<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2018-15-1-3</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-5</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ФАКТОРЫ РЕАЛИЗАЦИИ ПАТОГЕННОГО ПОТЕНЦИАЛА HELICOBACTERPYLORI: ПЕРСОНИФИЦИРОВАННЫЕ ТЕХНОЛОГИИ ОЦЕНКИ ПРОЯВЛЕНИЙ, ЛАБОРАТОРНОЙ ДИАГНОСТИКИ И ПРОГНОЗА</article-title><trans-title-group xml:lang="en"><trans-title>MOLECULAR AND GENETIC FACTORS FOR REALIZATION OF THE PATHOGENIC POTENTIAL OF HELICOBACTER PYLORI: PERSONIFIED TECHNIQUES FOR ASSESSMENT OF MANIFESTATIONS, LABORATORY DIAGNOSIS AND PROGNOSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воропаев</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Voropaev</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Учреждение образования «Гомельский государственный медицинский университет»</institution></aff><aff xml:lang="en"><institution>Gomel State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>28</day><month>03</month><year>2018</year></pub-date><volume>0</volume><issue>1</issue><fpage>15</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Воропаев Е.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Воропаев Е.В.</copyright-holder><copyright-holder xml:lang="en">Voropaev E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/5">https://journal.gsmu.by/jour/article/view/5</self-uri><abstract><p>Представлен аналитический обзор об особенностях технологий оценки патогенетического потенциала бактерии Helicobacterpylori - этиологического агента ряда заболеваний желудочно-кишечного тракта. Основной упор сделан на современные молекулярно-генетические технологии, позволяющие оценить не только патогенный потенциал бактерии, но и особенности микробиоты желудка и генотип инфицированного человека-хозяина.</p></abstract><trans-abstract xml:lang="en"><p>The work presents an analytical review of features of techniques for assessment of the pathogenetic potential of Helicobacter pylori bacterium, an etiological agent of a number of gastrointestinal diseases. The main emphasis is laid on modern molecular and genetic techniques that make it possible to assess not only the pathogenic potential of the bacterium, but also the characteristics of the stomach microbiota and the infected human host`s genotype.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>молекулярно-генетические исследования</kwd><kwd>секвенирование</kwd><kwd>ДНК</kwd><kwd>метагеном</kwd><kwd>гастрит</kwd><kwd>язва и рак желудка</kwd><kwd>лабораторная диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Helicobacterpylori</kwd><kwd>Helicobacter pylori</kwd><kwd>molecular and genetic studies</kwd><kwd>sequencing</kwd><kwd>DNA</kwd><kwd>metagenomics</kwd><kwd>gastritis</kwd><kwd>stomach ulcer and stomach cancer</kwd><kwd>laboratory diagnostics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Akosua, A.A., Richard, O.A. / Journal of Pharmacy And Bioallied Sciences 2015 Jul-Sep; Vol. 7(3): P. 239-244. // Perspective: Does personalized medicine hold the future for medicine?</mixed-citation><mixed-citation xml:lang="en">Akosua, A.A., Richard, O.A. / Journal of Pharmacy And Bioallied Sciences 2015 Jul-Sep; Vol. 7(3): P. 239-244. // Perspective: Does personalized medicine hold the future for medicine?</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Asahi Momoyo / Momoyo Asahi [et al.] / Helicobacter pylori Caga Protein Can Be Tyrosine Phosphorylated in Gastric Epithelial Cells // Journal of Experimental Medicine 2000 Feb 21; Vol. 191(4): P. 593-602.</mixed-citation><mixed-citation xml:lang="en">Asahi Momoyo / Momoyo Asahi [et al.] / Helicobacter pylori Caga Protein Can Be Tyrosine Phosphorylated in Gastric Epithelial Cells // Journal of Experimental Medicine 2000 Feb 21; Vol. 191(4): P. 593-602.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bahnassy Abeer A. [et al.]: Cyclin A and cyclin D1 as significant colorectal cancer patients BMC Gastroenterology 2004, Vol. 4: P. 22.</mixed-citation><mixed-citation xml:lang="en">Bahnassy Abeer A. [et al.]: Cyclin A and cyclin D1 as significant colorectal cancer patients BMC Gastroenterology 2004, Vol. 4: P. 22.