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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2022-19-2-04</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-2274</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Сравнительный анализ течения инфекции COVID-19 в мае 2020 и 2021 гг. в больничной организации здравоохранения</article-title><trans-title-group xml:lang="en"><trans-title>Comparative analysis of the course of COVID-19 in May 2020 and May 2021 in a hospital healthcare organization</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6123-2919</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никифорова</surname><given-names>О. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikiforova</surname><given-names>O. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никифорова Ольга Леонидовна, ассистент кафедры поликлинической терапии и общеврачебной практики</p><p>г. Гомель</p></bio><bio xml:lang="en"><p>Olga L. Nikiforova, Assistant Lecturer at the Department of Polyclinic Therapy and General Practice</p><p>Gomel</p></bio><email xlink:type="simple">Nikiforova.O.L@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Гомельский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Gomel State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2022</year></pub-date><volume>19</volume><issue>2</issue><elocation-id>32–40</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Никифорова О.Л., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Никифорова О.Л.</copyright-holder><copyright-holder xml:lang="en">Nikiforova O.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/2274">https://journal.gsmu.by/jour/article/view/2274</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования. Провести аналитическую оценку динамики состояния у пациентов с инфекцией COVID-19 в условиях больничной организации здравоохранения с учетом коморбидных заболеваний в мае 2020 и 2021 гг. и определить прогностические показатели тяжелого течения инфекции COVID-19.Материалы и методы. Ретроспективно был проведен анализ 96 медицинских карт пациентов с инфекцией COVID-19, которые прошли курс лечения в государственном учреждении здравоохранения «Гомельская городская клиническая больница № 3» в мае 2020 г., и 130 медицинских карт пациентов с COVID-19 — в мае 2021 г.Результаты. Средний возраст для женщин, прошедших лечение в больничной организации здравоохранения по поводу пневмонии, ассоциированной с инфекцией COVID-19, в 2020 г. составил 58 лет, в 2021 г. — 64,5 года, для мужчин в 2020 г. — 58 лет, в 2021 г. — 60,5 года. Все пациенты проходили клиническое обследование согласно временным протоколам. Наиболее частым коморбидным фоном инфекции COVID-19 как в 2020 г., так и в 2021 г. явились ишемическая болезнь сердца (ИБС), артериальная гипертензия (АГ), неалкогольная жировая болезнь печени, сахарный диабет (СД), заболевания почек, ожирение. Полиморбидность в 2021 г. наблюдалась в 1,5 раза чаще по сравнению с 2020 г. (pFisher &lt; 0,001). Уровни С-реактивного белка (СРБ) и лактатдегидрогеназы (ЛДГ) статистически связаны со степенью тяжести пневмонии (rS = 0,33; p &lt; 0,001 и rS = 0,2; p = 0,03 соответственно). Уровень Neutrophil-to-Lymphocyte Ratio (NLR) у пациентов с легким течением пневмонии, ассоциированной с инфекцией COVID-19, в 2020 г. составил 1,58, в 2021 г. — 1,05, тогда как у пациентов с тяжелым течением в 2020 г. — 7,7, в 2021 г. — 10,63.</p></sec><sec><title>Заключение</title><p>Заключение. В качестве доступных методов прогноза в клинической практике в отношении течения инфекции COVID-19 у коморбидных пациентов служат СРБ, ЛДГ, NLR.</p></sec></abstract><trans-abstract xml:lang="en"><p>Objective. To perform an analytical assessment of the dynamics of COVID-19 patients` state in the conditions of a hospital healthcare organization taking into account their comorbid diseases in May 2020 and May 2021, and to determine the prognostic indicators for a severe course of COVID-19.Materials and methods. 96 medical records of COVID-19 patients who had undergone treatment at Gomel City Clinical Hospital No. 3 in May 2020 and 130 medical records of COVID-19 patients who had undergone treatment in May 2021 were retrospectively analyzed.Results. The average age of women treated for pneumonia associated with COVID-19 at the hospital healthcare organization in 2020 was 58 years, in 2021 – 64.5 years, of men in 2020 – 58 years, in 2021 – 60.5 years. All patients underwent clinical examination according to temporary protocols. The most common COVID-19 comorbid background diseases in both 2020 and 2021 were coronary artery disease (CAD), arterial hypertension (AH), non-alcoholic fatty liver disease, diabetes mellitus (DM), kidney disease, and obesity. Polymorbidity in 2021 was observed 1.5 times more often than in 2020 (pFisher&lt;0.001). C-reactive protein (CRP) and lactate dehydrogenase (LDH) levels are statistically associated with the severity of pneumonia (rS=0.33; p&lt;0.001 and rS=0.2; p=0.03, respectively). The neutrophillymphocyte ratio (NLR) level in patients with a mild course of pneumonia associated with COVID-19 in 2020 was 1.58, in 2021 – 1.05, while in patients with a severe course in 2020 – 7.7, in 2021 – 10.63.Conclusion. CRP, LDH and NLR serve as available methods for predicting the course of COVID-19 in comorbid patients in clinical practice.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инфекция COVID-19</kwd><kwd>коморбидные заболевания</kwd><kwd>стационар</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>comorbid diseases</kwd><kwd>hospital</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Попович ЮГ, Рахимова РЖ, Ахметжанова ДО. COVID-19 – новая инфекция XXI века. Наука и здравоохранение. 2020;4(22):15-23. [Электронный ресурс]. [дата обращения 2022 февраль 08]. Режим доступа: https://cyberleninka.ru/article/n/covid-19-novaya-infektsiya-xxi-veka</mixed-citation><mixed-citation xml:lang="en">Popovich YG, Rakhimova RJ, Akhmetzhanov D.O. COVID-19 is a new XXI century infection. Science and healthcare. 2020;4(22):15-23. [Electronic resource]. 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