The work describes a clinical case of performing palliative mastectomy for the medical purpose in a patient (ASA class III) using paravertebral blockade with intravenous sedation as anesthetic management. The application of paravertebral blockade helped to ensure safe anesthetic management for palliative mastectomy of the breast. The hemodynamic stability due to the blockade and the lack of any necessity for additional administration of any analgesics during surgery should also be noted.