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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2018-15-1-1</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-211</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>РОЛЬ НЕЙРОПЕПТИДОВ В ПАТОГЕНЕЗЕ ЛИГАМЕНТО- И ТЕНДИНОПАТИЙ И ИХ ВОЗМОЖНОЕ ВЛИЯНИЕ НА ХАРАКТЕР СОНОГРАФИЧЕСКОГО ПАТТЕРНА</article-title><trans-title-group xml:lang="en"><trans-title>THE Role of neuropeptides in the Pathogenesis of LIGAMENTO- and tendinopathies and their possible impact on TYPE of sonographic PATTERN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юрковский</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Yurkovskiy</surname><given-names>A. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Учреждение образования «Гомельский государственный медицинский университет»</institution></aff><aff xml:lang="en"><institution>omel State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>28</day><month>03</month><year>2018</year></pub-date><volume>0</volume><issue>1</issue><fpage>4</fpage><lpage>7</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Юрковский А.М., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Юрковский А.М.</copyright-holder><copyright-holder xml:lang="en">Yurkovskiy A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/211">https://journal.gsmu.by/jour/article/view/211</self-uri><abstract><p>Цель: оценить (по данным литературы) роль нейропептидов в патогенезе лигаменто- и тендинопатий, а также их возможное влияние на формирование патологического сонографического паттерна. Материалы и методы. Анализ публикаций, содержащих информацию о гистопатологии и лучевой семиотике повреждений связок и сухожилий, размещенных в ресурсах PubMed и российского информационного портала eLIBRARY.RU. Результаты . Определена возможная роль нейропептидов в формировании изменений, которые могут быть выявлены методами визуализации при лигаменто- и тендинопатиях . Заключение. Целесообразно дальнейшее изучение роли нейропептидов в патогенезе лигаменто- и тендинопатий с целью уточнения их роли в формировании и динамике изменений, выявляемых методами визуализации.</p></abstract><trans-abstract xml:lang="en"><p>Objective: to assess (according to the literature data) the role of neuropeptides in the pathogenesis of ligamento- and tendinopathies as well as their possible impact on formation of an abnormal sonographic pattern. Material and methods. Analysis of publications containing information about histopathology and radiation semiotics of injuries of ligaments and tendons which are stored in PubMed resources and the Russian news portal eLIBRARY.RU. Results. The possible role of neuropeptides in formation of changes that may be revealed by imaging methods in ligamento- and tendinopathies has been defined. Conclusion. It is rational to study the role of neuropeptides in the pathogenesis of ligamento- and tendinopathies in the future in order to clarify their role in the formation and dynamics of changes revealed by imaging methods.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лигаментопатия</kwd><kwd>тендинопатия</kwd><kwd>нейропептиды</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ligamentоpathy</kwd><kwd>tendinopathy</kwd><kwd>neuropeptides</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Жарков, П.Л. Остеохондроз и другие дистрофические изменения опорно-двигательной системы у взрослых и детей / П. Л. Жарков. - М.: Видар-М, 2009. - 375 с.</mixed-citation><mixed-citation xml:lang="en">Жарков, П.Л. Остеохондроз и другие дистрофические изменения опорно-двигательной системы у взрослых и детей / П. Л. Жарков. - М.: Видар-М, 2009. - 375 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Which prognostic factors for low back pain are generic predictors of outcome across a range of recovery domains? / C.E. Cook [et al.] // Phys. Ther. - 2013. - Vol.93, №1. - Р. 32-40.</mixed-citation><mixed-citation xml:lang="en">Which prognostic factors for low back pain are generic predictors of outcome across a range of recovery domains? / C.E. Cook [et al.] // Phys. Ther. - 2013. - Vol.93, №1. - Р. 32-40.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Миронов, С.