zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2023-20-3-01zdor-2582Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESСовременные возможности коррекции железодефицитной анемии тяжелой степени во время беременностиModern possibilities for correcting of severe iron deficiency anemia during pregnancyhttps://orcid.org/0000-0003-0562-3357ЭйнышЕ. А.EinyshE. A.

Эйныш Елена Александровна, к.м.н., доцент, доцент кафедры акушерства и гинекологии с курсом ФПКиП

г. Гомель

Elena A. Einysh, Candidate of Medical Sciences, Associate Professor of the Department of Obstetrics and Gynecology with the course of Advanced Training and Retraining

Gomel

miv65@mail.ruhttps://orcid.org/0000-0002-0715-7356ВакульчикИ. О.VaculchikI. O.

Вакульчик Игорь Олегович, заместитель главного врача по родовспоможению

г. Гомель

Igor O. Vakulchik, Deputy Head Physician for Obstetrics

Gomel

vaculchirigor@mail.ruhttps://orcid.org/0000-0002-6292-6533ВакульчикЛ. И.VaculchikL. I.

Вакульчик Людмила Ивановна, врач-ординатор 1-го обсервационного отделения

г. Гомель

Ludmila I. Vaculchik, Physician of the 1st Observational Obstetrical Department

Gomel

vaculcik552@gmail.comhttps://orcid.org/0000-0002-2408-8655ЛукашенкоЕ. Г.LukashenkoE. G.

Лукашенко Елена Григорьевна, заведующий родовым отделением

г. Гомель

Elena G. Lukashenko, Head of the Maternity Department

Gomel

helenluk197@mail.ruhttps://orcid.org/0000-0001-6487-2738КравцоваН. В.KrautsovaN. V.

Кравцова Наталья Валерьевна, заведующий отделением патологии беременности

г. Гомель

Natalyia V. Krautsova, Head of the Department of Pregnancy Pathology

Gomel

dariyakravts@gmail.comhttps://orcid.org/0000-0001-7176-6941КиселеваТ. А.KiselyovaT. A.

Киселева Татьяна Александровна, заведующий 2-м обсервационным отделением

г. Гомель

Tatyana A. Kiselyova, Head of the 2nd Observational Obstetrical Department

Gomel

kista2@ya.ruГомельский государственный медицинский университетGomel State Medical UniversityГомельская городская клиническая больница № 3Gomel City Clinical Hospital No. 3202325092023203712Copyright © Эйныш Е.А., Вакульчик И.О., Вакульчик Л.И., Лукашенко Е.Г., Кравцова Н.В., Киселева Т.А., 20232023Эйныш Е.А., Вакульчик И.О., Вакульчик Л.И., Лукашенко Е.Г., Кравцова Н.В., Киселева Т.А.Einysh E.A., Vaculchik I.O., Vaculchik L.I., Lukashenko E.G., Krautsova N.V., Kiselyova T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/2582

Проведен аналитический обзор данных литературы по современным методам лечения беременных пациенток с железодефицитной анемией (ЖДА) тяжелой степени. Приведены собственные данные о результатах лечения ЖДА тяжелой степени у двух беременных пациенток, находившихся в отделении патологии беременности ГУЗ «Гомельская городская клиническая больница № 3» (ГУЗ «ГГКБ № 3») в октябре – ноябре 2022 г. Подтверждены данные литературы о высокой эффективности лечения беременных пациенток с ЖДА тяжелой степени внутривенной инфузией железа карбоксимальтозата в дозе 1000 мг. Отсутствие непосредственных неблагоприятных побочных эффектов и осложнений беременности позволяет считать обоснованным применение данного препарата во 2-м и 3-м триместрах в комплексном лечении ЖДА.

