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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2026-23-2-12</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-2947</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Оценка эффективности лечения острой боли в раннем послеоперационном периоде у пациентов урологического профиля</article-title><trans-title-group xml:lang="en"><trans-title>Efficiency evaluation of acute pain treatment in the early postoperative period in urological patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5588-8153</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коньков</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Konkov</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коньков Сергей Валентинович, к.м.н., заведующий кафедрой анестезиологии и реаниматологии</p><p>Гомель</p></bio><bio xml:lang="en"><p>Sergey V. Konkov, Candidate of Medical Sciences, Head of thе Department of Anesthesiology and Resuscitation</p><p>Gomel</p></bio><email xlink:type="simple">konkov@tut.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0490-2581</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбачева</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbacheva</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горбачева Татьяна Ивановна, старший преподаватель кафедры анестезиологии и реаниматологии</p><p>Гомель</p></bio><bio xml:lang="en"><p>Tatyana I. Gorbacheva, Senior Lecturer at the Department of Anesthesiology and Resuscitation</p><p>Gomel</p></bio><email xlink:type="simple">tanchora1986@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-8144-8669</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткаченко</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkachenko</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ткаченко Олег Викторович, заведующий отделением анестезиологии и реанимации</p><p>Гомель</p></bio><bio xml:lang="en"><p> </p><p>Oleg V. Tkachenko, Head of Anesthesiology and Resuscitation Unit, Gomel City Clinical Hospital No. 2</p><p>Gomel</p></bio><email xlink:type="simple">oleg.tkachenko.2606@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-9689-8996</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Москаленко</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Moskalenko</surname><given-names>A. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москаленко Александр Олегович, врач анестезиологреаниматолог отделения анестезиологии и реанимации</p><p>Гомель</p></bio><bio xml:lang="en"><p>Aliaksandr O. Moskalenko, Anesthesiologist-Resuscitator at the Anesthesiology and Resuscitation Unit</p><p>Gomel</p></bio><email xlink:type="simple">aliaksandr.rf@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-9435-1657</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рог</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rog</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рог Татьяна Александровна, врач анестезиолог-реаниматолог отделения анестезиологии и реанимации</p><p>Гомель</p></bio><bio xml:lang="en"><p>Tatiana A. Rog, Anesthesiologist-Resuscitator at the Anesthesiology and Resuscitation Unit</p><p>Gomel</p></bio><email xlink:type="simple">belladonna3343@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-7745-9916</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Силич</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Silich</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Силич Гульнара Владимировна, врач анестезиологреаниматолог отделения анестезиологии и реанимации</p><p>Гомель</p></bio><bio xml:lang="en"><p>Gulnara V. Silich, Anesthesiologist-Resuscitator at the Anesthesiology and Resuscitation Unit</p><p>Gomel</p></bio><email xlink:type="simple">gulnara.silich@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Гомельский государственный медицинский университет</institution><country>Беларусь</country></aff><aff xml:lang="en"><institution>Gomel State Medical University</institution><country>Belarus</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Гомельская городская клиническая больница № 2</institution><country>Беларусь</country></aff><aff xml:lang="en"><institution>Gomel City Clinical Hospital № 2</institution><country>Belarus</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>05</day><month>08</month><year>2026</year></pub-date><volume>23</volume><issue>2</issue><fpage>100</fpage><lpage>106</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коньков С.