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Beltran-Anaya F.O. / F.O. Beltran-Anaya [et al.] BMC Gastroenterology 2014 Dec 24; Vol. 14: P. 223. // The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated with peptic ulcer and gastric cancer in Mexican population.</mixed-citation><mixed-citation xml:lang="en">Beltran-Anaya F.O. / F.O. Beltran-Anaya [et al.] BMC Gastroenterology 2014 Dec 24; Vol. 14: P. 223. // The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated with peptic ulcer and gastric cancer in Mexican population.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bentley D. R. / D. R. Bentley [et al.] (2008).// Accurate whole human genome sequencing using reversible terminator chemistry.Nature Vol. 456P. 53-59</mixed-citation><mixed-citation xml:lang="en">Bentley D. R. / D. R. Bentley [et al.] (2008).// Accurate whole human genome sequencing using reversible terminator chemistry.Nature Vol. 456P. 53-59</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Boyanova L. / Role of Helicobacter pylori virulence factors for iron acquisition from gastric epithelial cells of the host and impact on bacterial colonization. Future Microbiology. 2011 Aug; Vol. 6(8): P.843-846.</mixed-citation><mixed-citation xml:lang="en">Boyanova L. / Role of Helicobacter pylori virulence factors for iron acquisition from gastric epithelial cells of the host and impact on bacterial colonization. Future Microbiology. 2011 Aug; Vol. 6(8): P.843-846.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cheng-Yao Chen / Frontiers in Microbiology. 2014; Vol. 5: P. 305. // DNA polymerases drive DNA sequencing-by-synthesis technologies: both past and present.</mixed-citation><mixed-citation xml:lang="en">Cheng-Yao Chen / Frontiers in Microbiology. 2014; Vol. 5: P. 305. // DNA polymerases drive DNA sequencing-by-synthesis technologies: both past and present.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">D.M. Parkin, F. Bray, J. Ferlay, P. Pisani / Global cancer statistics 2002. // CA: A Cancer Journal for Clinicians Vol. 55 (2005) P. 74-108.</mixed-citation><mixed-citation xml:lang="en">D.M. Parkin, F. Bray, J. Ferlay, P. Pisani / Global cancer statistics 2002. // CA: A Cancer Journal for Clinicians Vol. 55 (2005) P. 74-108.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Delgado S. / S. Delgado [et al.] Microbiological survey of the human gastric ecosystem using culturing and pyrosequencing methods //Microbial Ecology 2013; Vol. 65:P. 763-772.</mixed-citation><mixed-citation xml:lang="en">Delgado S. / S. Delgado [et al.] Microbiological survey of the human gastric ecosystem using culturing and pyrosequencing methods //Microbial Ecology 2013; Vol. 65:P. 763-772.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Dorak M.T. / Real Time PCR (BIOS Advanced Methods) // M.T. Dorak. - Taylor &amp; Francis. - 2006. - 333 p.</mixed-citation><mixed-citation xml:lang="en">Dorak M.T. / Real Time PCR (BIOS Advanced Methods) // M.T. Dorak. - Taylor &amp; Francis. - 2006. - 333 p.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">F.P. Carter, T. Frankson, J. Pintard, B. Edgecombe / Seroprevalence of Helicobacter pylori infection in adults in the Bahamas // West Indian Medical Journal Vol. 60 (2011) P. 662- 665.</mixed-citation><mixed-citation xml:lang="en">F.P. Carter, T. Frankson, J. Pintard, B. Edgecombe / Seroprevalence of Helicobacter pylori infection in adults in the Bahamas // West Indian Medical Journal Vol. 60 (2011) P. 662- 665.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Fujimoto S. / S.Fujimoto [et al.] Helicobacter pylori BabA expression, gastric mucosal injury, and clinical outcome.// Clinical Gastroenterology and Hepatology 2007; Vol. 5: P. 49-58.</mixed-citation><mixed-citation xml:lang="en">Fujimoto S. / S.Fujimoto [et al.] Helicobacter pylori BabA expression, gastric mucosal injury, and clinical outcome.// Clinical Gastroenterology and Hepatology 2007; Vol. 5: P. 49-58.