zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2014-11-3-1zdor-1511Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESЛЕКАРСТВЕННЫЕ СРЕДСТВА КАК ИНДУКТОРЫ СИНДРОМА СТИВЕНСА-ДЖОНСОНА - ТОКСИЧЕСКОГО ЭПИДЕРМАЛЬНОГО НЕКРОЛИЗА У ДЕТЕЙDRUGS AS INDUCERS OF STEVENS-JOHNSON SYNDROME - TOXIC EPIDERMAL NECROLYSIS IN CHILDRENДюбковаТ. П.DyubkovaT. P.noemail@neicon.ruЖерносекВ. Ф.ZhernosekV. F.noemail@neicon.ruБелорусский государственный университет, г. МинскBelarusian State University, MinskБелорусская медицинская академия последипломного образования, г. МинскBelarusian Medical Academy of Post-Graduate Education, Minsk20142809201403715Copyright © Дюбкова Т.П., Жерносек В.Ф., 20142014Дюбкова Т.П., Жерносек В.Ф.Dyubkova T.P., Zhernosek V.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/1511

В обзоре представлены причины и клинические проявления синдрома Стивенса-Джонсона - токсического эпидермального некролиза (ССД - ТЭН) у детей. Анализируется роль лекарственных средств как индукторов болезни. Высокий риск ССД - ТЭН у детей ассоциирован с ко-тримоксазолом (сульфаметоксазол + триметоприм), другими сульфаниламидами, применяемыми для лечения бактериальных инфекций, противосудорожными средствами (фенобарбитал, карбамазепин, ламотригин), нестероидными противовоспалительными средствами, прежде всего оксикамами. Наибольший риск развития ССД - ТЭН существует в течение первых 8 недель лечения c последующим резким снижением. К развитию ССД - ТЭН предрасполагают некоторые генетические факторы.

The review presents causes and clinical features of Stevens-Johnson syndrome, toxic epidermal necrolysis (SJS/TEN), in children and analyzes the role of drugs as inducers of the illness. The high risk of SJS/TEN in children is associated with co-trimoxazol (sulfamethoxazol + trimethoprim), other anti-infective sulfonamides, anticonvulsants (phenobarbital, carbamazepin, lamotrigine), non-steroidal anti-inflammatory drugs of the oxicam-type. The highest risk of SJS/TEN development occurs during the first eight weeks of treatment with a subsequent sharp decrease in the incidence rate. Certain genetic factors contribute to SJS/TEN development.

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The authors declare that there are no conflicts of interest present.