В., Горбачева Т.И., Ткаченко О.В., Москаленко А.О., Рог Т.А., Силич Г.В., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Коньков С.В., Горбачева Т.И., Ткаченко О.В., Москаленко А.О., Рог Т.А., Силич Г.В.</copyright-holder><copyright-holder xml:lang="en">Konkov S.V., Gorbacheva T.I., Tkachenko O.V., Moskalenko A.O., Rog T.A., Silich G.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/2947">https://journal.gsmu.by/jour/article/view/2947</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Оценить эффективность применения адъювантной мультимодальной анальгезии (ММА) у пациентов урологического профиля в раннем послеоперационном периоде.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование были включены 80 пациентов с плановыми оперативными вмешательствами — чреспузырной либо трансуретральной аденомэктомией, трансуретральной резекцией образования мочевого пузыря, проходившими хирургическое лечение на базе учреждения здравоохранения «Гомельская городская клиническая больница № 2». Средний возраст пациентов составил 59,8±10,6 года у лиц мужского пола (n = 74), у 6 женщин средний возраст составил 57,4±7,2 года. Период исследования включал 2023–2025 гг. Оперативное вмешательство выполнялось в плановом порядке у пациентов урологического профиля в стадии ремиссии без сопутствующей патологии или с соматической сопутствующей патологией в стадии компенсации без нарушения работы внутренних органов, без признаков острого либо хронического инфицирования. В исследуемую группу было включено 40 человек. Пациентам данной группы проводилась спинальная анестезия с внутривенным болюсным введением кетамина в периоперационном периоде на фоне ММА нестероидными противовоспалительными препаратами (НПВП). В группу сравнения вошли 40 пациентов. Данной группе проводилась спинальная анестезия без дополнительного назначения кетамина на разрез и без ММА в послеоперационном периоде. Пациенты были сопоставимы по половому, массо-ростовому, нозологическому и функциональным признакам.</p></sec><sec><title>Результаты</title><p>Результаты. В ходе этого проспективного когортного исследования удалось добиться снижения суточной дозы опиоидных анальгетиков (промедола) с помощью адъюванта кетамина на 25 % при p &lt; 0,05, что позволило снизить болевую чувствительность по визуально-аналоговой шкале (ВАШ) на 43 % через 12 ч после оперативного вмешательства и достичь полной анальгезии через 24 ч на фоне спинальной анестезии по сравнению с группой, где кетамин не применялся.</p></sec><sec><title>Заключение</title><p>Заключение. Назначение превентивной анальгезии кетамина в периоперационном периоде с подобранными дозировками препаратов в течение суток после оперативного вмешательства является эффективной методикой анальгезии у возрастных пациентов урологического профиля.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. To evaluate efficency of applying adjuvant multimodal analgesia (MMA) in urological patients in the early postoperative period.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 80 patients with planned surgical interventions of transvesical or transurethral adenomectomy, transurethral resection of the bladder formation, who underwent surgical treatment at the Gomel City Clinical Hospital No. 2. The average age of patients was 59.8±10.6 years old for males (n=74) and the average age of 6 female patients was 57.4±7.2. The study period included 2023-2025. The study group included 40 people. The surgical intervention was performed on a planned basis in urological patients in remission without concomitant pathology or with somatic concomitant pathology in the compensation stage without disruption of the internal organs, and without signs of acute or chronic infection. The study group included 40 individuals. The patients of this group received spinal anesthesia and intravenous ketamine bolus administration prior to the surgical incision following MMA nonsteroidal anti-inflammatory drugs (NAID). The comparison group included 40 patients. This group received spinal anesthesia without additional ketamine administration on an incision, and without MMA in postoperative period. The patients were matched for gender, weight and height, nosological, and functional characteristics.