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Gerald Karp / (2007).Cell and Molecular Biology: Concepts and Experiments. // New York: Wiley. pp.148, 165-170, 624-664.</mixed-citation><mixed-citation xml:lang="en">Gerald Karp / (2007).Cell and Molecular Biology: Concepts and Experiments. // New York: Wiley. pp.148, 165-170, 624-664.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ginsburg, G.S., Willard, H.F. / Genomic and personalized medicine: Foundations and applications // Translational Research. 2009; Vol. 154(6): P. 277-287.</mixed-citation><mixed-citation xml:lang="en">Ginsburg, G.S., Willard, H.F. / Genomic and personalized medicine: Foundations and applications // Translational Research. 2009; Vol. 154(6): P. 277-287.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">International Human Genome Sequencing Consortium / Initial sequencing and analysis of the human genome // Nature (London)2001; Vol. 409: P. 860-921.</mixed-citation><mixed-citation xml:lang="en">International Human Genome Sequencing Consortium / Initial sequencing and analysis of the human genome // Nature (London)2001; Vol. 409: P. 860-921.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">J.M. Noto, R.M. Peek / Helicobacter pylori: an overview // Methods in Molecular Biology Vol. 921 (2012) P. 7-10.</mixed-citation><mixed-citation xml:lang="en">J.M. Noto, R.M. Peek / Helicobacter pylori: an overview // Methods in Molecular Biology Vol. 921 (2012) P. 7-10.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">J.R. Warren / Gastric pathology associated with Helicobacter pylori, Gastrointestinal Endoscopy Clinics of North America // 29 (2000) 705-751.</mixed-citation><mixed-citation xml:lang="en">J.R. Warren / Gastric pathology associated with Helicobacter pylori, Gastrointestinal Endoscopy Clinics of North America // 29 (2000) 705-751.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kieleczawa J. / Sequencing of difficult DNA templates. In Kieleczawa J. (ed): // DNA Sequencing: Optimizing the Process and Analysis. Sudbury, MA: Jones and Bartlett, 2005:27-34.</mixed-citation><mixed-citation xml:lang="en">Kieleczawa J. / Sequencing of difficult DNA templates. In Kieleczawa J. (ed): // DNA Sequencing: Optimizing the Process and Analysis. Sudbury, MA: Jones and Bartlett, 2005:27-34.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Klymiuk I. / I. Klymiuk [et al.] The Human Gastric Microbiome Is Predicated upon Infection with Helicobacter pylori. // Frontiers in Microbiology. 2017 Dec 14; Vol. 8: P. 2508.</mixed-citation><mixed-citation xml:lang="en">Klymiuk I. / I. Klymiuk [et al.] The Human Gastric Microbiome Is Predicated upon Infection with Helicobacter pylori. // Frontiers in Microbiology. 2017 Dec 14; Vol. 8: P. 2508.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kusters G. / G. Kusters [et al.] Pathogenesis of Helicobacter pylori Infection // Clinical Microbiology Reviews 2006 Jul; Vol. 19 (3): P. 449-490.</mixed-citation><mixed-citation xml:lang="en">Kusters G. / G. Kusters [et al.] Pathogenesis of Helicobacter pylori Infection // Clinical Microbiology Reviews 2006 Jul; Vol. 19 (3): P. 449-490.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Linz B. / B. Linz [et al.] / An African origin for the intimate association between humans and Helicobacter pylori // Nature Vol. 445 (2007) P. 915-918.</mixed-citation><mixed-citation xml:lang="en">Linz B. / B. Linz [et al.] / An African origin for the intimate association between humans and Helicobacter pylori // Nature Vol. 445 (2007) P. 915-918.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Liu L. / L. Liu [et al.] 2012. / Comparison of next-generation sequencing systems //Journal of Biomedicine and Biotechnology Vol. 2012: Article ID 251364.</mixed-citation><mixed-citation xml:lang="en">Liu L. / L. Liu [et al.] 2012. / Comparison of next-generation sequencing systems //Journal of Biomedicine and Biotechnology Vol. 2012: Article ID 251364.