<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2012-9-3-7</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-1278</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ И ПОЗИЦИИ ДОКАЗАТЕЛЬНОЙ МЕДИЦИНЫ В ВОПРОСЕ ПЕРИОПЕРАЦИОННОГО ВЕДЕНИЯ ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ</article-title><trans-title-group xml:lang="en"><trans-title>CLINICAL GUIDELINES AND EVIDENCE REGARDING PERIOPERATIVE MANAGEMENT OF PATIENTS WITH DIABETES MELLITUS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Платошкин</surname><given-names>Н. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Platoshkin</surname><given-names>N. E.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Канус</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kanus</surname><given-names>I. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Гомельский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Gomel State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Белорусская медицинская академия последипломного образования, Минск</institution></aff><aff xml:lang="en"><institution>Belarusian Medical Academy of Postgraduate Education, Minsk</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2012</year></pub-date><volume>0</volume><issue>3</issue><fpage>35</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Платошкин Н.Э., Канус И.И., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Платошкин Н.Э., Канус И.И.</copyright-holder><copyright-holder xml:lang="en">Platoshkin N.E., Kanus I.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/1278">https://journal.gsmu.by/jour/article/view/1278</self-uri><abstract><p>Цель: обзор клинических рекомендаций и доказательной базы, регламентирующих периоперационное ведение пациентов с сахарным диабетом. Материалы и методы: изучены литературные источники, содержащие доказательные основы, а также данные клинических рекомендаций по периоперационному ведению пациентов, страдающих сахарным диабетом. Описываются и анализируются подходы к предоперационной подготовке, периоперационной инсулинотерапии у данной категории пациентов. Обсуждается роль пероральных гипогликемизирующих лекарственных средств в периоперационном периоде. Заключение. Оптимальное периоперационное ведение пациентов, страдающих сахарным диабетом, является сложной задачей. Существующая на сегодняшний день доказательная база освещает далеко не все проблемы, возникающие в ходе работы с данной категорией пациентов. Очевидна необходимость проведения дальнейших исследований в этой области и разработка рекомендаций для практической работы.</p></abstract><trans-abstract xml:lang="en"><p>Aim of research: the aim of this research was to overview clinical guidelines and evidence regarding perioperative management of patients with diabetes mellitus. Materials and methods: the clinical guidelines and evidence regarding perioperative management of patients with diabetes mellitus were studied. The approaches to preoperative management and perioperative insulin therapy in this category of patients were described and analyzed. The role of oral hypoglycemic drugs in perioperative period was discussed. Conclusion. The optimal perioperative management of patients with diabetes mellitus is a difficult task. The up-to-date evidence does not cover all the problems arising during the management of this category of patients. The need in further research and compilation of clinical guidelines is obvious.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сахарный диабет</kwd><kwd>предоперационная подготовка</kwd><kwd>периоперационный период</kwd><kwd>инсулинотерапия</kwd><kwd>diabetes mellitus</kwd><kwd>preoperative management</kwd><kwd>perioperative period</kwd><kwd>insulin therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Meneghini, L. F. Perioperative management of diabetes: translating evidence into practice / L. F. Meneghini // Cleveland Clinic Journal of Medicine. - 2009. - Vol. 76, № 4. - P. 53-59.</mixed-citation><mixed-citation xml:lang="en">Meneghini, L. F. Perioperative management of diabetes: translating evidence into practice / L. F. Meneghini // Cleveland Clinic Journal of Medicine. - 2009. - Vol. 76, № 4. - P. 53-59.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hoogwerf, B. J. Perioperative management of diabetes mellitus: how should we act on the limited evidence? / B. J. Hoogwerf // Cleveland Clinic Journal of Medicine. - 2006. - Vol. 73, № 1. - P. 95-99.</mixed-citation><mixed-citation xml:lang="en">Hoogwerf, B. J. Perioperative management of diabetes mellitus: how should we act on the limited evidence? / B. J. Hoogwerf // Cleveland Clinic Journal of Medicine. - 2006. - Vol. 73, № 1. - P. 95-99.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Increased preoperative glucose levels are associated with perioperative mortality in patients undergoing noncardiac, nonvascular surgery / P. Noordzij [et al.] // European Journal of Endocrinology. - 2007. - Vol. 156, № 1. - P. 137-142.</mixed-citation><mixed-citation xml:lang="en">Increased preoperative glucose levels are associated with perioperative mortality in patients undergoing noncardiac, nonvascular surgery / P. Noordzij [et al.] // European Journal of Endocrinology. - 2007. - Vol. 156, № 1. - P. 137-142.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Relationship of perioperative hyperglycemia and postoperative infections in patients who undergo general and vascular surgery / M. Ramos [et al.] // Annals of Surgery. - 2008. - Vol. 248, № 4. - P. 585-591.</mixed-citation><mixed-citation xml:lang="en">Relationship of perioperative hyperglycemia and postoperative infections in patients who undergo general and vascular surgery / M. Ramos [et al.] // Annals of Surgery. - 2008. - Vol. 248, № 4. - P. 585-591.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Relationship between perioperative glycemic control and postoperative infections / K. Hanazaki [et al.] // World Journal of Gastroenterology. - 2009. - Vol. 15, № 33. - P. 4122-4125.