An analytical review of literature data on modern methods of treatment of pregnant patients with severe iron deficiency anemia (IDA) was carried out. The authors present their own data on the results of treatment of severe IDA in two pregnant patients who were in the Department of Pregnancy Pathology of the Gomel City Clinical Hospital №3 in October – November 2022. Literature data on the high effectiveness of treatment of pregnant patients with severe IDA by intravenous infusion of iron carboxymaltosate in a dose of 1000 mg . The absence of immediate adverse side effects and complications of pregnancy makes it reasonable to use this drug in the 2nd and 3rd trimesters in the complex treatment of IDA.

беременностьжелезодефицитная анемияпарентеральные препараты железакарбоксимальтозат железаосложнения беременностиpregnancyiron deficiency anemiaparenteral iron preparationsiron carboxymaltosatepregnancy complicationsReferencesStanley AY, Wallace JB, Hernandez AM, Spell JL. Anemia in Pregnancy: Screening and Clinical Management Strategies. MCN Am J Matern Child Nurs. 2022 Jan-Feb 01;47(1):25-32. DOI: https://doi.org/10.1097/NMC.0000000000000787Stanley AY, Wallace JB, Hernandez AM, Spell JL. Anemia in Pregnancy: Screening and Clinical Management Strategies. MCN Am J Matern Child Nurs. 2022 Jan-Feb 01;47(1):25-32. DOI: https://doi.org/10.1097/NMC.0000000000000787Means RT. Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters. Nutrients. 2020 Feb 11;12(2):447. DOI: https://doi.org/10.3390/nu12020447Means RT. Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters. Nutrients. 2020 Feb 11;12(2):447. DOI: https://doi.org/10.3390/nu12020447James AH. Iron Deficiency Anemia in Pregnancy. Obstet Gynecol. 2021 Oct 1;138(4):663-674. DOI: https://doi.org/10.1097/AOG.0000000000004559James AH. Iron Deficiency Anemia in Pregnancy. Obstet Gynecol. 2021 Oct 1;138(4):663-674. DOI: https://doi.org/10.1097/AOG.0000000000004559Igbinosa I, Berube C, Lyell DJ. Iron deficiency anemia in pregnancy. Curr Opin Obstet Gynecol. 2022 Apr 1;34(2):69-76. DOI: https://doi.org/10.1097/GCO.0000000000000772Igbinosa I, Berube C, Lyell DJ. Iron deficiency anemia in pregnancy. Curr Opin Obstet Gynecol. 2022 Apr 1;34(2):69-76. DOI: https://doi.org/10.1097/GCO.0000000000000772Мозговая Е.В., Юсенко О.Н., Аржанова О.Н., Ковалева Т.Г. Опыт внутривенной ферротерапии препаратом железа (III) гидроксида олигоизомальтозата при лечении анемии у беременных. Лечащий врач. 2018;(12):11-19.Mozgovaya EV, Yusenko ON, Arzhanova ON, Kovaleva TG. Experience of intravenous ferrotherapy with iron (III) hydroxide polyisomaltosate oligoizomaltozat in the treatment of animia in pregnant women. Lechashij vrach. 2018;(12):11-19. (In Russ.).Govindappagari S, Burwick RM. Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta-Analysis. Am J Perinatol. 2019 Mar;36(4):366-376. DOI: https://doi.org/10.1055/s-0038-1668555Govindappagari S, Burwick RM. Treatment of Iron Deficiency Anemia in Pregnancy with Intravenous versus Oral Iron: Systematic Review and Meta-Analysis. Am J Perinatol. 2019 Mar;36(4):366-376. DOI: https://doi.org/10.1055/s-0038-1668555Lewkowitz AK, Stout MJ, Cooke E, Deoni SC, D’Sa V, Rouse DJ, Carter EB, Tuuli MG. Intravenous versus Oral Iron for Iron-Deficiency Anemia in Pregnancy (IVIDA): A Randomized Controlled Trial. Am J Perinatol. 