zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2014-11-2-7zdor-1487Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEВЛИЯНИЕ I/D ПОЛИМОРФИЗМА ГЕНА АНГИОТЕНЗИН-ПРЕВРАЩАЮЩЕГО ФЕРМЕНТА НА ДИАБЕТИЧЕСКУЮ НЕФРОПАТИЮEFFECT OF ANGIOTENSIN-CONVERTING ENZYME GENE I/D POLYMORPHISM ON NEPHROPATHY IN DIABETIC PATIENTSВасильковаО. Н.VasilkovaO. N.noemail@neicon.ruСилинА. Е.SilinA. E.noemail@neicon.ruМартинковВ. Н.MartinkovV. N.noemail@neicon.ruТропашкоИ. Б.TropashkoI. B.noemail@neicon.ruЗекеноваК. К.ZekenovaK. K.noemail@neicon.ruЖмайликМ. В.ZhmailikM. V.noemail@neicon.ruМохортТ. В.MokhortT. V.noemail@neicon.ruГомельский государственный медицинский университетGomel State Medical UniversityРеспубликанский научно-практический центр радиационной медицины и экологии человека, г. ГомельRepublican Research Centre for Radiation Medicine and Human Ecology, GomelБелорусский государственный медицинский университет, г. МинскBelarusian State Medical University, Minsk201428062014023540Copyright © Василькова О.Н., Силин А.Е., Мартинков В.Н., Тропашко И.Б., Зекенова К.К., Жмайлик М.В., Мохорт Т.В., 20142014Василькова О.Н., Силин А.Е., Мартинков В.Н., Тропашко И.Б., Зекенова К.К., Жмайлик М.В., Мохорт Т.В.Vasilkova O.N., Silin A.E., Martinkov V.N., Tropashko I.B., Zekenova K.K., Zhmailik M.V., Mokhort T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/1487

Цель: изучение связи I/D полиморфизма гена ангиотензин-превращающего фермента (АПФ) и диабетической нефропатии (ДН). Методы. Проанализирован I/D полиморфизм гена АПФ у 58 пациентов с сахарным диабетом 2 типа. Результаты. Не было выявлено достоверных различий в частоте выявления DD генотипа и D аллели у пациентов с ДН и без ДН (40,9 и 52,3 %, 19,4 и 41,7 % соответственно) (p = 0,076, ОШ = 0,313, 95 % ДИ = 0,084-1,164 для DD и p = 0,266, ОШ = 0,631, 95 % ДИ = 0,303-1,312 для D). Выводы. При сравнении результатов генотипирования пациентов с ДН и без ДН не были выявлены отличия в распределении аллелей и генотипов гена АПФ.

Aim: to study the relation of angiotensin-converting enzyme ACE (I/D) in genetic susceptibility of diabetic nephropathy (DN). Methods. I/D polymorphism of ACE gene was studied in 58 patients with diabetes type 2. Results. There are no reliable differences in detection of DD genotype and D allele in patients with DN and without DN (40,9 and 52,3 %, 19,4 and 41,7 %, respectively) (p = 0,076, LR = 0,313, 95 % DI = 0,084-1,164 for DD and p = 0,266, LR = 0,631, 95 % DI = 0,303-1,312 for D). Conclusion. The comparison of the results of genotyping in patients with and without DN did not reveal any differences in distribution of allele and ACE genotypes.