П. Пояснично-крестцовый болевой синдром у спортсменов и артистов балета (диагностический алгоритм) / С.П. Миронов, Г.М. Бурмакова // Вестник РАМН. - 2008. - №8. - С. 8-12.</mixed-citation><mixed-citation xml:lang="en">Миронов, С.П. Пояснично-крестцовый болевой синдром у спортсменов и артистов балета (диагностический алгоритм) / С.П. Миронов, Г.М. Бурмакова // Вестник РАМН. - 2008. - №8. - С. 8-12.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ammer, K. Schmerzhaftes iliolumbalband: physiologischegrundlagen painful iliolumbar ligament: physiological foundations / K. Ammer // Manuelle Medizin. - 2010. - Vol. 48, № 2. -Р.141-144.</mixed-citation><mixed-citation xml:lang="en">Ammer, K. Schmerzhaftes iliolumbalband: physiologischegrundlagen painful iliolumbar ligament: physiological foundations / K. Ammer // Manuelle Medizin. - 2010. - Vol. 48, № 2. -Р.141-144.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">The sacroiliac joint: an overview of its anatomy, function and potential clinical implications / A.Vleeming [et al.] // J. Anat. - 2012. - Vol. 221, № 6. - P.537-567.</mixed-citation><mixed-citation xml:lang="en">The sacroiliac joint: an overview of its anatomy, function and potential clinical implications / A.Vleeming [et al.] // J. Anat. - 2012. - Vol. 221, № 6. - P.537-567.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Sacroiliac joint syndrome - description of pain etiology / A. Krawczyk-Wasielewska [et al.] // Europ. Scientific J. - 2014. - Vol.3. -Р.170-174.</mixed-citation><mixed-citation xml:lang="en">Sacroiliac joint syndrome - description of pain etiology / A. Krawczyk-Wasielewska [et al.] // Europ. Scientific J. - 2014. - Vol.3. -Р.170-174.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sandström, C. Peritendinitis calcarea: a common disease of middle life; its diagnosis, patology and treatment / C. Sandström // Am. J. Rentgenol. - 1938. - Vol.40. - P.1-21.</mixed-citation><mixed-citation xml:lang="en">Sandström, C. Peritendinitis calcarea: a common disease of middle life; its diagnosis, patology and treatment / C. Sandström // Am. J. Rentgenol. - 1938. - Vol.40. - P.1-21.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sandström, C. Calcifications of the intervertebral discs and the relationship between various types of calcifications in the soft tissues of the body/ С. Sandström // Acta radiol. - 1951. - Vol.36, №3. - Р. 217-233.</mixed-citation><mixed-citation xml:lang="en">Sandström, C. Calcifications of the intervertebral discs and the relationship between various types of calcifications in the soft tissues of the body/ С. Sandström // Acta radiol. - 1951. - Vol.36, №3. - Р. 217-233.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Hauser, R.A. Ligament injury and healing: an overview of current clinical concepts ligament injury and healing / R.A. Hauser, E.E. Dolan // J. Prolotherapy. -2011. - Vol.3, №4. - P. 836-846.</mixed-citation><mixed-citation xml:lang="en">Hauser, R.A. Ligament injury and healing: an overview of current clinical concepts ligament injury and healing / R.A. Hauser, E.E. Dolan // J. Prolotherapy. -2011. - Vol.3, №4. - P. 836-846.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Юрковский, А.М. Есть ли патологический континуум при повреждениях подвздошно-поясничной связки? / А.М. Юрковский // Проблемы здоровья и экологии. - 2012. - № 4. - С. 27-32.</mixed-citation><mixed-citation xml:lang="en">Юрковский, А.М. Есть ли патологический континуум при повреждениях подвздошно-поясничной связки? / А.М. Юрковский // Проблемы здоровья и экологии. - 2012. - № 4. - С. 27-32.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Neuropeptides: mediators of inflammation and tissue repair? / M. Schaffer [et al.] // Arch. Surg. - 1998. - Vol.133. - P.1107-1116.</mixed-citation><mixed-citation xml:lang="en">Neuropeptides: mediators of inflammation and tissue repair? / M. Schaffer [et al.] // Arch. Surg. - 1998. - Vol.133. - P.1107-1116.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">What do we mean by the term «inflammation»? A contemporary basic science update for sports medicine /A. Scott [et al.] // Br. J. Sports Med. - 2004. - Vol.38. - P. 372-380.