2022 Jun;39(8):808-815. DOI: https://doi.org/10.1055/s-0041-1740003Lewkowitz AK, Stout MJ, Cooke E, Deoni SC, D’Sa V, Rouse DJ, Carter EB, Tuuli MG. Intravenous versus Oral Iron for Iron-Deficiency Anemia in Pregnancy (IVIDA): A Randomized Controlled Trial. Am J Perinatol. 2022 Jun;39(8):808-815. DOI: https://doi.org/10.1055/s-0041-1740003Wesström J. Safety of intravenous iron isomaltoside for iron deficiency and iron deficiency anemia in pregnancy. Arch Gynecol Obstet. 2020 May;301(5):1127-1131. DOI: https://doi.org/10.1007/s00404-020-05509-2Wesström J. Safety of intravenous iron isomaltoside for iron deficiency and iron deficiency anemia in pregnancy. Arch Gynecol Obstet. 2020 May;301(5):1127-1131. DOI: https://doi.org/10.1007/s00404-020-05509-2Rogozińska E, Daru J, Nicolaides M, Amezcua-Prieto C, Robinson S, Wang R, Godolphin PJ, Saborido CM, Zamora J, Khan KS, Thangaratinam S. Iron preparations for women of reproductive age with iron deficiency anaemia in pregnancy (FRIDA): a systematic review and network meta-analysis. Lancet Haematol. 2021 Jul;8(7): e503-e512. DOI: https://doi.org/10.1016/S2352-3026(21)00137-XRogozińska E, Daru J, Nicolaides M, Amezcua-Prieto C, Robinson S, Wang R, Godolphin PJ, Saborido CM, Zamora J, Khan KS, Thangaratinam S. Iron preparations for women of reproductive age with iron deficiency anaemia in pregnancy (FRIDA): a systematic review and network meta-analysis. Lancet Haematol. 2021 Jul;8(7): e503-e512. DOI: https://doi.org/10.1016/S2352-3026(21)00137-XFroessler B, Gajic T, Dekker G, Hodyl NA. Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy. Arch Gynecol Obstet. 2018 Jul;298(1):75-82. DOI: https://doi.org/10.1007/s00404-018-4782-9Froessler B, Gajic T, Dekker G, Hodyl NA. Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy. Arch Gynecol Obstet. 2018 Jul;298(1):75-82. DOI: https://doi.org/10.1007/s00404-018-4782-9Jose A, Mahey R, Sharma JB, Bhatla N, Saxena R, Kalaivani M, Kriplani A. Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy- randomised controlled trial. BMC Pregnancy Childbirth. 2019 Feb 4;19(1):54. DOI: https://doi.org/10.1186/s12884-019-2200-3Jose A, Mahey R, Sharma JB, Bhatla N, Saxena R, Kalaivani M, Kriplani A. Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy- randomised controlled trial. BMC Pregnancy Childbirth. 2019 Feb 4;19(1):54. DOI: https://doi.org/10.1186/s12884-019-2200-3Shin HW, Go DY, Lee SW, Choi YJ, Ko EJ, You HS, Jang YK. Comparative efficacy and safety of intravenous ferric carboxymaltose and iron sucrose for iron deficiency anemia in obstetric and gynecologic patients: A systematic review and metaanalysis. Medicine (Baltimore). 2021 May 21;100(20):e24571. DOI: https://doi.org/10.1097/MD.0000000000024571Shin HW, Go DY, Lee SW, Choi YJ, Ko EJ, You HS, Jang YK. Comparative efficacy and safety of intravenous ferric carboxymaltose and iron sucrose for iron deficiency anemia in obstetric and gynecologic patients: A systematic review and metaanalysis. Medicine (Baltimore). 2021 May 21;100(20):e24571. DOI: https://doi.org/10.1097/MD.0000000000024571Scott LJ. Ferric Carboxymaltose: A Review in Iron Deficiency. Drugs. 2018 Mar;78(4):479-493. DOI: https://doi.org/10.1007/s40265-018-0885-7Scott LJ. Ferric Carboxymaltose: A Review in Iron Deficiency. Drugs. 