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lydia E. Wroblewski / E. Lydia Wroblewski [et al.] / Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk // Clinical Microbiology Reviews. 2010 Oct; 23(4): 713-739.</mixed-citation><mixed-citation xml:lang="en">Lydia E. Wroblewski / E. Lydia Wroblewski [et al.] / Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk // Clinical Microbiology Reviews. 2010 Oct; 23(4): 713-739.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Makarenko E.V. / E.V. Makarenko [et al.] Multiple Helicobacter pylori as peculiar feature in Belarusian рatients with duodenal ulcer // Digestive Diseases and Sciences 2003 Vol. 48, № 9: P. 1879.</mixed-citation><mixed-citation xml:lang="en">Makarenko E.V. / E.V. Makarenko [et al.] Multiple Helicobacter pylori as peculiar feature in Belarusian рatients with duodenal ulcer // Digestive Diseases and Sciences 2003 Vol. 48, № 9: P. 1879.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Malfertheiner P. / P. Malfertheiner [et al.] European Helicobacter and Microbiota Study Group and Consensus panel. / Gut. 2017 Jan; Vol. 66 (1): P. 6-30. Epub 2016 Oct 5. // Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report.</mixed-citation><mixed-citation xml:lang="en">Malfertheiner P. / P. Malfertheiner [et al.] European Helicobacter and Microbiota Study Group and Consensus panel. / Gut. 2017 Jan; Vol. 66 (1): P. 6-30. Epub 2016 Oct 5. // Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Maxam A.M., Gilbert W. / A new method for sequencing DNA. // Proceedings of the National Academy of Sciences USA. 1977; Vol. 74: P. 560-564.</mixed-citation><mixed-citation xml:lang="en">Maxam A.M., Gilbert W. / A new method for sequencing DNA. // Proceedings of the National Academy of Sciences USA. 1977; Vol. 74: P. 560-564.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Mobley H.L.T., Mendz G.L., Hazell S.L. // Washington (DC): ASM Press; 2001. Helicobacter pylori: Physiology and Genetics.</mixed-citation><mixed-citation xml:lang="en">Mobley H.L.T., Mendz G.L., Hazell S.L. // Washington (DC): ASM Press; 2001. Helicobacter pylori: Physiology and Genetics.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Muller A. / Multistep activation of the Helicobacter pylori effector CagA // Journal Of Clinical Investigation Vol. 122 (2012) P. 1192-1195.</mixed-citation><mixed-citation xml:lang="en">Muller A. / Multistep activation of the Helicobacter pylori effector CagA // Journal Of Clinical Investigation Vol. 122 (2012) P. 1192-1195.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Mullis K.B. / The polymerase chain reaction in an anemic mode: how to avoid cold oligodeoxyribonuclear fusion. // PCR Methods and Applications1991 Aug; Vol. 1(1):P.1-4.</mixed-citation><mixed-citation xml:lang="en">Mullis K.B. / The polymerase chain reaction in an anemic mode: how to avoid cold oligodeoxyribonuclear fusion. // PCR Methods and Applications1991 Aug; Vol. 1(1):P.1-4.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Nagini S. / Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention. // World Journal of Gastrointestinal Oncology. 2012; Vol. 4(7): P. 156-169.</mixed-citation><mixed-citation xml:lang="en">Nagini S. / Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention. // World Journal of Gastrointestinal Oncology. 2012; Vol. 4(7): P. 156-169.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Nardone G., Compare D. / The human gastric microbiota: Is it time to rethink the pathogenesis of stomach diseases? // United European Gastroenterology Journal. 2015 Jun; Vol. 3(3):P. 255-260.</mixed-citation><mixed-citation xml:lang="en">Nardone G., Compare D. / The human gastric microbiota: Is it time to rethink the pathogenesis of stomach diseases? // United European Gastroenterology Journal. 2015 Jun; Vol. 3(3):P. 255-260.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Nigg, E. A. Genome Instability in Cancer Development (Advances in Experimental Medicine and Biology) / E. A. Nigg. - Springer. - 2006. - 511 p.