zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2009-6-3-12zdor-853Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEПРОГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ УРОВНЯ ЭКСПРЕССИИ ЦИКЛИНОВ B1 И D1 ПРИ РАКЕ ЯИЧНИКОВPROGNOSTIC SIGNIFICANCE OF EXPRESSION OF CYCLINES B1 AND D1 IN CASE OF OVARIAN CARCINOMAШульгаА. В.ShulgaA. V.noemail@neicon.ruБасинскийВ. А.BasinskiV. A.noemail@neicon.ruСавицкийС. Э.SavickiS. E.noemail@neicon.ruГродненский государственный медицинский университетGrodno State Medical UniversityГродненская областная клиническая больницаGrodno Regional Clinical Hospital200928092009035761Copyright © Шульга А.В., Басинский В.А., Савицкий С.Э., 20092009Шульга А.В., Басинский В.А., Савицкий С.Э.Shulga A.V., Basinski V.A., Savicki S.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/853

Циклины - семейство регуляторных белков, контролирующих клеточный цикл. Наличие функциональных и структурных нарушений регуляторов клеточного цикла (циклинов и циклинзависимых киназ) доказано для новообразований различных локализаций. В 69 случаях первичного рака яичников с помощью иммуногистохимического метода изучена экспрессия циклинов В1 и D1. Выявлена зависимость пятилетней выживаемости и степени дифференцировки опухоли от уровня экспрессии циклинов D1, B1.

Cyclins are a family of regulatory proteins that play a key role in controlling the cell cycle. Abnormalities of cell cycle regulators, including cyclins and cyclin dependent kinases, have been reported in various malignant tumors. Expression of cyclin B1, D1 was investigated with immunohistochemical method in 69 cases of primary ovarian carcinoma. Five-year survival and degree of differentiation have been found to depend on сyclins D1, В1.

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The authors declare that there are no conflicts of interest present.