zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2026-23-2-13zdor-2963Research ArticleСЛУЧАЙ ИЗ КЛИНИЧЕСКОЙ ПРАКТИКИCLINICAL CASESГемангиоэндотелиома селезенки: на примере секционного наблюдения с иммуногистохимическим подтверждениемHemangioendothelioma of the spleen: a case study of post-mortem observation with immunohistochemical confirmationhttps://orcid.org/0000-0002-3405-7668ТищенкоГ. В.TishchenkoG. V.

Тищенко Григорий Витальевич, к.м.н., доцент, доцент кафедры патологической анатомии

Гомель

Grigorii V. Tishchenko, Candidate of Medical Sciences, Associate Professor, Associate Professor at the Department of Pathological Anatomy

Gomel

dr.gregory.t@gmail.comhttps://orcid.org/0009-0007-6307-5818ШишинаН. Н.ShishinaN. N.

Шишина Наталья Николаевна, врач-патологоанатом патологоанатомического отделения общей патологии № 4

Гомель

Natalia N. Shishina, Pathologist at the Pathologicoanatomic Department of General Pathology

Gomel

dr.natalllia@gmail.comhttps://orcid.org/0000-0001-8934-0754РоговЮ. И.RogovYu. I.

Рогов Юрий Иванович, к.м.н., доцент, доцент кафедры патологической анатомии и судебной медицины с курсом повышения квалификации и переподготовки

Минск

Yuriy I. Rogov, Candidate of Medical Sciences, Associate Professor, Associate Professor at the Department of Pathological Anatomy and Forensic Medicine with the course of Advanced Training and Retraining

Minsk

rogov.kpa@tut.byhttps://orcid.org/0000-0002-0977-5481АчиновичС. Л.AchinovichS. L.

Ачинович Сергей Леонидович, к.м.н., доцент, заведующий патологоанатомическим отделением

Гомель

Siarchei L. Achinovich, Candidate of Medical Sciences, Head of the Pathologicoanatomic Department, Gomel Regional Clinical Oncology Center

Gomel

ser.achinowitch2017@yandex.ruhttps://orcid.org/0000-0003-4030-0668ТищенкоИ. А.TsishchankaI. A.

Тищенко Ирина Александровна, ассистент кафедры патологической анатомии

Гомель

Iryna A. Tsishchanka, Assistant at the Department of Pathological Anatomy

Gomel

irina.tishchenko0905@gmail.comГомельский государственный медицинский университетБеларусьGomel State Medical UniversityBelarusГомельское областное клиническое патологоанатомическое бюроБеларусьGomel Regional Clinical Pathoanatomical BureauBelarusБелорусский государственный медицинский университетБеларусьBelarusian State Medical UniversityBelarusГомельский областной клинический онкологический диспансерБеларусьBelarusian State Medical UniversityBelarus202605082026232107117Copyright © Тищенко Г.В., Шишина Н.Н., Рогов Ю.И., Ачинович С.Л., Тищенко И.А., 20262026Тищенко Г.В., Шишина Н.Н., Рогов Ю.И., Ачинович С.Л., Тищенко И.А.Tishchenko G.V., Shishina N.N., Rogov Y.I., Achinovich S.L., Tsishchanka I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/2963Цель исследования

Цель исследования. Представить клинико-морфологическое описание случая гемангиоэндотелиомы селезенки с метастазами в печень и проанализировать ее патоморфологические и иммуногистохимические характеристики с учетом современных диагностических и дифференциально-диагностических критериев.

Материалы и методы

Материалы и методы. Представлен случай эпителиоидной гемангиоэндотелиомы (ЭГЭ) селезенки с метастатическим поражением печени у женщины 73 лет, поступившей в стационар с жалобами на боли в левом подреберье, увеличение живота в объеме и желтуху.

Результаты

Результаты. При аутопсийном исследовании выявлено массивное новообразование (НО) селезенки размером 15×12×10 см с распространенными метастазами в печень. Гистологически НО характеризовалось двухфазным строением с наличием солидных гнезд эпителиоидных клеток и анастомозирующих сосудистых каналов. Иммуногистохимическое исследование (ИГХ) показало диффузную положительную экспрессию CD31, CD34 и ERG, подтверждающую эндотелиальную природу опухоли, с индексом пролиферации Ki-67 10–15 %.