</mixed-citation><mixed-citation xml:lang="en">Nigg, E. A. Genome Instability in Cancer Development (Advances in Experimental Medicine and Biology) / E. A. Nigg. - Springer. - 2006. - 511 p.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Pincock S. / Nobel Prize winners Robin Warren and Barry Marshall. // Lancet. 2005 Oct P. 22-28.</mixed-citation><mixed-citation xml:lang="en">Pincock S. / Nobel Prize winners Robin Warren and Barry Marshall. // Lancet. 2005 Oct P. 22-28.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Poretsky R. [et al.] / (2014) Strengths and limitations of 16S rRNA gene amplicon sequencing in revealing temporal microbial community dynamics // PLoS ONE Vol. 9, e93827 doi:10.1371/ journal.pone.0093827.</mixed-citation><mixed-citation xml:lang="en">Poretsky R. [et al.] / (2014) Strengths and limitations of 16S rRNA gene amplicon sequencing in revealing temporal microbial community dynamics // PLoS ONE Vol. 9, e93827 doi:10.1371/ journal.pone.0093827.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Riny Janssen / Riny Janssen [et al.] Host-Pathogen Interactions in Campylobacter Infections: The Host Perspective // Clinical Microbiology Reviews. 2008 Jul; Vol. 21(3): P. 505-518.</mixed-citation><mixed-citation xml:lang="en">Riny Janssen / Riny Janssen [et al.] Host-Pathogen Interactions in Campylobacter Infections: The Host Perspective // Clinical Microbiology Reviews. 2008 Jul; Vol. 21(3): P. 505-518.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Roos S., Engstrand L., Jonsson H. / Lactobacillus gastricus sp. nov., Lactobacillus antri sp. nov., Lactobacillus kalixensis sp. nov. and Lactobacillus ultunensis sp. nov., isolated from human stomach mucosa.// International Journal of Systematic and Evolutionary Microbiology.2005; Vol. 55: P. 77-82.</mixed-citation><mixed-citation xml:lang="en">Roos S., Engstrand L., Jonsson H. / Lactobacillus gastricus sp. nov., Lactobacillus antri sp. nov., Lactobacillus kalixensis sp. nov. and Lactobacillus ultunensis sp. nov., isolated from human stomach mucosa.// International Journal of Systematic and Evolutionary Microbiology.2005; Vol. 55: P. 77-82.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Sanger F. / Determination of nucleotide sequences in DNA. // Bioscience Reports. 1981 Jan; Vol. 1(1): P. 3-18.</mixed-citation><mixed-citation xml:lang="en">Sanger F. / Determination of nucleotide sequences in DNA. // Bioscience Reports. 1981 Jan; Vol. 1(1): P. 3-18.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Schulz A. / Molecular Biology of Human Cancers // A. Schulz - Springer. - 2005. - 508 p.</mixed-citation><mixed-citation xml:lang="en">Schulz A. / Molecular Biology of Human Cancers // A. Schulz - Springer. - 2005. - 508 p.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Sheh Alexander, G. Fox. James / The role of the gastrointestinal microbiome in Helicobacter pylori pathogenesis // Gut Microbes. 2013 Nov 1; Vol. 4(6): P. 505-531.</mixed-citation><mixed-citation xml:lang="en">Sheh Alexander, G. Fox. James / The role of the gastrointestinal microbiome in Helicobacter pylori pathogenesis // Gut Microbes. 2013 Nov 1; Vol. 4(6): P. 505-531.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Smith L.M., [et al.] / L.M. Smith [et al.] Fluorescence detection in automated DNA sequence analysis. // Nature. 1986; Vol. 321: P. 674-679.</mixed-citation><mixed-citation xml:lang="en">Smith L.M., [et al.] / L.M. Smith [et al.] Fluorescence detection in automated DNA sequence analysis. // Nature. 1986; Vol. 321: P. 674-679.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Takahiro Uotani, David Y. Graham / Diagnosis of Helicobacter pylori using the rapid urease test /Annals of Translational Medicine 2015 Jan; 3(1): 9.</mixed-citation><mixed-citation xml:lang="en">Takahiro Uotani, David Y. Graham / Diagnosis of Helicobacter pylori using the rapid urease test /Annals of Translational Medicine 2015 Jan; 3(1): 9.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Van Doorn L.J. / van Doorn L.J. [et al.] Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. // Gastroenterology. 1998; Vol. 115: P. 58-66.