</p></sec><sec><title>Results</title><p>Results. In this prospective cohort study, it was possible to achieve a 25% reduction in the daily dose of opioid analgesics (promedol) with the use of ketamine adjuvant at p&lt;0.05, which reduces pain sensitivity according to the visual analogue scale (VAS) by 43% after 12 hours after operative treatment, and achieve a complete analgesia after 24 hours against the background of spinal anesthesia in comparison with the group where ketamine was not used.</p></sec><sec><title>Conclusion</title><p>Conclusion. Administration of the preventive analgesia with ketamine in the perioperative period with selected drug dosages during the day after surgery is an effective method of analgesia in elderly patients with urological problems.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>адъювантная мультимодальная анальгезия</kwd><kwd>опиоидные анальгетики</kwd><kwd>кетамин</kwd><kwd>спинальная анестезия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>adjuvant multimodal analgesia</kwd><kwd>opioid analgesics</kwd><kwd>ketamine</kwd><kwd>spinal anesthesia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy PG. Obesity. In: Hemmings HC Jr, Hopkins PM, editors. Foundations of Anaesthesia, Basic and Clinical Sciences. London: Mosby; 2000. p. 703-711.</mixed-citation><mixed-citation xml:lang="en">Murphy PG. Obesity. In: Hemmings HC Jr, Hopkins PM, editors. Foundations of Anaesthesia, Basic and Clinical Sciences. London: Mosby; 2000. p. 703-711.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Овечкин АМ, Яворовский АГ. Безопиоидная аналгезия в хирургии : от теории к практике: руководство для врачей. Москва: ГЭОТАР-Медиа; 2024. 240 с.</mixed-citation><mixed-citation xml:lang="en">Ovechkin AM, Yavorovsky AG. Non-opioid analgesia in surgery: from theory to practice: a guide for doctors. Moscow: GEOTAR-Media; 2024. 240 p. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Постановление Министерства здравоохранения Республики Беларусь от 17 ноября 2023 г. № 172. [дата обращения 2025 апрель 24]. Режим доступа: https://pravo.by/document/?guid=12551&amp;p0=W22340719p</mixed-citation><mixed-citation xml:lang="en">Resolution of the Ministry of Health of the Republic of Belarus dated November 17, 2023 No. 172. [date of access 2025 May 10]. Available from: https://pravo.by/document/?guid=12551&amp;p0=W22340719p</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Elia N, Lysakowski C, Tramer MR. Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient controlled analgesia morphine offer advantages over morphine alone? Anesthesiology. 2005;103:1296-304. DOI: https://doi.org/10.1097/00000542-200512000-00025</mixed-citation><mixed-citation xml:lang="en">Elia N, Lysakowski C, Tramer MR. Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient controlled analgesia morphine offer advantages over morphine alone? Anesthesiology. 2005;103:1296-304. DOI: https://doi.org/10.1097/00000542-200512000-00025</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Moore R, Derry S, McQuay H, Wiffen PJ. Single dose oral analgesics for acute postoperative pain in adults. Cochrane Database Syst Rev. 2011;9:CD008659. DOI: https://doi.org/10.1002/14651858.cd008659.pub2</mixed-citation><mixed-citation xml:lang="en">Moore R, Derry S, McQuay H, Wiffen PJ. Single dose oral analgesics for acute postoperative pain in adults. Cochrane Database Syst Rev. 2011;9:CD008659. DOI: https://doi.org/10.1002/14651858.cd008659.pub2</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Tzortzopoulou A, McNicol E, Cepeda M, Carr DB, Schumann R. Single dose intravenous propacetamol or intravenous paracetamol for postoperative pain. Cochrane Database Syst Rev. 2011;10:CD007126. DOI: https://doi.org/10.1002/14651858.CD007126.pub2</mixed-citation><mixed-citation xml:lang="en">Tzortzopoulou A, McNicol E, Cepeda M, Carr DB, Schumann R. Single dose intravenous propacetamol or intravenous paracetamol for postoperative pain. Cochrane Database Syst Rev. 2011;10:CD007126. DOI: https://doi.org/10.1002/14651858.CD007126.pub2</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Aubrun F, Langeron O, Heitz D, Coriat P, Riouet B. Randomized, placebo-con- trolled study of the postoperative analgesic effects of ketoprofen after spinal fusion surgery. Acta Anaesthesiol Scand. 