Заключение

Заключение. Данное клиническое наблюдение демонстрирует типичные патоморфологические признаки ЭГЭ селезенки и подчеркивает важность комплексного ИГХ для дифференциальной диагностики редких сосудистых новообразований. Поздняя диагностика на стадии диссеминированного заболевания отражает неспецифический характер клинических проявлений и обуславливает неблагоприятный прогноз. Описание данного случая в русскоязычной медицинской литературе вносит важный вклад в практическое здравоохранение, учитывая крайнюю редкость данной патологии.

Objective

Objective. To provide a clinical and morphological description of a case of splenic hemangioendothelioma with liver metastases, and to analyze its pathomorphological and immunohistochemical characteristics in accordance with current diagnostic and differential diagnostic criteria.

Materials and methods

Materials and methods. A case of epithelioid hemangioendothelioma (EHE) of the spleen with metastatic liver involvement in a 73‐year‐old woman admitted to the hospital with complaints of left upper quadrant pain, abdominal distension, and jaundice was presented.

Results

Results. Post‐mortem examination revealed a massive splenic tumor measuring 15×12×10 cm, with widespread metastases to the liver. Histologically, the tumor was characterized with a biphasic pattern, featuring solid nests of epithelioid cells and anastomosing vascular channels. Immunohistochemical analysis demonstrated diffuse positive expression of CD31, CD34, and ERG, confirming the endothelial nature of the tumor, with a Ki‐67 proliferation index of 10–15%.

Conclusion

Conclusion. This clinical observation demonstrates typical pathomorphological features of epithelioid hemangioendothelioma of the spleen and underscores the importance of comprehensive immunohistochemical analysis for the differential diagnosis of rare vascular tumors. The late diagnosis at the stage of disseminated disease reflects the non‐specific nature of clinical manifestations and explains the poor prognosis. This case study contributes significantly to the Russian‐language medical literature, given the extreme rarity of this pathology.