2018 Mar;78(4):479-493. DOI: https://doi.org/10.1007/s40265-018-0885-7Trivedi P, Chitra S, Natarajan S, Amin V, Sud S, Vyas P, et al. Ferric Carboxymaltose in the Management of Iron Deficiency Anemia in Pregnancy: A Subgroup Analysis of a Multicenter Real- World Study Involving 1191 Pregnant Women. Obstet Gynecol Int. 2022 Nov 28; 2022:5759740. DOI: https://doi.org/10.1155/2022/5759740Trivedi P, Chitra S, Natarajan S, Amin V, Sud S, Vyas P, et al. Ferric Carboxymaltose in the Management of Iron Deficiency Anemia in Pregnancy: A Subgroup Analysis of a Multicenter Real- World Study Involving 1191 Pregnant Women. Obstet Gynecol Int. 2022 Nov 28; 2022:5759740. DOI: https://doi.org/10.1155/2022/5759740Qassim A, Grivell RM, Henry A, Kidson-Gerber G, Shand A, Grzeskowiak LE. Intravenous or oral iron for treating iron deficiency anaemia during pregnancy: systematic review and meta-analysis. Med J Aust. 2019 Oct;211(8):367-373. DOI: https://doi.org/10.5694/mja2.50308Qassim A, Grivell RM, Henry A, Kidson-Gerber G, Shand A, Grzeskowiak LE. Intravenous or oral iron for treating iron deficiency anaemia during pregnancy: systematic review and meta-analysis. Med J Aust. 2019 Oct;211(8):367-373. DOI: https://doi.org/10.5694/mja2.50308Gupte SA, Venkataraman G, Shah AS, Mudholkar AS, Jangam SM. Clinical effects and safety of ferric carboxymaltose in pregnancy: An Indian real-life experience. J Obstet Gynaecol Res. 2021 Oct;47(10):3464-3470. DOI: https://doi.org/10.1111/jog.14956Gupte SA, Venkataraman G, Shah AS, Mudholkar AS, Jangam SM. Clinical effects and safety of ferric carboxymaltose in pregnancy: An Indian real-life experience. J Obstet Gynaecol Res. 2021 Oct;47(10):3464-3470. DOI: https://doi.org/10.1111/jog.14956Abdelazim IA, Nusair B, Svetlana S, Zhurabekova G. Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy. Arch Gynecol Obstet. 2018 Dec;298(6):1231-1232. DOI: https://doi.org/10.1007/s00404-018-4943-xAbdelazim IA, Nusair B, Svetlana S, Zhurabekova G. Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy. Arch Gynecol Obstet. 2018 Dec;298(6):1231-1232. DOI: https://doi.org/10.1007/s00404-018-4943-xPavord S, Daru J, Prasannan N, Robinson S, Stanworth S, Girling J; BSH Committee. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 2020 Mar;188(6):819-830. DOI: https://doi.org/10.1111/bjh.16221Pavord S, Daru J, Prasannan N, Robinson S, Stanworth S, Girling J; BSH Committee. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol. 2020 Mar;188(6):819-830. DOI: https://doi.org/10.1111/bjh.16221Auerbach M. Commentary: Iron deficiency of pregnancy - a new approach involving intravenous iron. Reprod Health. 2018 Jun 22;15(Suppl 1):96. DOI: https://doi.org/10.1186/s12978-018-0536-1Auerbach M. Commentary: Iron deficiency of pregnancy - a new approach involving intravenous iron. Reprod Health. 2018 Jun 22;15(Suppl 1):96. DOI: https://doi.org/10.1186/s12978-018-0536-1Auerbach M, Henry D, DeLoughery TG. Intravenous ferric derisomaltose for the treatment of iron deficiency anemia. Am J Hematol. 2021 Jun 1;96(6):727-734. DOI: https://doi.org/10.1002/ajh.26124Auerbach M, Henry D, DeLoughery TG. Intravenous ferric derisomaltose for the treatment of iron deficiency anemia. Am J Hematol. 2021 Jun 1;96(6):727-734. DOI: https://doi.org/10.1002/ajh.26124

The authors declare that there are no conflicts of interest present.