zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2023-20-1-03zdor-2490Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEЦитокиновый и гормональный статус у женщин репродуктивного возраста с туберкулезом легкихCytokine and hormone status of women of reproductive age with pulmonary tuberculosishttps://orcid.org/0000-0001-9965-7755ГопонякоС. В.GoponiakoS. V.

Гопоняко Светлана Владимировна, старший преподаватель кафедры фтизиопульмонологии с курсом ФПКиП

Гомель

Svetlana V. Goponiako, Senior Lecturer, Phthysiopulmonology department with course of the Faculty of Professional Development and Retraining

Gomel 

indigomind@mail.ruГомельский государственный медицинский университетGomel State Medical University2023280320232012631Copyright © Гопоняко С.В., 20232023Гопоняко С.В.Goponiako S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/2490Цель исследования

Цель исследования. Изучить уровень цитокинов (γ-интерферона, фактора некроза опухоли α (ФНО-α)) и гормонов (кортизола, пролактина, эстрадиола, прогестерона, тестостерона) в сыворотке крови у женщин репродуктивного возраста с туберкулезом (ТБ) легких.

Материалы и методы

Материалы и методы. Исследован уровень γ-интерферона, фактора некроза опухоли α, кортизола, пролактина, эстрадиола, прогестерона, тестостерона в сыворотке крови у женщин 18–45 лет с впервые выявленным ТБ легких (n = 47) в сравнении с аналогичными показателями у женщин, не страдающих ТБ и не болевших ТБ ранее (n = 35).

Результаты

Результаты. Женщины, страдающие ТБ легких, имели более высокие уровни кортизола (точка отсечения — 196,1 нмоль/л, AUC — 0,75, Se — 85,1 %, Sp — 70,6 %) и пролактина (точка отсечения — 486,1 мМЕ/л, AUC — 0,69, Se — 59,6 %, Sp — 73,5 %) и более низкий уровень прогестерона (точка отсечения — 3,9 нмоль/л, AUC — 0,71, Se — 73,9 %, Sp — 64,7 %) в сыворотке крови, чем женщины без ТБ. Исследование уровня γ-интерферона и ФНО-α показало меньшую диагностическую значимость параметров, отмечено некоторое повышение уровня обоих цитокинов у женщин с ТБ легких.

Заключение

Заключение. Изменения цитокиново-гормонального статуса у женщин с ТБ могут как отражать механизмы противоинфекционной защиты, так и быть следствием развития заболевания.

Objective

Objective. To study the levels of cytokines (γ-interferon, tumor necrosis factor α (TNF-α)) and hormones (cortisol, prolactin, estradiol, progesterone, testosterone) in blood serum of women of reproductive age with pulmonary tuberculosis (TB).

Materials and methods

Materials and methods. We studied the serum levels of γ-interferon, tumor necrosis factor α, cortisol, prolactin, estradiol, progesterone, testosterone in women 18-45 years old with newly diagnosed pulmonary TB (n = 47) compared with the same indices in women without TB and with no previous TB (n = 35).

Results

Results. Women with pulmonary TB had higher levels of cortisol (cutoff point, 196.1 nmol/L, AUC 0.75, Se 85.1 %, Sp 70.6 %) and prolactin (cutoff point, 486, 1 mEU/L, AUC 0.69, Se 59.6%, Sp 73.5%) and lower serum progesterone levels (cutoff point 3.9 nmol/L, AUC 0.71, Se 73.9%, Sp 64.7%) than women without TB. The study of the levels of γ-interferon and TNF-α showed less diagnostic significance of the parameters, and there was a slight increase in the levels of both cytokines in women with pulmonary TB.

Conclusion

Conclusion. Changes in cytokine-hormone status in women with TB can both reflect mechanisms of anti-infective defense and be a consequence of the development of the disease.

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The authors declare that there are no conflicts of interest present.