сахарный диабетдиабетическая нефропатиягенdiabetes mellitusdiabetic nephropathygeneReferencesThe D allele of the ACE/ ID common gene variant is associated with T2D mellitus in Caucasian subjects / J. W. Stephens [et al.] // Molgenet Metab. - 2005. - Vol. 84. - P. 83-88.The D allele of the ACE/ ID common gene variant is associated with T2D mellitus in Caucasian subjects / J. W. Stephens [et al.] // Molgenet Metab. - 2005. - Vol. 84. - P. 83-88.Angiotensin II type 2 recepter gene polymorphisms and essential hypertension / Yi. Z. Kui-xing [et al.] // Acta Pharmacol Sin. - 2003. - Vol. 24, № 11. - P. 1089-1090.Angiotensin II type 2 recepter gene polymorphisms and essential hypertension / Yi. Z. Kui-xing [et al.] // Acta Pharmacol Sin. - 2003. - Vol. 24, № 11. - P. 1089-1090.Insertion/deletion polymorphism of the ACE gene is associated with T2D / Yo. Feng [et al.] // Diabetes. - 2002. - Vol. 51. - P. 1986-1988.Insertion/deletion polymorphism of the ACE gene is associated with T2D / Yo. Feng [et al.] // Diabetes. - 2002. - Vol. 51. - P. 1986-1988.The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk / J. A. Staessen [et al.] // J Hypertens. - 1997. - Vol. 15. - P. 1579-1592.The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk / J. A. Staessen [et al.] // J Hypertens. - 1997. - Vol. 15. - P. 1579-1592.The angiotensin-converting enzyme DD genotype is associated with glomerulopathy lesions in T2D / H. Solini [et al.] // Diab. - 2002. - Vol. 51, № 1. - P. 251-255.The angiotensin-converting enzyme DD genotype is associated with glomerulopathy lesions in T2D / H. Solini [et al.] // Diab. - 2002. - Vol. 51, № 1. - P. 251-255.Long-term glycemic control and the rate of progression of early diabetic kidney disease / R. E. Gibert [et al.] // Kidney Int. - 2000. - Vol. 44. - P. 855-859.Long-term glycemic control and the rate of progression of early diabetic kidney disease / R. E. Gibert [et al.] // Kidney Int. - 2000. - Vol. 44. - P. 855-859.Association between the angiotensin-converting enzyme- insertion/deletion polymorphism and diabetic nephropathy / R. Kunz [et al.] // J AM Soc Nephrol. - 2000. - Vol. 9. - P. 1653-1663.Association between the angiotensin-converting enzyme- insertion/deletion polymorphism and diabetic nephropathy / R. Kunz [et al.] // J AM Soc Nephrol. - 2000. - Vol. 9. - P. 1653-1663.Relationship between polymorphisms of angiotensin-converting enzyme gene insertion/deletion, endothelial nitric oxide synthase gene intron 4 VNTR and risk for cervical cancer / J. G. Han [et al.] // Life Science Journal. - 2012. - Vol. 9, № 2. - P. 100-104.Relationship between polymorphisms of angiotensin-converting enzyme gene insertion/deletion, endothelial nitric oxide synthase gene intron 4 VNTR and risk for cervical cancer / J. G. Han [et al.] // Life Science Journal. - 2012. - Vol. 9, № 2. - P. 100-104.Diabetic Nephropathy in T2D prevention and patient management / G. Wolf [et al.] // JAM Soc NePhrol. - 2003. - Vol. 14. - P. 1396-1405.Diabetic Nephropathy in T2D prevention and patient management / G. Wolf [et al.] // JAM Soc NePhrol. - 2003. - Vol. 14. - P. 1396-1405.The renin-angiotensin system in the patient with diabetes / N. K. Hellenberg [et al.] // AM J Clin Proc. - 2003. - Vol. 3. - P. 15-20.The renin-angiotensin system in the patient with diabetes / N. K. Hellenberg [et al.] // AM J Clin Proc. - 2003. - Vol. 3. - P. 15-20.Genetic determinants of diabetic nephropathy / R. C. Elston [et al.] // Am Soc Nephrolo. - 2003. - Vol. 14. - P. 202-204.Genetic determinants of diabetic nephropathy / R. C. Elston [et al.] // Am Soc Nephrolo. - 2003. - Vol. 14. - P. 202-204.Mechanism of angiotensin II- Induced proteinuria in the rat / H. Hermp [et al.] // Am J Physiol. - 2000. - Vol. 233, № 1. - P. 13-21.Mechanism of angiotensin II- Induced proteinuria in the rat / H. Hermp [et al.] // Am J Physiol. - 2000. - Vol. 233, № 1. - P. 13-21.ACE gene polymorphism in NIDD and its relationship with diabetic nephropathy / B. W. Jeffers [et al.] // Licdney Int. - 1997. - Vol. 52. - P. 473-477.ACE gene polymorphism in NIDD and its relationship with diabetic nephropathy / B. W. Jeffers [et al.] // Licdney Int. - 1997. - Vol. 52. - P. 473-477.Genetics of the renin-angiotensin converting enzyme and renal disease / S. Schmidt [et al.] // Curr opin Nephrol Hypertens. - 1997. - Vol. 6. - P. 146-151.Genetics of the renin-angiotensin converting enzyme and renal disease / S. Schmidt [et al.] // Curr opin Nephrol Hypertens. - 1997. - Vol. 6. - P. 146-151.Relationship between serum ACE activity and diabetic nephropathy in patients with type II diabetes / L. Liao [et al.] // Hunan Yike Dayue Xue Bao. - 1999. - Vol. 24. - P. 263-266.Relationship between serum ACE activity and diabetic nephropathy in patients with type II diabetes / L. Liao [et al.] // Hunan Yike Dayue Xue Bao. - 1999. - Vol. 24. - P. 263-266.

The authors declare that there are no conflicts of interest present.