гемангиоэндотелиомаселезенкаэпителиоидная гемангиоэндотелиомаметастазы в печеньиммуногистохимияCD31CD34ERGаутопсиясосудистые опухолиhemangioendotheliomaspleenepithelioid hemangioendotheliomaliver metastasesimmunohistochemistryCD31CD34ERGautopsyvascular tumorsReferencesMorgado de Abreu MAM, Ferreira CAA, Nai GA. Composite hemangioendothelioma: report of a rare neoplasm. An Bras Dermatol. 2025;100(5):501166. DOI: https://doi.org/10.1016/j.abd.2025.501166Morgado de Abreu MAM, Ferreira CAA, Nai GA. Composite hemangioendothelioma: report of a rare neoplasm. An Bras Dermatol. 2025;100(5):501166. DOI: https://doi.org/10.1016/j.abd.2025.501166Anderson WJ, Doyle LA. Updates from the 2020 World Health Organization Classification of Soft Tissue and Bone Tumours. Histopathology. 2021;78(5):644-657. DOI: https://doi.org/10.1111/his.14265Anderson WJ, Doyle LA. Updates from the 2020 World Health Organization Classification of Soft Tissue and Bone Tumours. Histopathology. 2021;78(5):644-657. DOI: https://doi.org/10.1111/his.14265Rosenbaum E, Jadeja B, Xu B, et al. Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets. Mod Pathol. 2020;33:591-602. DOI: https://doi.org/10.1038/s41379-019-0368-8Rosenbaum E, Jadeja B, Xu B, et al. Prognostic stratification of clinical and molecular epithelioid hemangioendothelioma subsets. Mod Pathol. 2020;33:591-602. DOI: https://doi.org/10.1038/s41379-019-0368-8Paulson KG, Ravi V, Rubin BP, Park M, Loggers ET, Cranmer LD, Wagner MJ. Incidence, demographics, and survival of malignant hemangioendothelioma in the United States. Cancer Med. 2023;12(14):15101-15106. DOI: https://doi.org/10.1002/cam4.6181Paulson KG, Ravi V, Rubin BP, Park M, Loggers ET, Cranmer LD, Wagner MJ. Incidence, demographics, and survival of malignant hemangioendothelioma in the United States. Cancer Med. 2023;12(14):15101-15106. DOI: https://doi.org/10.1002/cam4.6181Liu Z, He S. Epithelioid hemangioendothelioma: incidence, mortality, prognostic factors, and survival analysis using the surveillance, epidemiology, and end results database. J Oncol. 2022;2022:2349991. DOI: https://doi.org/10.1155/2022/2349991Liu Z, He S. Epithelioid hemangioendothelioma: incidence, mortality, prognostic factors, and survival analysis using the surveillance, epidemiology, and end results database. J Oncol. 2022;2022:2349991. DOI: https://doi.org/10.1155/2022/2349991Коробкова И.З., Дрёмин Д.А., Какалов С.М., Кирсань И.В., Скрынников И.С., Угримов А.А., Сорокин М.Н. Эпителиоидная гемангиоэндотелиома печени. Вестник рентгенологии и радиологии. 2019;100(6):372-378. DOI: https://doi.org/10.20862/0042-4676-2019-100-6-372-378Korobkova IZ, Dremin DA, Kakalov SM, Kirsan’ IV, Skrynnikov IS, Ugrimov AA, Sorokin MN. Hepatic Epithelioid Hemangioendothelioma. Journal of Radiology and Nuclear Medicine. 2019;100(6):372-378. (In Russ.). DOI: https://doi.org/10.20862/0042-4676-2019-100-6-372-378Zhang S, Liang Y, Yang Y, Guo L, Li W, Shi S. Clinicopathological features, risk model and prognosis of 115 cases of epithelioid hemangioendothelioma: A single-center study. Front Oncol. 2025;15:1577968. DOI: https://doi.org/10.3389/fonc.2025.1577968Zhang S, Liang Y, Yang Y, Guo L, Li W, Shi S. Clinicopathological features, risk model and prognosis of 115 cases of epithelioid hemangioendothelioma: A single-center study. Front Oncol. 2025;15:1577968. DOI: https://doi.org/10.3389/fonc.2025.1577968Scalora N, DeWane G, Drebot Y, Khan AA, Sinha S, Ghosh K, Robinson D, Cogswell P, Bellizzi AM, Snow AN, Breheny P, Chimenti MS, Tanas MR. EHE cell cultures are a platform for mechanistic and therapeutic investigation. Sci Rep. 2025;15:35516. DOI: https://doi.org/10.1038/s41598-025-19453-1Scalora N, DeWane G, Drebot Y, Khan AA, Sinha S, Ghosh K, Robinson D, Cogswell P, Bellizzi AM, Snow AN, Breheny P, Chimenti MS, Tanas MR. EHE cell cultures are a platform for mechanistic and therapeutic investigation. Sci Rep. 2025;15:35516. DOI: https://doi.org/10.1038/s41598-025-19453-1Driskill JH, Zheng Y, Wu BK, Wang L, Cai J, Rakheja D, et al. WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma. Genes Dev. 2021;35(7-8):495-511. DOI: https://doi.org/10.1101/gad.348221.120Driskill JH, Zheng Y, Wu BK, Wang L, Cai J, Rakheja D, et al. WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma. Genes Dev. 2021;35(7-8):495-511. DOI: https://doi.org/10.1101/gad.348221.120Errani C, Zhang L, Sung YS, Hajdu M, Singer S, Maki RG, Healey JH, Antonescu CR. A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosom Cancer. 