</mixed-citation><mixed-citation xml:lang="en">What do we mean by the term «inflammation»? A contemporary basic science update for sports medicine /A. Scott [et al.] // Br. J. Sports Med. - 2004. - Vol.38. - P. 372-380.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Scott, A. Neuropeptides in tendinopathy / A. Scott, R. Bahr // Frontiers in Bioscience. - 2009. - Vol.14. - P. 2203-2211.</mixed-citation><mixed-citation xml:lang="en">Scott, A. Neuropeptides in tendinopathy / A. Scott, R. Bahr // Frontiers in Bioscience. - 2009. - Vol.14. - P. 2203-2211.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Danielson, P. Distribution of general (PGP 9.5) and sensory (substance P/CGRP) innervations in the human patellar tendon / P. Danielson, H. Alfredson, S.Forsgren // Knee Surg. Sports Traumatol. Arthrosc. - 2006. - Vol.14, №2.-P.125-132.</mixed-citation><mixed-citation xml:lang="en">Danielson, P. Distribution of general (PGP 9.5) and sensory (substance P/CGRP) innervations in the human patellar tendon / P. Danielson, H. Alfredson, S.Forsgren // Knee Surg. Sports Traumatol. Arthrosc. - 2006. - Vol.14, №2.-P.125-132.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Glutamate receptors in tendinopathic patients / N. Schizas [et al.] // J. Orthop. Res. - 2012. - Vol.30, №9. - Р. 1447-1452.</mixed-citation><mixed-citation xml:lang="en">Glutamate receptors in tendinopathic patients / N. Schizas [et al.] // J. Orthop. Res. - 2012. - Vol.30, №9. - Р. 1447-1452.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Expression of sensory neuropeptides in tendon is associated with failed healing and activity-related tendon pain in collagenase-induced tendon injury / P.P. Lui [et al.] // Am. J. Sports Med. - 2010. - Vol.38, №4. - Р. 757-764.</mixed-citation><mixed-citation xml:lang="en">Expression of sensory neuropeptides in tendon is associated with failed healing and activity-related tendon pain in collagenase-induced tendon injury / P.P. Lui [et al.] // Am. J. Sports Med. - 2010. - Vol.38, №4. - Р. 757-764.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Exposure-dependent increases in IL-1 beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury/ J.M. Fedorczyk [et al.] //J. Orthop. Res.- 2010.-Vol.28,№3.-P.298-307.</mixed-citation><mixed-citation xml:lang="en">Exposure-dependent increases in IL-1 beta, substance P, CTGF, and tendinosis in flexor digitorum tendons with upper extremity repetitive strain injury/ J.M. Fedorczyk [et al.] //J. Orthop. Res.- 2010.-Vol.28,№3.-P.298-307.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Danielson, P. Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man / P. Danielson, H. Alfredson, S. Forsgren // Microsc Res Tech. - 2007. - Vol.70, №4. - Р. 310-324.</mixed-citation><mixed-citation xml:lang="en">Danielson, P. Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man / P. Danielson, H. Alfredson, S. Forsgren // Microsc Res Tech. - 2007. - Vol.70, №4. - Р. 310-324.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Substance P is a mechanoresponsive, autocrine regulator of human tenocyte proliferation / L.J. Backman [et al.] // PLoS ONE. - 2011. - Vol.6, №11. - Р. 7209.</mixed-citation><mixed-citation xml:lang="en">Substance P is a mechanoresponsive, autocrine regulator of human tenocyte proliferation / L.J. Backman [et al.] // PLoS ONE. - 2011. - Vol.6, №11. - Р. 7209.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy - peptidergic elevation preceding tendinosis-like tissue changes / L.J. Backman [et al.] // J. Musculoskelet. Neuronal Interact. - 2011. - Vol.11, №2. - Р. 133-140.</mixed-citation><mixed-citation xml:lang="en">Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy - peptidergic elevation preceding tendinosis-like tissue changes / L.J. Backman [et al.] // J. Musculoskelet. Neuronal Interact. - 2011. - Vol.11, №2. - Р. 133-140.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Tenocyte hypercellularity and vascular proliferation in a rabbit model of tendinopathy: contralateral effects suggest the involvement of central neuronal mechanisms / G. Andersson [et al.] // Br. J. Sports Med. - 2011. - Vol.45, №5. - P. 399-406.