zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2012-9-3-9zdor-1280Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESКОИНФИЦИРОВАНИЕ ВИРУСОМ ПАПИЛЛОМЫ ЧЕЛОВЕКА ВИЧ-ПОЗИТИВНЫХ ЖЕНЩИН (обзор литературы)CO-INFECTION WITH HUMAN PAPILLOMA VIRUS OF HIV-POSITIVE WOMEN (literature review)ТесловаО. А.TeslovaO. A.noemail@neicon.ruГомельский государственный медицинский университетGomel State Medical University201228092012034449Copyright © Теслова О.А., 20122012Теслова О.А.Teslova O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/1280

Цель. По данным научных публикаций изучить частоту ВПЧ-инфекции половых органов у ВИЧ-инфицированных женщин, взаимное влияние, проявления и исходы у ВПЧ-ВИЧ-коинфицированных пациенток, в том числе во время беременности и после родов. Материал и методы. Проведен обзор современных отечественных и зарубежных исследований по проблеме коинфицирования женщин ВПЧ и ВИЧ. Результаты. В статье приведены данные о частоте ВПЧ-инфекции гениталий и характеристика типов папилломавирусов у ВИЧ-позитивных пациенток, связь ВПЧ-инфицирования с иммунными нарушениями, влияние антиретровирусной терапии на персистенцию ВПЧ в половых путях. Уделено внимание проблемам папилломавирусной инфекции у ВИЧ-инфицированных беременных и перинатальной передачи ВПЧ. Заключение. ВИЧ-инфицированные женщины формируют группу повышенного риска папилломавирусной инфекции. Разработка и внедрение алгоритмов динамического гинекологического наблюдения за пациентками, коинфицированными ВПЧ и ВИЧ, помогут своевременно выявлять и предотвращать развитие рака шейки матки, снижать смертность от этого заболевания. Исследования ВПЧ-ВИЧ-коинфицированных пациенток во время беременности и после родов позволят разработать меры профилактики вертикального инфицирования, установить ближайшие и отдаленные исходы для матерей и детей, прогноз развития ВПЧ- и ВИЧ-ассоциированных заболеваний.

Aim. To study the prevalence of genital HPV infection in HIV-positive women and their mutual influence, their manifestations and outcomes in co-infected HPV- and HIV-positive patients, including the period during their pregnancy and after the childbirth according to scientific publications. Material and methods. Present-day national and international research works on female HPV and HIV co-infection were reviewed. Results. The article presents the data on genital HPV-infection prevalence and characterization of HPV types in HIV-positive patients, the relation of HPV-infection with immune disorders, the effect of antiretroviral therapy on HPV persistence in genital tracts. The problems of HPV infection in HIV-infected pregnant women and HPV perinatal transmission were also considered in the work. Conclusion. HIV-positive women form a high-risk group for HPV infection. The development and implementation of algorithms for dynamic gynecological supervision in HIV and HPV co-infected patients will help to reveal and prevent cervical cancer prevalence and reduce its mortality. The examination of HPV and HIV co-infected pregnant and parturient patients will make it possible to prevent vertical transmission; determine the immediate and long-term outcomes for mothers and children, the prognosis of HPV- and HIV-associated diseases.

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The authors declare that there are no conflicts of interest present.