2011;50(9):644-653. DOI: https://doi.org/10.1002/gcc.20886Errani C, Zhang L, Sung YS, Hajdu M, Singer S, Maki RG, Healey JH, Antonescu CR. A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. Genes Chromosom Cancer. 2011;50(9):644-653. DOI: https://doi.org/10.1002/gcc.20886Flucke U, Vogels RJC, de Saint Aubain Somerhausen N, Creytens DH, Riedl RG, van Gorp JM, et al. Epithelioid hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases. Diagn Pathol. 2014;9:131. DOI: https://doi.org/10.1186/1746-1596-9-131Flucke U, Vogels RJC, de Saint Aubain Somerhausen N, Creytens DH, Riedl RG, van Gorp JM, et al. Epithelioid hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases. Diagn Pathol. 2014;9:131. DOI: https://doi.org/10.1186/1746-1596-9-131Pimenta EM, Goyal A, Farber ON, Lilley E, Shyn PB, Wang J, Wagner MJ. Epithelioid Hemangioendothelioma: Treatment Landscape and Innovations for an Ultra-Rare Sarcoma. Curr Treat Options Oncol. 2025;26(6):516-523. DOI: https://doi.org/10.1007/s11864-025-01328-2Pimenta EM, Goyal A, Farber ON, Lilley E, Shyn PB, Wang J, Wagner MJ. Epithelioid Hemangioendothelioma: Treatment Landscape and Innovations for an Ultra-Rare Sarcoma. Curr Treat Options Oncol. 2025;26(6):516-523. DOI: https://doi.org/10.1007/s11864-025-01328-2Liu X, Yang P, Liu L, Si S, Zhou R, Liu T, et al. Long-term prognosis and treatment modalities of hepatic epithelioid hemangioendothelioma: a retrospective study of 228 patients. BMC Cancer. 2024;24:1285. DOI: https://doi.org/10.1186/s12885-024-13053-4Liu X, Yang P, Liu L, Si S, Zhou R, Liu T, et al. Long-term prognosis and treatment modalities of hepatic epithelioid hemangioendothelioma: a retrospective study of 228 patients. BMC Cancer. 2024;24:1285. DOI: https://doi.org/10.1186/s12885-024-13053-4Wu X, Li B, Zheng C, Hong T, He X. Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study. Eur J Med Res. 2019;24:16. DOI: https://doi.org/10.1186/s40001-019-0375-8Wu X, Li B, Zheng C, Hong T, He X. Clinical characteristics of epithelioid hemangioendothelioma: a single-center retrospective study. Eur J Med Res. 2019;24:16. DOI: https://doi.org/10.1186/s40001-019-0375-8Denolf M, Rappaport A, Delvaux S. Epithelioid Hemangioendothelioma of Spleen and Bone: A Case Report. J Belg Soc Radiol. 2024;108(1):64. DOI: https://doi.org/10.5334/jbsr.3600Denolf M, Rappaport A, Delvaux S. Epithelioid Hemangioendothelioma of Spleen and Bone: A Case Report. J Belg Soc Radiol. 2024;108(1):64. DOI: https://doi.org/10.5334/jbsr.3600Shibuya R, Matsuyama A, Shiba E, Harada H, Yabuki K, Hisaoka M. CAMTA1 is a useful immunohistochemical marker for diagnosing epithelioid haemangioendothelioma. Histopathology. 2015;67(6):827-835. DOI: https://doi.org/10.1111/his.12713Shibuya R, Matsuyama A, Shiba E, Harada H, Yabuki K, Hisaoka M. CAMTA1 is a useful immunohistochemical marker for diagnosing epithelioid haemangioendothelioma. Histopathology. 2015;67(6):827-835. DOI: https://doi.org/10.1111/his.12713Tansir G, Rastogi S, Barwad A, Yadav R, Shamim SA, Dhamija E, Pandey R, Garg R, Shrivastava S. Management and outcomes of advanced hemangioendothelioma at a medical oncology clinic in an Indian tertiary care center. Future Sci OA. 2023;8(10):FSO827. DOI: https://doi.org/10.2144/fsoa-2021-0132Tansir G, Rastogi S, Barwad A, Yadav R, Shamim SA, Dhamija E, Pandey R, Garg R, Shrivastava S. Management and outcomes of advanced hemangioendothelioma at a medical oncology clinic in an Indian tertiary care center. Future Sci OA. 2023;8(10):FSO827. DOI: https://doi.org/10.2144/fsoa-2021-0132Li X, Ma X, Hao J, Dong C, Wang Y. Primary splenic epithelioid hemangioendothelioma with diffuse metastases revealed by FDG PET/CT imaging: A case report. Medicine (Baltimore). 