<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2014-11-3-27</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-1537</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СЛУЧАЙ ИЗ КЛИНИЧЕСКОЙ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>НАШ ПЕРВЫЙ ОПЫТ ПРИМЕНЕНИЯ АКТИВИРОВАННОГО РЕКОМБИНАНТНОГО ТКАНЕВОГО АКТИВАТОРА ПЛАЗМИНОГЕНА (АЛЬТЕПЛАЗА) ПРИ ЛЕЧЕНИИ НОВОРОЖДЕННОГО РЕБЕНКА С КАТЕТЕР-АССОЦИИРОВАННЫМ ТРОМБОМ ПРАВОГО ПРЕДСЕРДИЯ</article-title><trans-title-group xml:lang="en"><trans-title>OUR FIRST APPLICATION OF RECOMBINAN TISSUE PLASMINOGEN ACTIVATOR IN TREATMENT FOR A NEWBORN CHILD WITH CATHETER-ASSOCIATED TROMB OF THE RIGHT ATRIUM</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карамышев</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Karamyshev</surname><given-names>A. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Гомельская областная клиническая больница</institution></aff><aff xml:lang="en"><institution>Gomel Regional Clinical Hospital</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2014</year></pub-date><volume>0</volume><issue>3</issue><fpage>134</fpage><lpage>139</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Карамышев А.М., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Карамышев А.М.</copyright-holder><copyright-holder xml:lang="en">Karamyshev A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/1537">https://journal.gsmu.by/jour/article/view/1537</self-uri><abstract><p>Данный случай произошел на базе Учреждения здравоохранения «Гомельская областная клиническая больница». Ребенок, родившийся в Гомельском областном роддоме, в первые сутки жизни перенес: операцию по жизненным показаниям, массивную кровопотерю, геморрагический шок, синдром внутрисосудистого диссеминированного свертывания крови, синдром полиорганной недостаточности. В дальнейшем у пациента образовался катетер-ассоциированный тромб правого предсердия с клиникой тромбоэмболии легочной артерии [1, 2, 3, 5] Мы не имели клинического опыта по вопросу тромболитической терапии у новорожденных, перенесших геморрагический шок. Каких-либо стандартных рекомендаций, описаний подобных случаев в информационных ресурсах не найдено. Новорожденный получил тканевой, рекомбинантный активатор плазминогена, и позже мы удалили центральный венозный катетер с остатками организованного тромба. Тромболизис тканевым рекомбинатным активатором плазминогена был успешным, при отсутствии каких-либо осложнений. Ребенок в удовлетворительном состоянии выписан из стационара.</p></abstract><trans-abstract xml:lang="en"><p>The article presents a case of a baby born at the Gomel Regional Clinical Hospital in 2013. The baby, born at the Gomel Regional Maternity Hospital had surgery according to life indications, severe blood loss, hemorragic shock, disseminated intravascular clotting and syndrome of multiorgan disfunction. The patient later developed a large catheter-associated trombus of the right atrium with pulmonary embolism. [1, 2, 3, 5]. We did not have any clinical experience on trombolytic therapy in newborns after hemorragic shock. We could not find any standard recommendations, descriptions of similar cases in information resources. The newborn received a recombinant tissue plasminogen activator and later we removed the central venous catheter with the remains of the trombus. The trombolysis with the recombinant tissue plasminogen activator was successful and without any complications. The baby survived and was discharged from the hospital.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>альтеплаза</kwd><kwd>тромболизис</kwd><kwd>ребенок</kwd><kwd>катетер-ассоциированный тромб</kwd><kwd>внутрисердечный тромбоз</kwd><kwd>послеоперационный тромболизис</kwd><kwd>trombolysis</kwd><kwd>newborn child</kwd><kwd>catheter-associated trombus</kwd><kwd>intracardiotrombosis</kwd><kwd>recombinant tissue plasminogen activator</kwd><kwd>postoperative trombolysis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kronik, G. The European cooperative study group on the clinical significance of right heart thrombi / G. Kronik // Eur Heart J. - 1989. - Vol. 10. - Р. 1046-1059.</mixed-citation><mixed-citation xml:lang="en">Kronik, G. The European cooperative study group on the clinical significance of right heart thrombi / G. Kronik // Eur Heart J. - 1989. - Vol. 10. - Р. 1046-1059.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Importance of transthoracic two-dimensional echocardiography for the diagnosis and management of pulmonary embolism / V. M. Conraads [et al.] // Eur Heart J. - 1994. - Vol. 15. - P. 404-406.</mixed-citation><mixed-citation xml:lang="en">Importance of transthoracic two-dimensional echocardiography for the diagnosis and management of pulmonary embolism / V. M. Conraads [et al.] // Eur Heart J. - 1994. - Vol. 15. - P. 404-406.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Life-threatening pulmonary embolism with right-sided heart thrombus / C. d’Ivernois [et al.] // Chest. - 1994. - Vol. 105(4). - P. 1291-1292.</mixed-citation><mixed-citation xml:lang="en">Life-threatening pulmonary embolism with right-sided heart thrombus / C. d’Ivernois [et al.] // Chest. - 1994. - Vol. 105(4). - P. 1291-1292.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Transthoracic echocardiography documents prompt resolution of right atrial thrombus after thrombolytic therapy / K. S. Lee [et al.] // J. American society echocardiography. - 1992. - Vol. 5. - P. 541-543.</mixed-citation><mixed-citation xml:lang="en">Transthoracic echocardiography documents prompt resolution of right atrial thrombus after thrombolytic therapy / K. S. Lee [et al.] // J. American society echocardiography. - 1992. - Vol. 5. - P. 541-543.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Janssens, U. Successful thrombolysis of right atrial and ventricle thrombi in a patient with peripartum cardiomyopathy and extensive thromboembolism / U. Janssens, G. Klues, P. Hanrath // Heart. - 1997. - Vol. 78. - P. 515-516.</mixed-citation><mixed-citation xml:lang="en">Janssens, U. Successful thrombolysis of right atrial and ventricle thrombi in a patient with peripartum cardiomyopathy and extensive thromboembolism / U. Janssens, G. Klues, P. Hanrath // Heart. - 1997. - Vol. 78. - P. 515-516.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
