zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2013-10-1-5zdor-1334Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESГЕПАТОЦИТАРНАЯ ДИФФЕРЕНЦИРОВКА МЕЗЕНХИМАЛЬНЫХ СТВОЛОВЫХ КЛЕТОК (обзор литературы)HepatocytIC differentiation of mesenchymal stem cells (literature review)СкуратовА. Г.SkuratovA. G.noemail@neicon.ruПетреневД. Р.PetrenyovD. R.noemail@neicon.ruКондрачукА. Н.KondrachukA. N.noemail@neicon.ruГомельский государственный медицинский университетGomel State Medical University201328032013012935Copyright © Скуратов А.Г., Петренев Д.Р., Кондрачук А.Н., 20132013Скуратов А.Г., Петренев Д.Р., Кондрачук А.Н.Skuratov A.G., Petrenyov D.R., Kondrachuk A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/1334

По данным ВОЗ, заболевания печени различной этиологии являются одной из 10 основных причин смертности в мире. Трансплантация печени и использование ее биоинженерных аналогов лимитировано высокими затратами и побочными эффектами лечения, а также объективной ограниченностью источников донорских органов и функциональных клеточных элементов. Применение инновационных подходов направленной дифференцировки мезенхимальных стволовых клеток может помочь преодолеть многие недостатки существующих методов лечения. В представленной обзорной статье рассматриваются основные источники, особенности дифференцировки и аспекты безопасности использования мезенхимальных стволовых клеток в лечении печеночной недостаточности.

The data of WHO indicate that liver diseases of different etiology are one of the 10 most frequent death causes in the world. Liver transplantation and use of its bioengineered analogs are limited by their high cost and adverse effects of the treatment, as well as by limited availability of donor organs and functional cellular elements. The application of innovative approaches of directed differentiation of mesenchyme stem cells can help overcome the shortcomings of current treatment methods. The present literature review covers the main sources, particularities of differentiation and safety aspects of the application of mesenchymal stem cell in the treatment of hepatic failure.

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The authors declare that there are no conflicts of interest present.