zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2026-23-1-02zdor-2950Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРоль вирусов герпеса 4, 6 и 7-го типов в формировании хронических болевых синдромов у детейRole of herpes viruses types 4, 6 and 7 in the formation of chronic pain syndromes in childrenhttps://orcid.org/0000-0002-3252-2626КостюкС. А.KostiukS. A.

Костюк Светлана Андреевна, д.м.н., профессор, заведующий лабораторией молекулярно-генетической диагностики

г. Минск 

Svetlana A. Kostiuk, Doctor of Medical Sciences, Professor, Head of the Molecular Genetic Diagnostics Laboratory 

Minsk 

s.kostiuk@mail.ruhttps://orcid.org/0000-0001-7010-3724ЖевнеронокИ. В.ZhevneronokI. V.

Жевнеронок Ирина Владимировна, к.м.н., доцент, ведущий научный сотрудник группы научной методологии и доказательной медицины 

г. Минск 

Irina V. Zhevneronok, Candidate of Medical Sciences, Associate Professor, Leading Researcher at the Scientific Methodology and Evidence-Based Medicine Group 

Minsk 

ira_jevner@tut.byhttps://orcid.org/0009-0007-9586-5048ЕмельяненкоА. А.YemelyanenkoA. A.

Емельяненко Анастасия Александровна, стажер младшего научного сотрудника лаборатории молекулярно-генетической диагностики 

г. Минск 

Anastasia A. Yemelyanenko, Junior Researcher Intern at the Molecular Genetic Diagnostics Laboratory, Research Institute of Clinical and Experimental Medicine 

Minsk 

ncoliseun@yandex.ruhttps://orcid.org/0000-0002-8917-6816РуденковаТ. В.RudenkovaT. V.

Руденкова Татьяна Владимировна, к.б.н., доцент, ведущий научный сотрудник лаборатории молекулярно-генетической диагностики 

г. Минск 

Tatiana V. Rudenkova, Candidate of Biological Sciences, Associate Professor, Leading Researcher at the Molecular Genetic Diagnostics Laboratory 

Minsk 

t.rudenkova@mail.ruhttps://orcid.org/0000-0001-7130-2776ПолуянО. С.PoluyanO. S.

Полуян Ольга Сергеевна, к.б.н., доцент, ведущий научный сотрудник лаборатории молекулярно-генетической диагностики 

г. Минск 

Olga S. Poluyan, Candidate of Biological Sciences, Associate Professor, Leading Researcher at the Molecular Genetic Diagnostics Laboratory 

Minsk 

olga.poluyan@mail.ruhttps://orcid.org/0000-0002-1394-433XЛямцеваА. К.LyamtsevaA. K.

Лямцева Анна Константиновна, младший научный сотрудник лаборатории молекулярно-генетической диагностики 

г. Минск 

Anna K. Lyamtseva, Junior Researcher at the Molecular Genetic Diagnostics Laboratory 

Minsk 

annaliamtsava@gmail.comhttps://orcid.org/0009-0000-5989-2590ТихоновД. Ю.TikhonovD. Yu.

Тихонов Дмитрий Юрьевич, заместитель председателя комитета по здравоохранению 

г. Минск 

Dmitry Yu. Tikhonov, Deputy Chairman of the Committee for Health 

Minsk 

Kz.zampred@minsk.gov.byhttps://orcid.org/0009-0008-5350-7549ЗеноваО. В.ZenovaO. V.

Зенова Оксана Васильевна, врач-эпидемиолог (заведующий) противоэпидемического отделения санитарно-эпидемиологического отдела 

г. Минск 

Oksana V. Zenova, Epidemiologist (Head) of the AntiEpidemic Department of the Sanitary and Epidemiological Division 

Minsk 

zenova@tut.byhttps://orcid.org/0009-0003-0733-8055БирулинаМ. Г.BirulinaM. G.

Бирулина Марина Григорьевна, врач-эпидемиолог противоэпидемического отделения санитарно-эпидемиологического отдела 

г. Минск 

Marina G. Birulina, Epidemiologist of the Anti-Epidemic Department of the Sanitary and Epidemiological Division 

Minsk 

vbi1979@mail.ruНаучно-исследовательский институт клинической и экспериментальной медицины УО «Белорусский государственный медицинский университет»Research Institute of Clinical and Experimental Medicine of Belarusian State Medical UniversityМинский городской исполнительный комитетMinsk City Executive CommitteeЦентр гигиены и эпидемиологии Первомайского района г. МинскаCenter for Hygiene and Epidemiology of the Pervomaisky District of Minsk2026160420262311627Copyright © Костюк С.А., Жевнеронок И.В., Емельяненко А.А., Руденкова Т.В., Полуян О.С., Лямцева А.К., Тихонов Д.Ю., Зенова О.В., Бирулина М.Г., 20262026Костюк С.А., Жевнеронок И.В., Емельяненко А.А., Руденкова Т.В., Полуян О.С., Лямцева А.К., Тихонов Д.Ю., Зенова О.В., Бирулина М.Г.Kostiuk S.A., Zhevneronok I.V., Yemelyanenko A.A., Rudenkova T.V., Poluyan O.S., Lyamtseva A.K., Tikhonov D.Y., Zenova O.V., Birulina M.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/2950

Вирусы герпеса человека 4, 6 и 7-го типов широко распространены среди детского населения и обладают уникальной способностью к пожизненной латентной персистенции с периодической реактивацией. В статье представлен аналитический обзор научной литературы, посвященной эпидемиологии, молекулярной биологии и клиническим проявлениям инфекций, вызванных вирусами герпеса человека 4, 6, 7-го типов, с акцентом на их роль в формировании хронических болевых синдромов у детей. Ключевыми механизмами участия герпесвирусов в генезе хронических болевых синдромов являются: индукция хронического системного и нейровоспаления с выработкой провоспалительных цитокинов; прямой нейротропизм; поддержание центральной сенситизации; запуск аутоиммунных реакций, ведущих к повреждению нервных структур; развитие висцеральной гиперчувствительности через молекулярную мимикрию. Вирусы герпеса человека 4, 6, 7-го типов при их персистенции и реактивации за счет поддержания состояния иммунной дисрегуляции и нейровоспаления создают биологическую основу для трансформации острой ноцицептивной боли в ноципластическую, характерную для формирования хронических болевых синдромов у детей.

Human herpes viruses types 4, 6, and 7 are widespread among children, and possess a unique ability for maintaining lifelong latent persistence with periodic reactivation. This article provides an analytical review of the scientific literature on epidemiology, molecular biology, and clinical manifestations of infections caused by human herpesviruses types 4, 6, and 7, with a focus on their role in formation of chronic pain syndromes in children. The key mechanisms of herpesvirus involvement in the genesis of chronic pain syndromes are induction of chronic systemic and neuroinflammation with production of proinflammatory cytokines; direct neurotropism; maintenance of central sensitization; triggering of autoimmune reactions leading to damage to nerve structures; development of visceral hypersensitivity through molecular mimicry. Human herpes viruses types 4, 6, and 7, when persistent and reactivated by maintaining a state of immune dysregulation and neuroinflammation, create a biological basis for the transformation of acute nociceptive pain into nociplastic pain, specific to the formation of chronic pain syndromes in children.

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The authors declare that there are no conflicts of interest present.