2000;44:934-939. DOI: https://doi.org/10.1034/j.1399-6576.2000.440807.x</mixed-citation><mixed-citation xml:lang="en">Aubrun F, Langeron O, Heitz D, Coriat P, Riouet B. Randomized, placebo-con- trolled study of the postoperative analgesic effects of ketoprofen after spinal fusion surgery. Acta Anaesthesiol Scand. 2000;44:934-939. DOI: https://doi.org/10.1034/j.1399-6576.2000.440807.x</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kinsella J, Moffat AC, Patrick JA, Prentice JW, McArdle CS, Kenny GN, et al. Ketorolac trometamol for postoperative analgesia after orthopaedic surgery. Br J Anaesth. 1992;69:19-22. DOI: https://doi.org/10.1093/bja/69.1.19</mixed-citation><mixed-citation xml:lang="en">Kinsella J, Moffat AC, Patrick JA, Prentice JW, McArdle CS, Kenny GN, et al. Ketorolac trometamol for postoperative analgesia after orthopaedic surgery. Br J Anaesth. 1992;69:19-22. DOI: https://doi.org/10.1093/bja/69.1.19</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">McNicol ED, Tzortzoloulou A, Cepeda MS, Francia MB, Farhat T, Schumann R. Single-dose intravenous paracetamol or propacetamol for prevention or treatment of postoperative pain: A systematic review and meta-analysis. Br J Anaesth. 2011;106:764-775. DOI: https://doi.org/10.1093/bja/aer107</mixed-citation><mixed-citation xml:lang="en">McNicol ED, Tzortzoloulou A, Cepeda MS, Francia MB, Farhat T, Schumann R. Single-dose intravenous paracetamol or propacetamol for prevention or treatment of postoperative pain: A systematic review and meta-analysis. Br J Anaesth. 2011;106:764-775. DOI: https://doi.org/10.1093/bja/aer107</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ong C, Seymour R, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010;110(4):1170-1179. DOI: https://doi.org/10.1213/ANE.0b013e3181cf9281</mixed-citation><mixed-citation xml:lang="en">Ong C, Seymour R, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010;110(4):1170-1179. DOI: https://doi.org/10.1213/ANE.0b013e3181cf9281</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Maund E, McDaid C, Rice S, Wright K, Jenkins B, Woolacott N. Paracetamol and selective and non-selective nonsteroidal antiinflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review. Br J Anaesth. 2011;106(3):292-297. DOI: https://doi.org/10.1093/bja/aeq406</mixed-citation><mixed-citation xml:lang="en">Maund E, McDaid C, Rice S, Wright K, Jenkins B, Woolacott N. Paracetamol and selective and non-selective nonsteroidal antiinflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review. Br J Anaesth. 2011;106(3):292-297. DOI: https://doi.org/10.1093/bja/aeq406</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Michelet D, Andreu-Gallien J, Bensalah T, Hilly J, Wood C, Nivoche Y, et al. A meta-analysis of the use of nonsteroidal antiinflammatory drugs for pediatric postoperative pain. Anesth Analg. 2012;114(2):393-406. DOI: https://doi.org/10.1213/ANE.0b013e31823d0b45</mixed-citation><mixed-citation xml:lang="en">Michelet D, Andreu-Gallien J, Bensalah T, Hilly J, Wood C, Nivoche Y, et al. A meta-analysis of the use of nonsteroidal antiinflammatory drugs for pediatric postoperative pain. Anesth Analg. 2012;114(2):393-406. DOI: https://doi.org/10.1213/ANE.0b013e31823d0b45</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Laulin J.-P, Maurette P, Rivat C. The role of ketamine in preventing fentanylunduced hyperalgesia and subsequent acute morphine tolerance. Anesth. Analg. 2002;94:1263-1269. DOI: https://doi.org/10.1097/00000539-200205000-00040</mixed-citation><mixed-citation xml:lang="en">Laulin J.