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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2016-13-2-7</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-1687</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>ФЕНОТИПЫ И СОСТОЯНИЯ БРОНХИАЛЬНОЙ АСТМЫ С НЕКОНТРОЛИРУЕМЫМ ТЕЧЕНИЕМ</article-title><trans-title-group xml:lang="en"><trans-title>PHENOTYPES AND STATES OF UNCONTROLLED BRONCHIAL ASTHMA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рузанов</surname><given-names>Д. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ruzanov</surname><given-names>D. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давидовская</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Davidovskaya</surname><given-names>E. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барановская</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranouskaya</surname><given-names>T. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шебушева</surname><given-names>Т. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Shebusheva</surname><given-names>T. T.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Буйневич</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Buynevich</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алешкевич</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Aleshkevich</surname><given-names>L. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гавриленко</surname><given-names>В. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Gavrilenko</surname><given-names>V. E.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Гомельский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Gomel State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Белорусская медицинская академия последипломного образования</institution></aff><aff xml:lang="en"><institution>Belarusian Medical Academy of Postgraduate Education</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Гомельская областная туберкулезная клиническая больница</institution></aff><aff xml:lang="en"><institution>Gomel Regional Clinical Hospital</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Минская областная клиническая больница</institution></aff><aff xml:lang="en"><institution>Minsk Regional Clinical Hospital</institution></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Брестская областная больница</institution></aff><aff xml:lang="en"><institution>Brest Regional Hospital</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2016</year></pub-date><volume>0</volume><issue>2</issue><fpage>34</fpage><lpage>38</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Рузанов Д.Ю., Давидовская Е.И., Барановская Т.В., Шебушева Т.Т., Буйневич И.В., Алешкевич Л.В., Гавриленко В.Э., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Рузанов Д.Ю., Давидовская Е.И., Барановская Т.В., Шебушева Т.Т., Буйневич И.В., Алешкевич Л.В., Гавриленко В.Э.</copyright-holder><copyright-holder xml:lang="en">Ruzanov D.Y., Davidovskaya E.I., Baranouskaya T.V., Shebusheva T.T., Buynevich I.V., Aleshkevich L.V., Gavrilenko V.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/1687">https://journal.gsmu.by/jour/article/view/1687</self-uri><abstract><p>Цель: на основании анализа причин неконтролируемого течения бронхиальной астмы (БА) выявить состояния и фенотипы, влияющие на эффективность терапии. Материал и методы. Комплексно обследованы 762 пациента обратившихся (направленных) в медицинские учреждения для оказания им специализированной пульмонологической помощи. Результаты. Определена частота встречаемости различных фенотипов и состояний астмы и степень риска неконтролируемого течения БА. Заключение. Наиболее высокий риск неконтролируемого течения наблюдается у пациентов с хронически сложной, дистальной и нестабильной БА, при отсутствии комплаенса, при нерациональной терапии, синдроме перекреста астма-ХОБЛ, при декомпенсированной хронической тяжелой патологии и критических ошибках в использовании дозирующих аэрозольных ингаляторов (ДАИ).</p></abstract><trans-abstract xml:lang="en"><p>Aim: analyzing the causes of the uncontrolled course of bronchial asthma (BA) to reveal the states and phenotypes influencing the efficiency of therapy. Material and methods. 762 patients seeking medical advice or referred for specialized pulmonogical aid have been comprehensively examined. Results. We have defined the prevalence of different phenotypes and states of asthma and the risk for the uncontrolled course of BA. Conclusion. Patients with chronically severe distal and unstable BA detect the highest risk for the uncontrolled course in the absence of compliance, in irrational therapy, asthma-COPD overlap syndrome, decompensated chronic severe pathology and critical mistakes in the application of dosage aerosol inhalators.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бронхиальная астма</kwd><kwd>уровень контроля</kwd><kwd>фенотип</kwd><kwd>bronchial asthma</kwd><kwd>control level</kwd><kwd>phenotype</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">International ERS/ATS Guidelines on Defenition, Evaluation and Treatment of Severe Astma / K. F. 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