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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2024-21-2-07</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-2720</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Анализ основных статистических показателей и результатов лечения злокачественных новообразований полости носа и околоносовых пазух</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of the main statistical indicators and results of treatment of malignant neoplasms of the nasal cavity and paranasal sinuses</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1410-8392</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Marozava</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Морозова Наталья Алексеевна, врач онколог-хирург онкологического отделения опухолей головы и шеи</p><p> аг. Лесной, Минский район</p></bio><bio xml:lang="en"><p>Natalia A. Marozava, Oncologist-surgeon at the Oncology Department of Head and Neck Tumors</p><p>Minsk</p></bio><email xlink:type="simple">natalim-22@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3759-141X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колядич</surname><given-names>Ж. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaliadzich</surname><given-names>Zh. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Колядич Жанна Викторовна, д.м.н., профессор, заведующий лабораторией онкопатологии головы и шеи с группой онкопатологии центральной нервной системы</p><p>аг. Лесной, Минский район</p></bio><bio xml:lang="en"><p>Zhanna V. Kaliadzich, Doctor of Medical Sciences, Professor, Head of the Laboratory of Oncopathology of the Head and Neck with the Group of Oncopathology of the Central Nervous System </p><p>Minsk</p></bio><email xlink:type="simple">janept@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6335-1404</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евмененко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Evmenenko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Евмененко Алеся Александровна, к.б.н., специалист группы статистики и анализа отдела организации противораковой борьбы</p><p>аг. Лесной, Минский район</p></bio><bio xml:lang="en"><p>Alesya A. Evmenenko, Candidate of Biological Sciences, Specialist of the Statistics and Analysis Group at the Department of Organization of Anticancer Control</p><p>Minsk</p></bio><email xlink:type="simple">natalim-22@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Республиканский научно-практический центр онкологии и медицинской радиологии им. Н. Н. Александрова</institution></aff><aff xml:lang="en"><institution>N. N. Alexandrov National Cancer Centre</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>27</day><month>05</month><year>2024</year></pub-date><volume>21</volume><issue>2</issue><fpage>54</fpage><lpage>61</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Морозова Н.А., Колядич Ж.В., Евмененко А.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Морозова Н.А., Колядич Ж.В., Евмененко А.А.</copyright-holder><copyright-holder xml:lang="en">Marozava N.A., Kaliadzich Z.V., Evmenenko A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/2720">https://journal.gsmu.by/jour/article/view/2720</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Провести оценку основных статистических показателей злокачественных новообразований полости носа и околоносовых пазух в Республике Беларусь и анализ отдаленных результатов лечения пациентов с плоскоклеточным раком полости носа и околоносовых пазух.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Материалом эпидемиологического исследования послужили данные Белорусского канцер-регистра о 2 016 пациентах со злокачественными новообразованиями полости носа и околоносовых пазух (С30.0 и С31), выявленных за период 1998-2022 годы в Республике Беларусь.</p></sec><sec><title>Результаты</title><p>Результаты. Отношение смертности к заболеваемости злокачественными новообразованиями (ЗНО) полости носа (ПН) и околоносовых пазух (ОП) в Республике Беларусь составило 60 % в 2018–2022 гг. (в 1998–2002 гг. — 80 %). Частота диагностики в III–IV стадии — 73,8 % в 2018–2022 гг. Пятилетняя скорректированная выживаемость сократилась с 38,2±0,2 % в 2003 г. до 35,9±3,3 % в 2022 г. Доля III и IV стадий в группе плоскоклеточного рака, ассоциированного с синоназальной инвертированной папилломой, составила 69 %, в группе плоскоклеточного рака de novo — 89 % (р = 0,026). Пятилетняя скорректированная выживаемость пациентов с плоскоклеточным раком, ассоциированным с синоназальной инвертированной папилломой, составила 73,4 % (SE — 11,5 %), плоскоклеточным раком de novo — 38,7 % (SE — 5,1 %) (р = 0,012).</p></sec><sec><title>Заключение</title><p>Заключение. Высокие показатели отношения смертности к заболеваемости свидетельствуют о проблемах в диагностике и лечении ЗНО ПН и ОНП в Республике Беларусь. Группой риска заболевания ЗНО ПН и ОНП, требующей дополнительного медицинского наблюдения, является население в возрасте старше 40 лет.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. To assess the main statistical indicators of malignant neoplasms of the nasal cavity and paranasal sinuses in the Republic of Belarus, and analyze the long-term results of treating patients with squamous cell cancer of the nasal cavity and paranasal sinuses.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The material for the epidemiological study was the data from the Belarusian Cancer Registry on 2016 patients with malignant neoplasms of the nasal cavity and paranasal sinuses (C30.0 and C31), identified during the period of 1998-2022 in the Republic of Belarus.</p></sec><sec><title>Results</title><p>Results. The ratio of mortality to incidence of malignant neoplasms (MN) of the nasal cavity (CN) and paranasal sinuses (PS) in the Republic of Belarus was 60% in 2018-2022 (in 1998-2002 - 80%). The diagnosis rate in stages III-IV was 73.8% in 2018-2022. 5-year adjusted survival rate decreased from 38.2±0.2% in 2003 to 35.9±3.3% in 2022. The proportion of stages III and IV in the group of squamous cell carcinoma (SCC) associated with sinonasal inverted papilloma (SIP) was 69%, in the group of de novo SCC – 89% (p = 0.026). The 5-year adjusted survival (АS) of patients with SIP-associated SCC was 73.4% (SE 11.5%), de novo SCC was 38.7% (SE 5.1%) (p=0.012).</p></sec><sec><title>Conclusion</title><p>Conclusion. High mortality-to-morbidity ratios indicate problems in the diagnosis and treatment of malignant tumors of the PN and acute urinary tract in the Republic of Belarus. The risk group for developing cancer of the PN and PN, requiring additional medical supervision, is the population over the age of 40 years.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>злокачественные новообразования</kwd><kwd>полость носа и околоносовые пазухи</kwd><kwd>скорректированная выживаемость</kwd><kwd>плоскоклеточный рак</kwd><kwd>синоназальная инвертированная папиллома</kwd></kwd-group><kwd-group xml:lang="en"><kwd>malignant neoplasms</kwd><kwd>nasal cavity and paranasal sinuses</kwd><kwd>adjusted survival</kwd><kwd>squamous cell carcinoma</kwd><kwd>sinonasal inverted papilloma</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bracigliano A, Tatangelo F, Perri F, Di Lorenzo G, Tafuto R, Ottaiano A, et al. Malignant sinonasal tumors: update on histological and clinical management. Curr Oncol. 2021;28(4):2420-2438. 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