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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2022-19-4-09</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-2410</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Показатель «риск вреда от употребления алкоголя» (шкала ASSIST) у пациентов с шизофренией и близкими к ней расстройствами</article-title><trans-title-group xml:lang="en"><trans-title>Indicator “Risk of harm from alcohol use” (ASSIST score ) in patients with schizophrenia and related disorders</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5352-9384</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хмара</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Hmara</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хмара Наталия Викторовна, старший преподавателькафедры неврологии и нейрохирургии с курсами медицинской реабилитации, психиатрии, ФПКиП</p><p>Гомель</p></bio><bio xml:lang="en"><p>Natalia V. Hmara, Senior Lecturer of the Departmentof Neurology and Neurosurgery with the courses of Medical Rehabilitation, Psychiatry and with course of the Faculty of Professional Development and Retraining </p><p>Gomel</p></bio><email xlink:type="simple">grintuch1@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4439-5046</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скугаревский</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Skugarevsky</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Скугаревский Олег Алексеевич, д.м.н., профессор, заведующий кафедрой психиатрии и медицинской психологии</p><p>Минск</p></bio><bio xml:lang="en"><p>Oleg A. Skugarevsky, Doctor of Medical Sciences,Professor, Head of the Department of Psychiatry and Medical Psychology</p><p>Minsk </p></bio><email xlink:type="simple">sKugarevsky@tut.by</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Гомельский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Gomel State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Белорусский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Belarusian State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>04</day><month>01</month><year>2023</year></pub-date><volume>19</volume><issue>4</issue><fpage>66</fpage><lpage>72</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Хмара Н.В., Скугаревский О.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Хмара Н.В., Скугаревский О.А.</copyright-holder><copyright-holder xml:lang="en">Hmara N.V., Skugarevsky O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/2410">https://journal.gsmu.by/jour/article/view/2410</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Установить связь между показателем шкалы ASSIST (Humeniuk R. et al., 2008) «риск вреда от употребления алкоголя» (РВУА), нарушением социального функционирования и проявлением агрессии у пациентов с шизофренией и близкими к ней расстройствами.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В период с 2014 по 2020 г. на базе учреждения «Гомельская областная клиническая психиатрическая больница» было проведено сравнительное, одномоментное, обсервационное исследование с формированием выборки методом направленного отбора. В исследование включались пациенты, которые соответствовали диагностическим критериям шизофрении (F20) или острого психотического расстройства (F23) по МКБ-10. Применялись следующие методы оценки: 1) скрининг на употребление алкоголя, шкала ASSIST (Humeniuk R. et al., 2008), 2) определение уровня агрессии OASCL (Yudofsky S. C., 1986).</p></sec><sec><title>Результаты</title><p>Результаты. Вся обследуемая нами выборка — 123 человека — была разделена на 3 группы в зависимости от уровня РВУА. Первая группа «ASSIST 0» (n = 37) была контрольной, так как РВУА здесь был равен 0. Вторая группа «ASSIST до 10» (n = 42) была с минимальным РВУА (1–10 баллов по шкале ASSIST). Третья группа «ASSIST свыше 11» (n = 44) объединяла пациентов с умеренным и высоким РВУА. Исследование групп не показало различий между мужчинами и женщинами при употреблении алкоголя и проявлении агрессии внутри групп. Сопоставление трех групп и последующее их попарное сравнение позволило установить статистически значимые различия в группах по социальной дисфункции (снижение рабочего статуса: «ASSIST 0» — 81 %, «ASSIST свыше 11» — 73 %, «ASSIST до 10» — 45 %) и проявлению агрессии (OASCL, общий балл H = 62,4, p ≤ 0,001; физическая агрессия против других, H = 45,2, p ≤ 0,001).</p></sec><sec><title>Заключение</title><p>Заключение. У пациентов с шизофренией и близкими к ней расстройствами показатель «риск вреда от употребления алкоголя» (шкала ASSIST) косвенно свидетельствует о формировании психосоциальной дисфункции и указывает на дифференцированное влияние алкоголя в проявлении агрессии данной группы пациентов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective. To establish the relationship between the ASSIST score (Humeniuk R. et al. 2008) «risk of harm from alcohol use» (RHAU), impaired social functioning and manifestation of aggression in patients with schizophrenia and related disorders.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. From 2014 to 2020 a comparative, one-stage, observational study was conducted on the basis of the Gomel Regional Clinical Psychiatric Hospital with a sampling formation using directional selection method. Patients who met diagnostic criteria of schizophrenia (F20) or acute psychotic disorder (F23) according to ICD-10 were included in the study. The following assessment methods were used: 1) screening for alcohol use – ASSIST scale (Humeniuk R. et al. 2008), 2) determination of the level of aggression OASCL (Yudofsky S. C. 1986).</p></sec><sec><title>Results</title><p>Results. The entire sample of 123 people examined by us was divided into 3 groups depending on the level of RHAU. The first group «ASSIST 0» (n=37) was accepted as a control group, since RHAU was equal to 0. The second group is «ASSIST up to 10» (n=42), with minimal RVUA (1-10 points on the ASSIST scale). The third group «ASSIST over 11» (n=44) combines moderate and high RHAU. The group study did not show any differences between men and women in alcohol consumption and aggression within the groups. Comparison of 3 groups, and their subsequent pairwise comparison, made it possible to establish statistically significant differences in social dysfunction groups (decrease in the working status of «ASSIST 0» – 81%, «ASSIST over 11» – 73%, «ASSIST up to 10» – 45%) and of aggression (OASCL total score H 62.4=p≤0.001: physical aggression vs. others H=45.2 p≤0.001).</p></sec><sec><title>Conclusion</title><p>Conclusion. In patients with schizophrenia and disorders close to it, the «risk of harm from alcohol use» indicator (ASSIST scale) indirectly indicates the formation of psychosocial dysfunction and indicates a differentiated effect of alcohol in the display of aggression in this group of patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>шизофрения</kwd><kwd>«риск вреда от употребления алкоголя»</kwd><kwd>психосоциальная дисфункция</kwd><kwd>агрессия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>schizophrenia</kwd><kwd>«risk of harm from alcohol use» (RHAU)</kwd><kwd>psychosocial dysfunction</kwd><kwd>aggression</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Volavka J, Citrome L Pathways to aggression in schizophrenia affect results of treatment. Schizophrenia bulletin. 2011;37(5):921-929. 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