2021;100(13):e25065. DOI: https://doi.org/10.1097/MD.0000000000025065Li X, Ma X, Hao J, Dong C, Wang Y. Primary splenic epithelioid hemangioendothelioma with diffuse metastases revealed by FDG PET/CT imaging: A case report. Medicine (Baltimore). 2021;100(13):e25065. DOI: https://doi.org/10.1097/MD.0000000000025065Meng K, Yang X, Guo S, Tao J. Hepatic epithelioid hemangioendothelioma with TFE3 rearrangement: a case report and literature review. Front Oncol. 2025;15:1442233. DOI: https://doi.org/10.3389/fonc.2025.1442233Meng K, Yang X, Guo S, Tao J. Hepatic epithelioid hemangioendothelioma with TFE3 rearrangement: a case report and literature review. Front Oncol. 2025;15:1442233. DOI: https://doi.org/10.3389/fonc.2025.1442233Fotiadis C, Georgopoulos I, Stoidis C, Patapis P. Primary tumors of the spleen. Int J Biomed Sci. 2009;5(2):85-91.Fotiadis C, Georgopoulos I, Stoidis C, Patapis P. Primary tumors of the spleen. Int J Biomed Sci. 2009;5(2):85-91.Ramkumar S. Epithelioid Haemangioma of Bone: A case series and comprehensive literature review reappraising the diagnostic classification of all epithelioid vascular neoplasms of bone. Cureus. 2021;13(6):e15371. DOI: https://doi.org/10.7759/cureus.15371Ramkumar S. Epithelioid Haemangioma of Bone: A case series and comprehensive literature review reappraising the diagnostic classification of all epithelioid vascular neoplasms of bone. Cureus. 2021;13(6):e15371. DOI: https://doi.org/10.7759/cureus.15371Vasquez M, Ordóñez NG, English GW, Mackay B. Epithelioid hemangioendothelioma of soft tissue: report of a case with ultrastructural observations. Ultrastructural Pathology. 1998;22(1):73-78. DOI: https://doi.org/10.3109/01913129809032260Vasquez M, Ordóñez NG, English GW, Mackay B. Epithelioid hemangioendothelioma of soft tissue: report of a case with ultrastructural observations. Ultrastructural Pathology. 1998;22(1):73-78. DOI: https://doi.org/10.3109/01913129809032260Anderson T, Zhang L, Hameed M, Rusch V, Travis WD, Antonescu CR. Thoracic epithelioid malignant vascular tumors: a clinicopathologic study of 52 cases with emphasis on pathologic grading and molecular studies of WWTR1-CAMTA1 fusions. Am J Surg Pathol. 2015;39(1):132-139. DOI: https://doi.org/10.1097/PAS.0000000000000346Anderson T, Zhang L, Hameed M, Rusch V, Travis WD, Antonescu CR. Thoracic epithelioid malignant vascular tumors: a clinicopathologic study of 52 cases with emphasis on pathologic grading and molecular studies of WWTR1-CAMTA1 fusions. Am J Surg Pathol. 2015;39(1):132-139. DOI: https://doi.org/10.1097/PAS.0000000000000346Tan Y, Yang X, Dong C, Xiao Z, Zhang H, Wang Y. Diffuse hepatic epithelioid hemangioendothelioma with multiple splenic metastasis and delayed multifocal bone metastasis after liver transplantation on FDG PET/CT images: A case report. Medicine (Baltimore). 2018;97(22):e10728. DOI: https://doi.org/10.1097/MD.0000000000010728Tan Y, Yang X, Dong C, Xiao Z, Zhang H, Wang Y. Diffuse hepatic epithelioid hemangioendothelioma with multiple splenic metastasis and delayed multifocal bone metastasis after liver transplantation on FDG PET/CT images: A case report. Medicine (Baltimore). 2018;97(22):e10728. DOI: https://doi.org/10.1097/MD.0000000000010728Guo Q, Xue J, Xu L, Shi Z, Zhou B. The clinical features of epithelioid hemangioendothelioma in a Han Chinese population: A retrospective analysis. Medicine (Baltimore). 2017;96(26):e7345. DOI: https://doi.org/10.1097/MD.0000000000007345Guo Q, Xue J, Xu L, Shi Z, Zhou B. The clinical features of epithelioid hemangioendothelioma in a Han Chinese population: A retrospective analysis. Medicine (Baltimore). 2017;96(26):e7345. DOI: https://doi.org/10.1097/MD.0000000000007345Sardaro A, Bardoscia L, Petruzzelli MF, Portaluri M. Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumor. Oncol Rev. 2014;8(2):259. DOI: https://doi.org/10.4081/oncol.2014.259Sardaro A, Bardoscia L, Petruzzelli MF, Portaluri M. Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumor. Oncol Rev. 2014;8(2):259. DOI: https://doi.org/10.4081/oncol.2014.259Zhao J, Dang Y. Case report of misdiagnosis: a rare case of hepatic epithelioid hemangioendothelioma characterized primarily by fever. Front Oncol. 