zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2004-1-1-7zdor-2229Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEНАРУШЕНИЯ МЕТАБОЛИЗМА ГОМОЦИСТЕИНА, ЗАВИСИМОГО ОТ ФОЛИЕВОЙ КИСЛОТЫ КАК РЕАЛЬНЫЙ ФАКТОР РИСКА СИНДРОМА ДАУНА В ЯПОНИИABNORMAL FOLIC ACID HOMOCYSTEINE METABOLISM AS MATERNAL RISK FACTORS FOR DOWN SYNDROME IN JAPANTAKAMURANOBORUTAKAMURANOBORUKONDOHTATSUROKONDOHTATSUROOHGISYOHEIOHGISYOHEIARISAWAKOKICHIARISAWAKOKICHIMINEMARIKOMINEMARIKOYAMASHITASHUNICHIYAMASHITASHUNICHIAOYAGIKIYOSHIAOYAGIKIYOSHI20042005200401Проблемы здоровья и экологии4144Copyright © TAKAMURA N., KONDOH T., OHGI S., ARISAWA K., MINE M., YAMASHITA S., AOYAGI K., 20042004TAKAMURA N., KONDOH T., OHGI S., ARISAWA K., MINE M., YAMASHITA S., AOYAGI K.TAKAMURA N., KONDOH T., OHGI S., ARISAWA K., MINE M., YAMASHITA S., AOYAGI K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/2229

Обоснование: Япония считается «регионом с достатком фолатов», поскольку традиционная японская пища содержит достаточное количество фолиевой кислоты. Однако наметившаяся в последнее время «европеизация» образа питания молодых японских матерей способна повлиять на их потребление фолиевой кислоты. Это может вызвать увеличение частоты синдрома Дауна, поскольку доказано, что подобное питание связано с патологией метаболизма фолатов и гомоцистеина. Целью настоящего исследования является первоначальная оценка уровня фолиевой кислоты, гомоцистеина и других факторов, связанных с фолатовым метаболизмом у японских женщин, чья беременность была отягощена синдромом Дауна. Методы исследования: Были получены образцы крови от 31 женщины, чья беременность была отягощена синдромом Дауна (СД). Также были получены 60 образцов крови от женщин соответствующего возраста, чья беременность не закончилась выкидышем или патологией беременности. Было проведено измерение и сравнение гомоцистеина плазмы и сывороточной фолиевой кислоты, витамина B12 и В6 также была изучена частота полиморфизма MTHFR (C677T).

Department of Public Health, Department of Pediatrics, Department of Molecular Epidemiology, Biostatistics Section and Department of Molecular Medicine,Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan Background: Japan has been considered as «a folate sufficient area», since traditional Japanese food contains an adequate amount of folic acid. However, the recent westernized food style of young Japanese mothers may affect the intake of folic acid among them. This food style may contribute to the occurrence of Down syndrome, which has proved to be linked to abnormal folate and homocysteine metabolisms. Aim of the study: To preliminary evaluate the levels of folic acid, homocysteine and other relevant factors which are associated with folate metabolism, among Japanese women who had pregnancies affected by Down syndrome. Methods: Blood samples from 31 women who had pregnancies affected by Down syndrome (DS) were obtained. 60 age-matched control blood samples were also obtained from mothers who had not experienced miscarriages or abnormal pregnancies

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The authors declare that there are no conflicts of interest present.