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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2023-20-2-19</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-2561</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ КЛИНИЧЕСКОЙ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Дифференциальная диагностика акромегалии и пахидермопериостоза</article-title><trans-title-group xml:lang="en"><trans-title>Differential diagnosis of acromegaly and pachydermoperiostosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1746-8710</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Холупко</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kholupko</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Холупко Наталья Владимировна, врач-эндокринолог эндокринологического отделения</p><p>Гомель</p></bio><bio xml:lang="en"><p>Natalia V. Kholupko, Endocrinologist at the Department of Endocrinology</p><p>Gomel</p></bio><email xlink:type="simple">n_ata@tut.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6197-4077</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ващенко</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Vashchenko</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ващенко Елена Николаевна, врач-эндокринолог  эндокринологического отделения</p><p>Гомель</p></bio><bio xml:lang="en"><p>Elena N. Vashchenko, Endocrinologist at the Departmentof Endocrinology</p><p>Gomel</p></bio><email xlink:type="simple">elenavashenko@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1251-1962</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Махлина</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Makhlina</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Махлина Елена Семеновна, к.м.н., доцент, врач-эндокринолог эндокринологического отделения</p><p>Гомель</p></bio><bio xml:lang="en"><p>Alena S. Makhlina, Candidate of Medical Sciences, Associate Professor, Endocrinologist at the Department  of Endocrinology</p><p>Gomel</p></bio><email xlink:type="simple">mahlina.elena@yandex.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7033-719X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Навменова</surname><given-names>Я. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumenava</surname><given-names>Ya. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Навменова Яна Леонидовна, к.м.н., доцент, врач-эндокринолог (заведующий) эндокринологического отделения</p><p>Гомель</p></bio><bio xml:lang="en"><p>Yana L. Naumenava, Candidate of Medical Sciences, Associate Professor, Head of the Department of  Endocrinology</p><p>Gomel</p></bio><email xlink:type="simple">yano4ka.n@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9965-8424</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рожко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Razhko</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рожко Александр Валентинович д.м.н., профессор,  директор</p><p>Гомель</p></bio><bio xml:lang="en"><p>Alexandr V. Razhko, Doctor of Medical Sciences,  Associate Professor, Director</p><p>Gomel</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Республиканский научно-практический центр радиационной медицины и экологии человека</institution></aff><aff xml:lang="en"><institution>Republican Research Center for Radiation Medicine and Human Ecology</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>10</day><month>07</month><year>2023</year></pub-date><volume>20</volume><issue>2</issue><fpage>146</fpage><lpage>151</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Холупко Н.В., Ващенко Е.Н., Махлина Е.С., Навменова Я.Л., Рожко А.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Холупко Н.В., Ващенко Е.Н., Махлина Е.С., Навменова Я.Л., Рожко А.В.</copyright-holder><copyright-holder xml:lang="en">Kholupko N.V., Vashchenko E.N., Makhlina A.S., Naumenava Y.L., Razhko A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/2561">https://journal.gsmu.by/jour/article/view/2561</self-uri><abstract><p>Акромегалия — нейроэндокринное заболевание с многообразными клиническими проявлениями, развивающимися в течение длительного времени. В процессе обследования пациента может возникнуть необходимость проведения дифференциальной диагностики акромегалии с различными синдромами и состояниями, в том числе с таким редким заболеванием, как пахидермопериостоз. Особенности клинической картины и диагностики представлены в описании клинического случая из нашей практики.</p></abstract><trans-abstract xml:lang="en"><p>Acromegaly is a neuroendocrine disease with diverse clinical manifestations that develop over a long period. In the process of examining a patient, it may be necessary to conduct a differential diagnosis of acromegaly with various syndromes and conditions, including such a rare disease as pachydermoperiostosis. Features of the clinical presentation and diagnosis are given in the description of a clinical case from our practice.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>акромегалия</kwd><kwd>пахидермопериостоз</kwd><kwd>дифференциальная диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acromegaly</kwd><kwd>pachydermoperiostosis</kwd><kwd>differential diagnosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Молитвословова Н.Н. Акромегалия: современные достижения в диагностике и лечении. Проблемы эндокринологии. 2011;57(1):46-59.</mixed-citation><mixed-citation xml:lang="en">Molitvoslovova N.N. Acromegaly: recent progress in diagnostics and treatment. Problemy Endokrinologii. 2011;57(1):46-59. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Вакс В.В. 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