</mixed-citation><mixed-citation xml:lang="en">Tenocyte hypercellularity and vascular proliferation in a rabbit model of tendinopathy: contralateral effects suggest the involvement of central neuronal mechanisms / G. Andersson [et al.] // Br. J. Sports Med. - 2011. - Vol.45, №5. - P. 399-406.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model / G.Andersson [et al.] // Br. J. Sports Med. - 2011. -Vol.45, №13. - P. 1017-1022.</mixed-citation><mixed-citation xml:lang="en">Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model / G.Andersson [et al.] // Br. J. Sports Med. - 2011. -Vol.45, №13. - P. 1017-1022.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Exogenously administered substance P and neutral endopeptidaseinhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing / P. Burssens [et al.] // Foot Ankle Int. - 2005. - Vol. 26, №13. - P. 832-839.</mixed-citation><mixed-citation xml:lang="en">Exogenously administered substance P and neutral endopeptidaseinhibitors stimulate fibroblast proliferation, angiogenesis and collagen organization during Achilles tendon healing / P. Burssens [et al.] // Foot Ankle Int. - 2005. - Vol. 26, №13. - P. 832-839.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Qualitative analysis of Substance P, NK1-receptor and nerve ingrowth in Substance P-treated ruptured rat Achilles tendon / A. Steyaert [et al.] // Acta Orthop. Belg. - 2010. - Vol.76. - P. 387-395.</mixed-citation><mixed-citation xml:lang="en">Qualitative analysis of Substance P, NK1-receptor and nerve ingrowth in Substance P-treated ruptured rat Achilles tendon / A. Steyaert [et al.] // Acta Orthop. Belg. - 2010. - Vol.76. - P. 387-395.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Danielson, P. Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis / P. Danielson, H. Alfredson, S. Forsgren // Microsc. Res. Tech. - 2006. - Vol. 69. - P. 808-819.</mixed-citation><mixed-citation xml:lang="en">Danielson, P. Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve-related cholinergic effects in chronic painful patellar tendon tendinosis / P. Danielson, H. Alfredson, S. Forsgren // Microsc. Res. Tech. - 2006. - Vol. 69. - P. 808-819.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Danielson, Р. Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man / P. Danielson, H. Alfredson, S. Forsgren // Microsc. Res. Tech. - 2007. - Vol.70, №4. - Р. 310-324.</mixed-citation><mixed-citation xml:lang="en">Danielson, Р. Studies on the importance of sympathetic innervation, adrenergic receptors, and a possible local catecholamine production in the development of patellar tendinopathy (tendinosis) in man / P. Danielson, H. Alfredson, S. Forsgren // Microsc. Res. Tech. - 2007. - Vol.70, №4. - Р. 310-324.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Danielson, Р. In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis / P. Danielson, H. Alfredson, S. Forsgren // Microsc. Res. Tech. - 2007. - Vol.70, №10. - Р. 908-911.</mixed-citation><mixed-citation xml:lang="en">Danielson, Р. In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis / P. Danielson, H. Alfredson, S. Forsgren // Microsc. Res. Tech. - 2007. - Vol.70, №10. - Р. 908-911.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Nerve-related characteristics of ventral paratendinous tissue in chronic Achilles tendinosis / G. Andersson [et al.] // Knee Surg. Sports Traumatol. Arthrosc. - 2007. - Vol.15, №10. - P. 1272-1279.</mixed-citation><mixed-citation xml:lang="en">Nerve-related characteristics of ventral paratendinous tissue in chronic Achilles tendinosis / G. Andersson [et al.] // Knee Surg. Sports Traumatol. Arthrosc. - 2007. - Vol.15, №10. - P. 1272-1279.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Norepinephrine-induced calcium signaling and expression of adrenoceptors in avian tendon cells / M.E. Wall [et al.] // Am. J. Physiol. Cell Physiol. - 2004. - Vol. 287, №4. - C. 912-918.</mixed-citation><mixed-citation xml:lang="en">Norepinephrine-induced calcium signaling and expression of adrenoceptors in avian tendon cells / M.E. Wall [et al.] // Am. J. Physiol. Cell Physiol. - 2004. - Vol. 287, №4. - C. 912-918.