References

zdor

Проблемы здоровья и экологии

Health and Ecology Issues

2220-09672708-6011

Gomel State Medical University

10.51523/2708-6011.2013-10-2-2

zdor-1361

Research Article

ОБЗОРЫ И ЛЕКЦИИ

REVIEWS AND LECTURES

БИОЛОГИЧЕСКАЯ РОЛЬ ЦИНКА ПРИ АЛКОГОЛЬНОМ И ВИРУСНОМ ПОРАЖЕНИЯХ ПЕЧЕНИ (обзор литературы)

BIOLOGICAL ROLE OF ZINC IN ALCOHOLIC AND VIRAL LIVER LESION (literature review)

Шейбак

В. М.

Sheibak

V. M.

noemail@neicon.ru

Горецкая

М. В.

Goretskaya

M. V.

noemail@neicon.ru

Павлюковец

А. Ю.

Pavliukovets

A. Yu.

noemail@neicon.ru

Гродненский государственный медицинский университетGrodno State Medical University

2013

28062013

021420

2013

Шейбак В.М., Горецкая М.В., Павлюковец А.Ю.

Sheibak V.M., Goretskaya M.V., Pavliukovets A.Y.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.gsmu.by/jour/article/view/1361

Цинк - необходимый микроэлемент для нормального роста клеток, их развития и дифференциации, является компонентом каталитического центра более чем 300 ферментов, определяет структуру факторов транскрипции, участвуя, таким образом, в синтезе ДНК, РНК, делении клеток. Основным органом, участвующим в метаболизме цинка в организме, является печень. Эндогенная недостаточность цинка развивается при хронических заболеваниях печени: алкогольном стеатогепатите и хроническом вирусном гепатите В или С, особенно в случае развития цирроза печени. Многочисленными исследованиями показана целесообразность включения препаратов цинка в стандартные протоколы лечения гепатита. Назначение цинка в комбинации с пегилированными интерферонами более эффективно при хроническом вирусном гепатите C, чем лечение одним интерфероном.

Zinc being a microelement necessary for normal cell growth, its development and differentiation is a component of the catalytic site of more than 300 enzymes and determines the structure of transcription factors, thereby participating in the synthesis of DNA, RNA, and cell division. Liver is the main organ involved in the metabolism of zinc. The endogenous zinc deficiency develops in chronic liver diseases such as alcoholic steatohepatitis, chronic viral hepatitis B or C and, especially in liver cirrhosis. Numerous studies have shown the advisability of including zinc supplements to standard hepatitis treatment protocols. Zinc combined with pegylated interferon and prescribed to patients with chronic viral hepatitis C is more effective, than interferon by itself.

цинкпеченьалкогольный стеатогепатитхронический гепатит С и Вzincliveralcoholic steatohepatitischronic hepatitis C and B

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The authors declare that there are no conflicts of interest present.