zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2023-20-2-03zdor-2545Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEОпределение уровня лептина и растворимого рецептора лептина у пациенток с гиперпластическими процессами эндометрияMeasurement of leptin and soluble leptin receptor levels in patients with endometrial hyperplastic processeshttps://orcid.org/0000-0002-8465-9368ЛызиковаЮ. А.LyzikovaYu. A.

Лызикова Юлия Анатольевна, д.м.н., доцент,  профессор кафедры акушерства и гинекологии с  курсом ФПКиП

Гомель

Yuliya A. Lyzikova, Doctor of Medical Sciences,  Associate Professor, Professor of the Department of  Obstetrics and Gynecology with the course of FPDR

Gomel

lyzikovayulia@yandex.byhttps://orcid.org/0000-0002-2606-7006СмирноваМ. В.SmirnovaM. V.

Смирнова Марина Владимировна, врач ультразвуковой диагностики

Гомель

Maryna V. Smirnova, Ultrasound Diagnostics Doctor

Gomel

marinasmirnova6793@mail.ruГомельский государственный медицинский университетGomel State Medical UniversityГомельская городская клиническая больница № 2Gomel City Clinical Hospital № 22023100720232022226Copyright © Лызикова Ю.А., Смирнова М.В., 20232023Лызикова Ю.А., Смирнова М.В.Lyzikova Y.A., Smirnova M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/2545

Цель исследования. Оценить уровни лептина и растворимого рецептора лептина у пациентов с гиперпластическими процессами эндометрия.Материалы и методы. В исследование включено 90 пациентов, из них 70 с гиперпластическими процессами эндометрия составили основную группу, 20 с морфологически нормальным эндометрием включены в группу сравнения. Методом иммуноферментного анализа в сыворотке крови определена концентрация лептина и растворимого рецептора лептина, изучены клинико-анамнестические характеристики заболевания.Результаты. При сравнении уровня лептина в сыворотке крови не получено значимых различий между группами: в основной группе уровень гормона составил 6,01 (3,64; 7,50) нг/мл, в группе сравнения — 6,44 (3,55; 10,11) нг/мл (z = 0,61, p = 0,54). Уровень растворимого рецептора лептина у пациенток основной группы был значимо ниже и составил 8531 (5697; 15895) пг/мл, в группе сравнения — 16181 (10696; 20251) пг/мл (z = 2,614, p = 0,008).Заключение. Для пациентов с гиперпластическими процессами эндометрия характерно снижение уровня растворимого рецептора лептина, в то время как уровень лептина не имеет значимых различий по сравнению с аналогичным показателем у пациенток без патологии эндометрия. Выявленное состояние обуславливает дефект передачи сигнала от лептинового рецептора и снижение транспорта гормона, приводящее к нарушению биологического действия лептина. Установленный уровень растворимого рецептора лептина < 14769 пг/мл, в комплексе с ультразвуковым методом исследования, позволит повысить эффективность диагностических мероприятий по выявлению гиперпластических процессов эндометрия.

Objective. To measure leptin and soluble leptin receptor levels in patients with endometrial hyperplastic processes.Materials and methods. 90 patients were included in the study, 70 with hyperplastic endometrial processes made up the main group, 20 with morphologically normal endometrium were included in the comparison group. The concentration of leptin and the soluble leptin receptor in the blood serum was measured by the method of enzyme immunoassay, the clinical and anamnestic characteristics of the disease were studied Results. There were no significant differences between the groups when comparing serum leptin levels: in the study group, the hormone level was 6,01 (3,64;7,50) ng/ml, in the comparison group — 6,44 (3,55;10,11) ng/ml (z = 0,61, p = 0,54). The level of soluble leptin receptor was significantly lower in patients in the main group and was 8531 (5697; 15895) ng/ml, and 16181 (10696; 20251) ng/ml in the comparison group (z = 2.614, p = 0.008).Conclusion. Patients with endometrial hyperplastic processes are characterized by a decreased level of the soluble leptin receptor, whereas a leptin level has no significant differences compared to those in patients without endometrial pathology. The identified condition causes a defect in the signal transmission from the leptin receptor and a decrease in the hormone transport, leading to a disruption of the biological action of leptin. The established level of soluble leptin receptor < 14769 pg/ml, in combination with ultrasound examination, will increase the efficiency of diagnostic measures to detect endometrial hyperplastic processes.

гиперпластические процессы эндометриялептинрастворимый рецептор лептинаendometrial hyperplastic processesleptinsoluble leptin receptorНаучная работа выполнена за счет средств инновационного фонда Гомельского областного исполнительного комитета в рамках проекта «Разработать и внедрить метод персонализированного лечения гиперпластических процессов эндометрия женщин», № госрегистрации 20201765 от 05.11.2020 г.The study was sponsored by the Innovation Fund of the Gomel Regional Executive Committee within the framework of the project “To develop and implement a method of personalized treatment of endometrial hyperplastic processes in women”, state registration number 20201765 of 05.11.2020.ReferencesEl-Hamed AT, Mahmoud SA, Soliman AA, El-Yasergy DF. Immunohistochemical expression of “HE4” in endometrial hyperplasia versus endometrial endometrioid carcinoma. Open Access Macedonian Journal of Medical Sciences. 2021;9:669-675. 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The authors declare that there are no conflicts of interest present.