 68. - P. 1128-1132</mixed-citation><mixed-citation xml:lang="en">Blokhin, N. [et al.] // Ann NY Acad Sci. - 1958. - Vol. 68. - P. 1128-1132</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cancer Chemother.Rep. - 1962. - Vol. 21. - P. 87-99.</mixed-citation><mixed-citation xml:lang="en">Cancer Chemother.Rep. - 1962. - Vol. 21. - P. 87-99.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bergsagel, D. E. Some unusual manifestations of plasma cell neoplasma / D. E. Bergsagel, P. W. Pruzanski // Neoplastic disease of the Blood / Ed. P. H. Wiernik. - N.-Y., 1985. - P. 553-573.</mixed-citation><mixed-citation xml:lang="en">Bergsagel, D. E. Some unusual manifestations of plasma cell neoplasma / D. E. Bergsagel, P. W. Pruzanski // Neoplastic disease of the Blood / Ed. P. H. Wiernik. - N.-Y., 1985. - P. 553-573.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">A methodological evaluation of 15 controlled clinical trials in myelomatosis / H. S. Birgens [et al.] // Scand. J. Haematol. - 1985. - Vol. 35. - P. 26-34.</mixed-citation><mixed-citation xml:lang="en">A methodological evaluation of 15 controlled clinical trials in myelomatosis / H. S. Birgens [et al.] // Scand. J. Haematol. - 1985. - Vol. 35. - P. 26-34.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Peptichemio, vincristine, prednisone induction treatment in multiple myeloma / G. Merlini [et al.] // Tummori. - 1985. - Vol. 71. - P. 581-588.</mixed-citation><mixed-citation xml:lang="en">Peptichemio, vincristine, prednisone induction treatment in multiple myeloma / G. Merlini [et al.] // Tummori. - 1985. - Vol. 71. - P. 581-588.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Treatment of multiple myeloma in old patients / I. P. Palva [et al.] // Eur. J. Haematol. - 1989. - Vol. 43. - P. 328-331.</mixed-citation><mixed-citation xml:lang="en">Treatment of multiple myeloma in old patients / I. P. Palva [et al.] // Eur. J. Haematol. - 1989. - Vol. 43. - P. 328-331.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Treatment of multiple myeloma according to the extension of the disease: a prospective, randomised study comparing a less with a more aggressive cytostatic policy. Cooperative Group of Study and Treatment of Multiple myeloma / A. Riccardi [et al.] // Br. J. Cancer. - 1994. - Vol. 70. - P. 1203-1210.</mixed-citation><mixed-citation xml:lang="en">Treatment of multiple myeloma according to the extension of the disease: a prospective, randomised study comparing a less with a more aggressive cytostatic policy. Cooperative Group of Study and Treatment of Multiple myeloma / A. Riccardi [et al.] // Br. J. Cancer. - 1994. - Vol. 70. - P. 1203-1210.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Westin, J. Conventional chemotherapy in multiple myeloma / J. Westin // Pathol. Biol. (Paris). - 1999. - Vol. 47. - P. 169-171.</mixed-citation><mixed-citation xml:lang="en">Westin, J. Conventional chemotherapy in multiple myeloma / J. Westin // Pathol. Biol. (Paris). - 1999. - Vol. 47. - P. 169-171.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">The therapeutic efficacy of VBCMP-M2 protocol in multiple myeloma / M. D. Colovic [et al.] // Haematologica (Budap). - 1994. - Vol. 26. - P. 91-96.</mixed-citation><mixed-citation xml:lang="en">The therapeutic efficacy of VBCMP-M2 protocol in multiple myeloma / M. D. Colovic [et al.] // Haematologica (Budap). - 1994. - Vol. 26. - P. 91-96.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Complete remission induction with combined VBMCP chemotherapy and interferon in patients with multiple myeloma / M. M. Oken [et al.] // Leuk. Lymphoma. - 1996. - Vol. 20. - P. 447-452.</mixed-citation><mixed-citation xml:lang="en">Complete remission induction with combined VBMCP chemotherapy and interferon in patients with multiple myeloma / M. M. Oken [et al.] // Leuk. Lymphoma. - 1996. - Vol. 20. - P. 447-452.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Comparison of melphalan and prednisone with vincristine, carmustine, melphalan, cyclophosphamide, and prednisone in the treatment of multiple myeloma: results of Eastern Cooperative Oncology Group Study E2479 / M. M. Oken [et al.] // Cancer. - 1997. - Vol. 79. - P. 1561-1567.</mixed-citation><mixed-citation xml:lang="en">Comparison of melphalan and prednisone with vincristine, carmustine, melphalan, cyclophosphamide, and prednisone in the treatment of multiple myeloma: results of Eastern Cooperative Oncology Group Study E2479 / M. M. Oken [et al.] // Cancer. - 1997. - Vol. 79. - P. 1561-1567.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">McElwain, T. J. High-dose intravenous melphalan for plasma-cell leukaemia and myeloma / T. J. McElwain, R. L. Powles. - Lancet. - 1983. - Vol. 2. - P. 822-824.</mixed-citation><mixed-citation xml:lang="en">McElwain, T. J. High-dose intravenous melphalan for plasma-cell leukaemia and myeloma / T. J. McElwain, R. L. Powles. - Lancet. - 1983. - Vol. 2. - P. 822-824.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Multiple myeloma treated with high dose intravenous melphalan / P. J. Selby [et al.] // Br J Haematol. - 1987. - Vol. 66. - P. 55-62</mixed-citation><mixed-citation xml:lang="en">Multiple myeloma treated with high dose intravenous melphalan / P. J. Selby [et al.] // Br J Haematol. - 1987. - Vol. 66. - P. 55-62</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Barlogie, B. [et al.] // Blood. - 1987. - Vol. 70. - P. 869-872.</mixed-citation><mixed-citation xml:lang="en">Barlogie, B. [et al.] // Blood. - 1987. - Vol. 70. - P. 869-872.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Attal, M. [et al.] // N. Engl J Med. - 1996. - Vol. 335. - P. 91-97.</mixed-citation><mixed-citation xml:lang="en">Attal, M. [et al.] // N. Engl J Med. - 1996. - Vol. 335. - P. 91-97.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Child, J. A. [et al.] // Ibid. - 2003. - Vol. 348. - P. 1875-1883.</mixed-citation><mixed-citation xml:lang="en">Child, J. A. [et al.] // Ibid. - 2003. - Vol. 348. - P. 1875-1883.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Blade, J. [et al.] // Ibid. - 2001. - Vol. 98. - P. 815a.</mixed-citation><mixed-citation xml:lang="en">Blade, J. [et al.] // Ibid. - 2001. - Vol. 98. - P. 815a.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Intergroupe Francais du Myelome. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma / M. Attal [et al.] // N Engl J Med. - 1996. - Vol. 335. - P. 91-97.</mixed-citation><mixed-citation xml:lang="en">Intergroupe Francais du Myelome. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma / M. Attal [et al.] // N Engl J Med. - 1996. - Vol. 335. - P. 91-97.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