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells / J.A. Oben [et al.] // Biochem. Biophys. Res. Commun. - 2003. - Vol.300. - P. 172-177.</mixed-citation><mixed-citation xml:lang="en">Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells / J.A. Oben [et al.] // Biochem. Biophys. Res. Commun. - 2003. - Vol.300. - P. 172-177.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Scott, А. VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes / A. Scott, H. Alfredson, S. Forsgren // J. Orthop. Res. - 2008. - Vol.26, №5. - Р. 685-692.</mixed-citation><mixed-citation xml:lang="en">Scott, А. VGluT2 expression in painful Achilles and patellar tendinosis: evidence of local glutamate release by tenocytes / A. Scott, H. Alfredson, S. Forsgren // J. Orthop. Res. - 2008. - Vol.26, №5. - Р. 685-692.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">In vivo microdialysis and immunohistochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR1 receptors, but no signs of inflammation, in Jumper's knee / H. Alfredson [et al.] // J. Orthop. Res. -2001. - Vol.19, №5. - Р. 881-886.</mixed-citation><mixed-citation xml:lang="en">In vivo microdialysis and immunohistochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR1 receptors, but no signs of inflammation, in Jumper's knee / H. Alfredson [et al.] // J. Orthop. Res. -2001. - Vol.19, №5. - Р. 881-886.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment? / H. Alfredson [et al.] // Knee Surg. Sports Traumatol. Arthrosc. - 2001. - Vol.9, №2. - Р. 123-126.</mixed-citation><mixed-citation xml:lang="en">Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment? / H. Alfredson [et al.] // Knee Surg. Sports Traumatol. Arthrosc. - 2001. - Vol.9, №2. - Р. 123-126.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Pathogenesis of tendinopathies: inflammation or degeneration? /M. Abate [et al.] // Arthritis Res. Ther. - 2009. - Vol.11, №3. - Р.235.</mixed-citation><mixed-citation xml:lang="en">Pathogenesis of tendinopathies: inflammation or degeneration? /M. Abate [et al.] // Arthritis Res. Ther. - 2009. - Vol.11, №3. - Р.235.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Maffulli, N. Tendon Injuries: Basic Science and Clinical Medicine / Edited by N. Maffulli, P. Renstrom, W.B. Leadbetter // London: Springer, 2005. - P. 40-48.</mixed-citation><mixed-citation xml:lang="en">Maffulli, N. Tendon Injuries: Basic Science and Clinical Medicine / Edited by N. Maffulli, P. Renstrom, W.B. Leadbetter // London: Springer, 2005. - P. 40-48.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Modulation of aggrecan and ADAMTS expression in ovine tendinopathy induced by altered strain / М.М. Smith [et al.] // Arthritis Rheum. - 2008. - Vol.58, №4. - P. 1055-1066.</mixed-citation><mixed-citation xml:lang="en">Modulation of aggrecan and ADAMTS expression in ovine tendinopathy induced by altered strain / М.М. Smith [et al.] // Arthritis Rheum. - 2008. - Vol.58, №4. - P. 1055-1066.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">An opioid system in connective tissue: a study of achillestendon in the rat / P. W. Ackermann [et al.] // J. Histochem. Cytochem. -2001. - Vol.49. - P. 1387-1395.</mixed-citation><mixed-citation xml:lang="en">An opioid system in connective tissue: a study of achillestendon in the rat / P. W. Ackermann [et al.] // J. Histochem. Cytochem. -2001. - Vol.49. - P. 1387-1395.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Increased expression of cannabinoid CB1 receptors in achilles tendinosis / E. Björklund [et al.] // PLoS ONE. - 2011. - Vol.6, №9. - P. 24731.</mixed-citation><mixed-citation xml:lang="en">Increased expression of cannabinoid CB1 receptors in achilles tendinosis / E. Björklund [et al.] // PLoS ONE. - 2011. - Vol.6, №9. - P. 24731.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">The pain of tendinopathy: physiological or pathophysiological? / E. Rio [et al.] // Sports Med. - 2014. - Vol.44, №1. - Р. 9-23.</mixed-citation><mixed-citation xml:lang="en">The pain of tendinopathy: physiological or pathophysiological? / E. Rio [et al.] // Sports Med. - 2014. - Vol.44, №1. - Р. 9-23.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
