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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2025-22-3-03</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-2892</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Характеристика клинических симптомокомплексов у молодых лиц (18–44 года) с постковидным синдромом</article-title><trans-title-group xml:lang="en"><trans-title>Characterization of clinical set of symptoms in young adults (18–44 years old) with post-COVID syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6951-928X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Репина</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Repina</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Репина Юлия Викторовна - старший преподаватель кафедры пропедевтики внутренних болезней.</p><p>Минск</p></bio><bio xml:lang="en"><p>Yuliya V. Repina - Senior Lecturer at the Department of Propaedeutics of Internal Diseases.</p><p>Minsk</p></bio><email xlink:type="simple">yulikost@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5252-340X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Доценко</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dotsenko</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p> </p><p>Доценко Эдуард Анатольевич - д.м.н., профессор, заведующий кафедрой пропедевтики внутренних болезней.</p><p>Минск</p></bio><bio xml:lang="en"><p>Eduard A. Dotsenko - Doctor of Medical Sciences, Professor, Head of the Department of Propaedeutics of Internal Diseases.</p><p>Minsk</p></bio><email xlink:type="simple">ed_dots@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9353-050X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шолкова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sholkava</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шолкова Мария Владимировна - к.м.н., доцент кафедры пропедевтики внутренних болезней.</p><p>Минск</p></bio><bio xml:lang="en"><p>Maryia V. Sholkava - Candidate of Medical Sciences, Associate Professor at the Department of Propaedeutics of Internal Diseases.</p><p>Minsk</p></bio><email xlink:type="simple">marusia_sha@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Белорусский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Belarusian State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2025</year></pub-date><volume>22</volume><issue>3</issue><fpage>24</fpage><lpage>31</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Репина Ю.В., Доценко Э.А., Шолкова М.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Репина Ю.В., Доценко Э.А., Шолкова М.В.</copyright-holder><copyright-holder xml:lang="en">Repina Y.V., Dotsenko E.A., Sholkava M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/2892">https://journal.gsmu.by/jour/article/view/2892</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Изучить структуру клинических симптомокомплексов постковидного синдрома (ПКС) у лиц молодого возраста (18–44 лет).</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включены 263 пациента в возрасте от 18 до 44 лет, перенесших COVID-19 в 2020–2024 гг. с длительностью симптомов более трех месяцев. Всем участникам было предложено заполнить валидированный «Вопросник самооценки здоровья после COVID-19». Статистический анализ включал оценку синдромной нагрузки, парных и множественных сочетаний симптомокомплексов, а также расчет условных вероятностей и коэффициентов корреляции. Обработка данных выполнена с использованием StatTech, v.4.8.5 и Python 3.12.</p></sec><sec><title>Результаты</title><p>Результаты. В исследуемой группе пациентов с ПКС (n = 263) женщины составили 69,2 % (n = 182).</p><p>Отмечен высокий уровень мультисистемных проявлений: в среднем 4,7±2,1 симптомокомплекса на одного пациента. Наиболее частыми были неврологический (86,3 %), кардиоваскулярный (61,2 %) и отоларингологический (60,8 %) симптомокомплексы. Полисистемные формы (≥ 4 симптомокомплекса) отмечены у 72,6 % пациентов, а выраженная мультисистемность (≥ 6) — у 38,4 %. У женщин «синдромная нагрузка» была выше, чем у мужчин (р &lt; 0,001). Часто выявлялись устойчивые комбинации симптомов, особенно с участием неврологических и психоэмоциональных компонентов (r = 0,321; p &lt; 0,05).</p></sec><sec><title>Заключение</title><p>Заключение. ПКС у лиц молодого возраста характеризуется высоким уровнем мультисистемности, с доминированием неврологических и кардиоваскулярных симптомов. Полученные данные подчеркивают необходимость комплексного подхода к диагностике и реабилитации даже в относительно благополучной возрастной группе.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. To study the structure of clinical set of symptoms in post-COVID syndrome among young adults (18–44 years old).</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 263 patients at the ages from 18 to 44 years old recovered from COVID-19 in 2020-2024 with duration of symptoms more than three months. All participants were proposed to fill a validated “Post-COVID-19 Health Self-Assessment Questionnaire”. A statistical analysis included assessment of symptom burden, pairwise and multiple combinations of the set of symptoms, as well as calculation of conditional probabilities and correlation coefficients. Data processing were done using StatTech v.4.8.5 and Python 3.12.</p></sec><sec><title>Results</title><p>Results. Women accounted for 69,2% (n=182) in the studied group of patients with post-COVID syndrome (n=263).</p><p>A high level of multisystem manifestation was observed, with an average of 4,7 ± 2,1 set of symptoms per one patient. The most frequent sets of symptoms were neurological (86.3%), cardiovascular (61.2%), and otolaryngological (60.8%) ones. Polysystem forms (≥4 sets of symptoms) were identified in 72.6% of patients, and extensive multisystemity (≥6) in 38.4%. Women demonstrated a significantly higher symptoms burden than men (p&lt;0.001). Stable symptom combinations were commonly observed, particularly those involving neurological and psycho-emotional components (r=0.321; p&lt;0.05).</p></sec><sec><title>Conclusion</title><p>Conclusion. Post-COVID syndrome in young adults is characterised by a high degree of multisystem involvement, with neurological and cardiovascular symptoms predominating. These findings highlight the need for a comprehensive approach to diagnosis and rehabilitation, even in a relatively safe age group.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>постковидный синдром</kwd><kwd>молодые взрослые</kwd><kwd>мультисистемность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>post-COVID syndrome</kwd><kwd>young adults</kwd><kwd>multisystem involvement</kwd><kwd>symptom complex</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках ГНТП «Научно-техническое обеспечение качества и доступности медицинских услуг» на 2023-2025 годы: «Разработать метод определения вероятности постковидного синдрома (U09.9 – состояние после COVID-19)», рег. № НИОКТР 20231573</funding-statement><funding-statement xml:lang="en">This work was carried out within the State Scientific and Technical Program “Scientific and Technical Support for the Quality and Accessibility of Medical Services” for 2023-2025: “Development of a method for determining the probability of post-COVID syndrome (U09.9 – post COVID-19 condition)” Registration No. 20231573</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Soriano JB, Murthy S, Marshall JC, Relan P, Diaz JV. 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