</mixed-citation><mixed-citation xml:lang="en">Van Doorn L.J. / van Doorn L.J. [et al.] Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. // Gastroenterology. 1998; Vol. 115: P. 58-66.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Van Nhieu G.T. / G.T. Van Nhieu [et al.] Helicobacter pylori type IV secretion apparatus exploits b1 integrin in a novel RGD-independent manner // PLOS Pathogens Vol. 5 (2009) e1000684.</mixed-citation><mixed-citation xml:lang="en">Van Nhieu G.T. / G.T. Van Nhieu [et al.] Helicobacter pylori type IV secretion apparatus exploits b1 integrin in a novel RGD-independent manner // PLOS Pathogens Vol. 5 (2009) e1000684.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Venter J.C. / J.C. Venter [et al.] The sequence of the human genome // Science.2001; Vol. 291: P. 1304-1351.</mixed-citation><mixed-citation xml:lang="en">Venter J.C. / J.C. Venter [et al.] The sequence of the human genome // Science.2001; Vol. 291: P. 1304-1351.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Venter J.C., Beard A. / J. Craig Venter the biologist who led the for-profit effort to sequence the human genome shares his thoughts on commercializing science. // Harvard Business Review. 2014 Sep; Vol. 92 (9): P. 132.</mixed-citation><mixed-citation xml:lang="en">Venter J.C., Beard A. / J. Craig Venter the biologist who led the for-profit effort to sequence the human genome shares his thoughts on commercializing science. // Harvard Business Review. 2014 Sep; Vol. 92 (9): P. 132.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Wang A.Y., Peura D.A. / The prevalence and incidence of Helicobacter pylori associated peptic ulcer disease and upper gastrointestinal bleeding throughout the world // Gastrointestinal Endoscopy Clinics of North America Vol. 21 (2011): P. 613-635.</mixed-citation><mixed-citation xml:lang="en">Wang A.Y., Peura D.A. / The prevalence and incidence of Helicobacter pylori associated peptic ulcer disease and upper gastrointestinal bleeding throughout the world // Gastrointestinal Endoscopy Clinics of North America Vol. 21 (2011): P. 613-635.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Li-Li / Li-Li Wang [et al.] / Participation of microbiota in the development of gastric cancer // World Journal of Gastroenterology // 2014 May 7; Vol. 20 (17): P. 4948-4952.</mixed-citation><mixed-citation xml:lang="en">Wang Li-Li / Li-Li Wang [et al.] / Participation of microbiota in the development of gastric cancer // World Journal of Gastroenterology // 2014 May 7; Vol. 20 (17): P. 4948-4952.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Xu J., Czinn S.J., Blanchard T.G. / Maintenance of Helicobacter pylori cultures in agar stabs. // Helicobacter. 2010; Vol. 15: P. 477-480.</mixed-citation><mixed-citation xml:lang="en">Xu J., Czinn S.J., Blanchard T.G. / Maintenance of Helicobacter pylori cultures in agar stabs. // Helicobacter. 2010; Vol. 15: P. 477-480.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshio Yamaoka,Muhammad Miftahussurur / Expert Review of Gastroenterology and Hepatology // Helicobacter pylorivirulence genes and host genetic polymorphisms as risk factors for peptic ulcer disease 2015; Vol. 9 (12): P. 1535-1547.</mixed-citation><mixed-citation xml:lang="en">Yoshio Yamaoka,Muhammad Miftahussurur / Expert Review of Gastroenterology and Hepatology // Helicobacter pylorivirulence genes and host genetic polymorphisms as risk factors for peptic ulcer disease 2015; Vol. 9 (12): P. 1535-1547.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Yang / Yang Zhang [et al.] / Genome-wide DNA methylation profiles altered by Helicobacter pylori in gastric mucosa and blood leukocyte DNA // Oncotarget 2016 Jun Vol. 14; 7(24): P. 37132-37144.</mixed-citation><mixed-citation xml:lang="en">Zhang Yang / Yang Zhang [et al.] / Genome-wide DNA methylation profiles altered by Helicobacter pylori in gastric mucosa and blood leukocyte DNA // Oncotarget 2016 Jun Vol. 14; 7(24): P. 37132-37144.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
