zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2023-20-4-01zdor-2637Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРадиационно-индуцированные изменения свойств и функций фибробластовRadiation-induced changes in the properties and functions of fibroblastshttps://orcid.org/0000-0001-9445-5513МатвеенковаТ. Д.MatveyenkavaT. D.

Матвеенкова Татьяна Дмитриевна, младший научный сотрудник лаборатории устойчивости биологических систем

Гомель

Tatiana D. Matveyenkava, Junior Researcher at the Labo- ratory of Stability of Biological Systems

Gomel

matveenkova.san@mail.ruhttps://orcid.org/0000-0003-1086-1675НазаренкоИ. В.NazarenkoI. V.

Назаренко Ирина Вячеславовна, к.м.н., доцент, декан медико-диагностического факультета, доцент кафедры лучевой диагностики, лучевой терапии с курсом ФПКиП

Гомель

Irina V. Nazarenko, Candidate of Medical Sciences, Dean of the Faculty of Medicine and Diagnostics, Associate Professor of the Department of Radiation Diagnostics, Radiation Therapy with course of the Faculty of Professional Development and Retraining

Gomel

irisha_n.91@mail.ruhttps://orcid.org/0000-0003-0808-183XЮрковскийА. М.YurkovskiyА. М.

Юрковский Алексей Михайлович, д.м.н., доцент, заведующий кафедрой лучевой диагностики, лучевой терапии с курсом ФПКиП

Гомель

Аlexei М. Yurkovskiy, Doctor of Medical Sciences, Head of the Department of Radiation Diagnostics, Radiation Therapy with the course of the Faculty of Professional Development and Retraining

Gomel

yurkovsky@mail.ruhttps://orcid.org/0000-0002-8516-0884СтародубцеваМ. Н.StarodubtsevaM. N.

Стародубцева Мария Николаевна, д.б.н., доцент, профессор кафедры медицинской и биологической физики; главный научный сотрудник лаборатории устойчивости биологических систем

Гомель

Maria N. Starodubtseva, Doctor of Biological Sciences, Associate Professor, Professor at the Department of Medical and Biological Physics; Chief Researcher at the Laboratory of Stability of Biological Systems

Gomel

Институт радиобиологии Национальной академии наук БеларусиInstitute of Radiobiology of the National Academy of Sciences of BelarusГомельский государственный медицинский университетGomel State Medical UniversityГомельский государственный медицинский университет; Институт радиобиологии Национальной академии наук БеларусиGomel State Medical University; Institute of Radiobiology of the National Academy of Sciences of Belarus2023020120242047–17Copyright © Матвеенкова Т.Д., Назаренко И.В., Юрковский А.М., Стародубцева М.Н., 20242024Матвеенкова Т.Д., Назаренко И.В., Юрковский А.М., Стародубцева М.Н.Matveyenkava T.D., Nazarenko I.V., Yurkovskiy А.М., Starodubtseva M.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/2637

Настоящий обзор посвящен анализу литературы, содержащей экспериментальные и клинические данные о радиационно-индуцированных изменениях соединительной ткани и ее клеточного компонента, для создания общей картины ведущих механизмов развития радиационного фиброза.В обзоре были проанализированы публикации за временной промежуток 1995–2022 гг., представленные в трех академических базах данных: Scopus, PubMed и Web of Science. В процессе поиска использовались различные комбинации логических операторов (or, and, not) для объединения ключевых слов поиска (ионизирующее излучение, соединительная ткань, фибробласты), чтобы найти соответствующие исследования в академических базах данных.Развитие радиационного фиброза определяется радиационно-индуцированными изменениями свойств и функций фибробластов. В статье обсуждены основные биологические эффекты облучения фибробластических клеток рентгеновским, гаммаи альфа-излучениями, представлены механизмы радиационно-индуцированной дифференцировки в системе фибробласт/миофибробласт, а также отмечена роль в данном процессе микроокружения соединительной ткани и ассоциированного с митохондриями окислительного стресса. Представленные в обзоре основные экспериментально установленные эффекты и общая схема механизмов нелетального действия ионизирующего излучения на фибробласты способствуют лучшему пониманию механизмов развития радиационно-индуцированного фиброза. 

This review is devoted to the analysis of the literature containing experimental and clinical data on radiation-induced changes in connective tissue and its cellular component to create an overall picture of the leading mechanisms of radiation fibrosis development.The review analyzed publications for the period 1995-2022, presented in three academic databases: Scopus, PubMed and Web of Science. In the search process, various combinations of logical operators (or, and, not) were used to combine search keywords (ionizing radiation, connective tissue, fibroblasts) to find relevant studies in academic databases. The development of radiation fibrosis is determined by radiation-induced changes in the properties and functions of fibroblasts. The article discusses the main biological effects of irradiation of fibroblastic cells with X-ray, gamma and alpha radiation, presents the mechanisms of radiation-induced differentiation in the fibroblast/myofibroblast system, and also notes the role of connective tissue microenvironment and oxidative stress associated with mitochondria in this process. The main experimentally established effects presented in the review and the general scheme of the mechanisms of non-lethal action of ionizing radiation on fibroblasts contribute to a better understanding of the mechanisms of radiation-induced fibrosis development

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The authors declare that there are no conflicts of interest present.