zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2006-3-2-20zdor-446Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEТАУРИН И ЭТАНОЛ В ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЕ: ВОЗМОЖНЫЕ МЕХАНИЗМЫ ВЗАИМОДЕЙСТВИЯTAURINE AND ETHANOL IN CENTRAL NERVOUS SYSTEM: POSSIBLITY MECHANISMS INTERACTIONSШейбакВ. М.SheibakV. M.noemail@neicon.ruГродненский государственный медицинский университетGrodno State Medical University20062806200602103107Copyright © Шейбак В.М., 20062006Шейбак В.М.Sheibak V.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/446

Таурин является одной из наиболее распространенных аминокислот в ЦНС и играет важную роль в интеграции таких физиологических процессов, как осморегуляция, нейропротекция и нейромодуляция. Как таурин, так и этанол оказывают положительные аллостерические модуляторные эффекты на рецепторы глицина и ГАМК (хлоридные каналы), а также ингибиторные эффекты на другие лиганд- и потенциал-зависимые катионные каналы. Показано, что таурин может дозозависимым образом изменять двигательную активность, эффекты седации и мотивации, обусловленные введением этанола. Этанол увеличивает внеклеточные уровни таурина в ряде регионов мозга, что может быть результатом его усиленного транспорта через гематоэнцефалический барьер. Экзогенное введение таурина, его производных или аналогов снижает потребление этанола. Таким образом, система гомеостаза таурина в организме может быть важным модулятором эффектов этанола в ЦНС.

Taurine and ethanol have the positive allosteric modulatory effects on the glycine- and GABA-receptors (chloride canals) and inhibit other ligand- and voltage-dependent cation channels. Taurine may dose-dependent the ethanol-induced changes in locomotor activity, sedation and motivation. Ethanol raise the extracellular taurine levels in various brain regions, possible because of its enhanced transfer through the blood-brain barrier. Exogenous taurine, its derivatives and analogues decrease the ethanol consumption. Thus, the system of taurine homeostasis may serve as an important modulator of ethanol-induced effects in CNS.

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The authors declare that there are no conflicts of interest present.