-P, Maurette P, Rivat C. The role of ketamine in preventing fentanylunduced hyperalgesia and subsequent acute morphine tolerance. Anesth. Analg. 2002;94:1263-1269. DOI: https://doi.org/10.1097/00000539-200205000-00040</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Gottschalk A, Sharma S, Ford J. The role of the perioperative period in recurrence after cancer surgery. Anesth Analg. 2010;110:1636-1643. DOI: https://doi.org/10.1213/ANE.0b013e3181de0ab6</mixed-citation><mixed-citation xml:lang="en">Gottschalk A, Sharma S, Ford J. The role of the perioperative period in recurrence after cancer surgery. Anesth Analg. 2010;110:1636-1643. DOI: https://doi.org/10.1213/ANE.0b013e3181de0ab6</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts G, Bekker T, Carlsen H, Moffatt CH, Slattery PJ, McClure AF. Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a doserelated manner. Anesth Analg. 2005;101(5):1343-1348. DOI: https://doi.org/10.1213/01.ANE.0000180204.64588.EC</mixed-citation><mixed-citation xml:lang="en">Roberts G, Bekker T, Carlsen H, Moffatt CH, Slattery PJ, McClure AF. Postoperative nausea and vomiting are strongly influenced by postoperative opioid use in a doserelated manner. Anesth Analg. 2005;101(5):1343-1348. DOI: https://doi.org/10.1213/01.ANE.0000180204.64588.EC</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gagliese L, Gauthier L, Macpherson A, Jovellanos M, Chan VW. Correlates of postoperative pain and intravenous patient-controlled analgesia use in younger and older surgical patients. Pain Med. 2008; 9(3):299-314. DOI: https://doi.org/10.1111/j.1526-4637.2008.00426.x</mixed-citation><mixed-citation xml:lang="en">Gagliese L, Gauthier L, Macpherson A, Jovellanos M, Chan VW. Correlates of postoperative pain and intravenous patient-controlled analgesia use in younger and older surgical patients. Pain Med. 2008; 9(3):299-314. DOI: https://doi.org/10.1111/j.1526-4637.2008.00426.x</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Jarzyna D, Jungquist CR, Pasero C, Willens JS, Nisbet A, Oakes L, et al. American Society for Pain Management Nursing Guidelines on Monitoring for Opioid-Induced Sedation and Respiratory Depression. Pain Manag Nurs. 2011;12:118-145. DOI: https://doi.org/10.1016/j.pmn.2011.06.008</mixed-citation><mixed-citation xml:lang="en">Jarzyna D, Jungquist CR, Pasero C, Willens JS, Nisbet A, Oakes L, et al. American Society for Pain Management Nursing Guidelines on Monitoring for Opioid-Induced Sedation and Respiratory Depression. Pain Manag Nurs. 2011;12:118-145. DOI: https://doi.org/10.1016/j.pmn.2011.06.008</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bell R, Dahl J, Moore R, Kalso E. Perioperative ketamine for acute postoperative pain. Cochrane Database Syst Rev. 2006:CD004603. DOI: https://doi.org/10.1002/14651858.CD004603.pub2</mixed-citation><mixed-citation xml:lang="en">Bell R, Dahl J, Moore R, Kalso E. Perioperative ketamine for acute postoperative pain. Cochrane Database Syst Rev. 2006:CD004603. DOI: https://doi.org/10.1002/14651858.CD004603.pub2</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">McCartney C, Sinha A, Katz J. A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. Anesth Analg. 2004;98:1385-1400. DOI: https://doi.org/10.1213/01.ane.0000108501.57073.38</mixed-citation><mixed-citation xml:lang="en">McCartney C, Sinha A, Katz J. A qualitative systematic review of the role of N-methyl-D-aspartate receptor antagonists in preventive analgesia. Anesth Analg. 2004;98:1385-1400. DOI: https://doi.org/10.1213/01.ane.0000108501.57073.38</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Laskowski K, Stirling A, McKay W, Lim HJ. A systematic review of intravenous ketamine for postoperative analgesia. Can J Anaesth. 2011;58(10):911-923. DOI: https://doi.org/10.1007/s12630-011-9560-0</mixed-citation><mixed-citation xml:lang="en">Laskowski K, Stirling A, McKay W, Lim HJ. A systematic review of intravenous ketamine for postoperative analgesia. Can J Anaesth. 2011;58(10):911-923. DOI: https://doi.org/10.1007/s12630-011-9560-0</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