2025;15:1606872. DOI: https://doi.org/10.3389/fonc.2025.1606872Zhao J, Dang Y. Case report of misdiagnosis: a rare case of hepatic epithelioid hemangioendothelioma characterized primarily by fever. Front Oncol. 2025;15:1606872. DOI: https://doi.org/10.3389/fonc.2025.1606872Sawma T, Sultan A, Abdulmoneim S, Grotz T, Rosen CB, Taner T, Heimbach JK, Warner SG, Siontis BL, Ho TP, Robinson SI. Management and long-term outcomes of patients with hepatic epithelioid hemangioendothelioma. J Surg Oncol. 2024;130(5):1062-1069. DOI: https://doi.org/10.1002/jso.27807Sawma T, Sultan A, Abdulmoneim S, Grotz T, Rosen CB, Taner T, Heimbach JK, Warner SG, Siontis BL, Ho TP, Robinson SI. Management and long-term outcomes of patients with hepatic epithelioid hemangioendothelioma. J Surg Oncol. 2024;130(5):1062-1069. DOI: https://doi.org/10.1002/jso.27807Туманова У.Н., Дубова Е.А., Кармазановский Г.Г., Щёголев А.И., Степанова Ю.А. Гемангиома селезёнки (наблюдение из практики и обзор литературы). Диагностическая и интервенционная радиология. 2011;5(1):81-93. DOI: https://doi.org/10.20862/0042-4676-2011-5-1-81-93Tumanova UN, Dubova EA, Karmazanovskiy GG, Shchegolev AI, Stepanova YuA. Hemangioma of the spleen (clinical observation and literature review). Diagnostic and Interventional Radiology. 2011;5(1):81-93. (In Russ.). DOI: https://doi.org/10.20862/0042-4676-2011-5-1-81-93Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 1982;50(5):970-981. DOI: https://doi.org/10.1002/1097-0142(19820901)50:5<970::aid-cncr2820500527>3.0.co;2-zWeiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer. 1982;50(5):970-981. DOI: https://doi.org/10.1002/1097-0142(19820901)50:5<970::aid-cncr2820500527>3.0.co;2-zTsuneyoshi M, Dorfman HD, Bauer TW. Epithelioid hemangioendothelioma of bone. A clinicopathologic, ultrastructural, and immunohistochemical study. Am J Surg Pathol. 1986;10(11):754-764. DOI: https://doi.org/10.1097/00000478-198611000-00002Tsuneyoshi M, Dorfman HD, Bauer TW. Epithelioid hemangioendothelioma of bone. A clinicopathologic, ultrastructural, and immunohistochemical study. Am J Surg Pathol. 1986;10(11):754-764. DOI: https://doi.org/10.1097/00000478-198611000-00002Scoazec JY, Degott C, Reynes M, Benhamou JP, Feldmann G. Epithelioid hemangioendothelioma of the liver: an ultrastructural study. Hum Pathol. 1989;20(7):673-681. DOI: https://doi.org/10.1016/0046-8177(89)90155-xScoazec JY, Degott C, Reynes M, Benhamou JP, Feldmann G. Epithelioid hemangioendothelioma of the liver: an ultrastructural study. Hum Pathol. 1989;20(7):673-681. DOI: https://doi.org/10.1016/0046-8177(89)90155-xWang Z, Zhang L, Zhang B, Mu D, Cui K, Li S. Hemangioendothelioma arising from the spleen: A case report and literature review. Oncol Lett. 2015;9(1):209-212. DOI: https://doi.org/10.3892/ol.2014.2693Wang Z, Zhang L, Zhang B, Mu D, Cui K, Li S. Hemangioendothelioma arising from the spleen: A case report and literature review. Oncol Lett. 2015;9(1):209-212. DOI: https://doi.org/10.3892/ol.2014.2693Ji F, Liu Y, Shi J, Liu C, Fu S, Wang H, Ren B, Mi D, Gao S, Sun D. Single-cell transcriptome analysis reveals mesenchymal stem cells in cavernous hemangioma. Front. Cell Dev. Biol. 10:916045. DOI: https://doi.org/10.3389/fcell.2022.916045Ji F, Liu Y, Shi J, Liu C, Fu S, Wang H, Ren B, Mi D, Gao S, Sun D. Single-cell transcriptome analysis reveals mesenchymal stem cells in cavernous hemangioma. Front. Cell Dev. Biol. 10:916045. DOI: https://doi.org/10.3389/fcell.2022.916045Petronella P, Scorzelli M, Luise R, Iannaci G, Sapere P, Ferretti M, Costanzo RM, Freda F, Canonico S, Rossiello R. Primary thyroid angiosarcoma: an unusual localization. World J Surg Oncol. 2012;10:73. DOI: https://doi.org/10.1186/1477-7819-10-73Petronella P, Scorzelli M, Luise R, Iannaci G, Sapere P, Ferretti M, Costanzo RM, Freda F, Canonico S, Rossiello R. Primary thyroid angiosarcoma: an unusual localization. World J Surg Oncol. 2012;10:73. DOI: https://doi.org/10.1186/1477-7819-10-73

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