zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2022-19-4-07zdor-2406Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEКлиническая значимость полиморфизма C(–344)T гена альдостеронсинтазы (CYP11B2) в прогнозе кардиоренального синдрома при сахарном диабетеClinical significance of the T(-344)C polymorphism of the aldosterone synthase gene (CYP11B2) in the prognosis of cardiorenal syndrome in diabetes mellitushttps://orcid.org/0000-0002-6956-9014ВасильковаО. Н.VasilkovaV. N.

Василькова Ольга Николаевна, к.м.н., доцент кафедры внутренних болезней № 1 с курсом эндокринологии

Гомель

Volha N. Vasilkova, Candidate of Medical Sciences,Associate Professor of the Department of Internal Diseases №1 with a course of Endocrinology 

Gomel

olga.n.vasilkova@gmail.comhttps://orcid.org/0000-0001-8529-3890ПчелинИ. Ю.PchelinI. Yu.

Пчелин Иван Юрьевич, к.м.н., доцент, выполняющий лечебную работу кафедры факультетской терапии

Санкт-Петербург

Ivan Yu. Pchelin, Candidate of Medical Sciences, Associate Professor performing clinical work at the Department of Faculty Therapy

St. Petersburg

ewan2008@bk.ruhttps://orcid.org/0000-0001-8884-1637БоровецЯ. А.BorovetsYa. A.

Боровец Яна Анатольевна, ассистент кафедры внутренних болезней № 1 с курсом эндокринологии

Гомель

Yana A. Borovets, Assistant of the Department of Internal Diseases №1 with a course of Endocrinology

Gomel

yana.gh.l.br@gmail.comhttps://orcid.org/0000-0002-9740-9915ВасюхинаИ. А.VasukhinaI. A.

Васюхина Ирина Александровна, врач-эндокринолог

Гомель

Irina A. Vasukhina, Endocrinologist 

Gomel 

vasyhina20081978@gmail.comhttps://orcid.org/0000-0002-5040-3460МохортТ. В.MokhortT. V.

Мохорт Татьяна Вячеславовна, д.м.н., профессор,заведующий кафедрой эндокринологии

Минск

Tatsiana V. Mokhort, Doctor of Medical Sciences,Professor, Head of the Department of Endocrinology

Minsk 

tatsianamokhort@gmail.comГомельский государственный медицинский университетGomel State Medical UniversityСанкт-Петербургский государственный университетSt. Petersburg State UniversityРеспубликанский научно-практический центр радиационной медицины и экологии человекаRepublican Research Center for Radiation Medicine and Human EcologyБелорусский государственный медицинский университетBelarusian State Medical University2022030120231944855Copyright © Василькова О.Н., Пчелин И.Ю., Боровец Я.А., Васюхина И.А., Мохорт Т.В., 20232023Василькова О.Н., Пчелин И.Ю., Боровец Я.А., Васюхина И.А., Мохорт Т.В.Vasilkova V.N., Pchelin I.Y., Borovets Y.A., Vasukhina I.A., Mokhort T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/2406Цель исследования

Цель исследования. Оценить роль полиморфизма C(–344)T гена CYP11B2 в развитии кардиоренального синдрома (КРС) при сахарном диабете (СД).

Материалы и методы

Материалы и методы. Обследовано 270 пациентов с СД 1 и СД 2 типа в возрасте старше 25 лет. Всем пациентам проводился молекулярно-генетический анализ с использованием дезоксирибонуклеиновой кислоты (ДНК), выделенной из цельной венозной крови.

Результаты

Результаты. Генотип ТТ был ассоциирован с риском развития таких проявлений КРС, как гипертрофия левого желудочка (отношение шансов (ОШ) — 2,64; 95 % ДИ (0,93–4,19)), хроническая сердечная недостаточность (ОШ — 4,26; 95 % ДИ (2,26–8,06)), субклинический атеросклероз (ОШ — 4,04; 95 % ДИ (1,89–8,58)), хроническая болезнь почек (ХБП) (ОШ — 10,77; 95 % ДИ (3,56–32,61)), а генотип СТ (ОШ — 3,28; 95 % ДИ (1,02–10,59)) — с риском ХБП.

Заключение

Заключение. Между ренин-ангиотензин-альдостероновой системой (РААС), кардиоваскулярными осложнениями и снижением функциональной способности почек имеются патогенетические связи. Для глубокого понимания сложных патогенетических механизмов развития и прогрессирования кардиоваскулярной и почечной патологии необходимы дальнейшие исследования.

Objective

Objective. To evaluate the role of the T(-344)C polymorphism of CYP11B2 gene in the development of cardiorenal syndrome (CRS) in diabetes mellitus (DM).

Materials and methods

Materials and methods. 270 patients with type 1 and type 2 diabetes aged over 25 years were examined. All patients underwent molecular genetic analysis using deoxyribonucleic acid isolated from whole venous blood.

Results

Results. The TT genotype was associated with the risk of developing CRS manifestations such as left ventricular hypertrophy (odds ratio (OR) 2.64; 95% CI (0.93–4.19), chronic heart failure (OR 4.26; 95% CI (2.26 - 8.06), subclinical atherosclerosis (OR 4.04; 95% CI (1.89 - 8.58), chronic kidney disease (CKD) (OR 10.77; 95% CI (3.56 - 32.61), and the CT genotype (OR 3.28; 95% CI (1.02 – 10.59) with CKD risk..

Conclusion

Conclusion. There are pathogenetic associations between renin-angiotensin-aldosterone system, cardiovascular complications and a decrease of renal function. Further research is needed for a deep understanding of the complex pathogenetic mechanisms of the development and progression of cardiovascular and renal pathology.

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The authors declare that there are no conflicts of interest present.