</mixed-citation><mixed-citation xml:lang="en">Relationship between perioperative glycemic control and postoperative infections / K. Hanazaki [et al.] // World Journal of Gastroenterology. - 2009. - Vol. 15, № 33. - P. 4122-4125.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Elevated preoperative hemoglobin A1c level is predictive of adverse events after coronary artery bypass surgery / M. Halkos [et al.] // The Journal of Thoracic and Cardiovascular Surgery. - 2008. - Vol. 136, № 3. - P. 631-640.</mixed-citation><mixed-citation xml:lang="en">Elevated preoperative hemoglobin A1c level is predictive of adverse events after coronary artery bypass surgery / M. Halkos [et al.] // The Journal of Thoracic and Cardiovascular Surgery. - 2008. - Vol. 136, № 3. - P. 631-640.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.) Group. Glycosylated hemoglobin levels and outcome in non-diabetic cardiac surgery patients / C. Hudson [et al.] // Canadian Journal of Anesthesia. - 2010. - Vol. 57, № 6. - P. 565-572.</mixed-citation><mixed-citation xml:lang="en">Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.) Group. Glycosylated hemoglobin levels and outcome in non-diabetic cardiac surgery patients / C. Hudson [et al.] // Canadian Journal of Anesthesia. - 2010. - Vol. 57, № 6. - P. 565-572.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">HaemoglobinA1c (HbA1C) in non-diabetic and diabetic vascular patients. Is HbA1C an independent risk factor and predictor of adverse outcome? / C. O'Sullivan [et al.] // European Journal of Vascular and Endovascular Surgery. - 2006. - Vol. 32, № 2. - P. 188-197.</mixed-citation><mixed-citation xml:lang="en">HaemoglobinA1c (HbA1C) in non-diabetic and diabetic vascular patients. Is HbA1C an independent risk factor and predictor of adverse outcome? / C. O'Sullivan [et al.] // European Journal of Vascular and Endovascular Surgery. - 2006. - Vol. 32, № 2. - P. 188-197.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Long-term glycemic control and postoperative infectious complications / A. Dronge [et al.] // Archives of Surgery. - 2006. - Vol. 141, № 4. - P. 375-380.</mixed-citation><mixed-citation xml:lang="en">Long-term glycemic control and postoperative infectious complications / A. Dronge [et al.] // Archives of Surgery. - 2006. - Vol. 141, № 4. - P. 375-380.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Glycemic control and infections in patients with diabetes undergoing noncardiac surgery / J. King [et al.] // Annals of Surgery. - 2011. - Vol. 253, № 1. - P. 158-165.</mixed-citation><mixed-citation xml:lang="en">Glycemic control and infections in patients with diabetes undergoing noncardiac surgery / J. King [et al.] // Annals of Surgery. - 2011. - Vol. 253, № 1. - P. 158-165.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes / H. Gerstein [et al.] // The New England Journal of Medicine. - 2008. - Vol. 358, № 24. - P. 2545-2559.</mixed-citation><mixed-citation xml:lang="en">Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes / H. Gerstein [et al.] // The New England Journal of Medicine. - 2008. - Vol. 358, № 24. - P. 2545-2559.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery) / M. Rizzo [et al.] // Diabetes Care. - 2011. - Vol. 34, № 2. - P. 256-261.</mixed-citation><mixed-citation xml:lang="en">Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery) / M. Rizzo [et al.] // Diabetes Care. - 2011. - Vol. 34, № 2. - P. 256-261.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">The Society of Thoracic Surgeons practice guideline series: Blood glucose management during adult cardiac surgery / H. Lazar [et al.] // The Annals of Thoracic Surgery. - 2009. - Vol. 87, № 2. - P. 663-669.</mixed-citation><mixed-citation xml:lang="en">The Society of Thoracic Surgeons practice guideline series: Blood glucose management during adult cardiac surgery / H. Lazar [et al.] // The Annals of Thoracic Surgery. - 2009. - Vol. 87, № 2. - P. 663-669.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Insulin absorption: a major factor in apparent insulin resistance and the control of type 2 diabetes mellitus / S. Friedberg [et al.] // Metabolism. - 2006. - Vol. 55, № 5. - P. 614-619.</mixed-citation><mixed-citation xml:lang="en">Insulin absorption: a major factor in apparent insulin resistance and the control of type 2 diabetes mellitus / S. Friedberg [et al.] // Metabolism. - 2006. - Vol. 55, № 5. - P. 614-619.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Алгоритмы специализированной медицинской помощи больным сахарным диабетом / И. И. Дедов [и др.] // Сахарный диабет. - 2011. - № 3. - C. 58-60.</mixed-citation><mixed-citation xml:lang="en">Алгоритмы специализированной медицинской помощи больным сахарным диабетом / И. И. Дедов [и др.] // Сахарный диабет. - 2011. - № 3. - C. 58-60.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Effect of hyperglycemia and continuous intravenous insulin infusions on outcomes of cardiac surgical procedures: the Portland Diabetic Project / A. Furnary [et al.] // Endocrine Practice. - 2004. - Vol. 10, № 2. - P. 21-33.</mixed-citation><mixed-citation xml:lang="en">Effect of hyperglycemia and continuous intravenous insulin infusions on outcomes of cardiac surgical procedures: the Portland Diabetic Project / A. Furnary [et al.] // Endocrine Practice. - 2004. - Vol. 10, № 2. - P. 21-33.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Society for Ambulatory Anesthesia consensus statement on perioperative blood glucose management in diabetic patients undergoing ambulatory surgery / G. Joshi [et al.] // Anesthesia &amp; Analgesia. - 2010. - Vol. 111, № 6. - P. 1378-1387.</mixed-citation><mixed-citation xml:lang="en">Society for Ambulatory Anesthesia consensus statement on perioperative blood glucose management in diabetic patients undergoing ambulatory surgery / G. Joshi [et al.] // Anesthesia &amp; Analgesia. - 2010. - Vol. 111, № 6. - P. 1378-1387.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">American Association of Clinical Endocrinologists; American Diabetes Association. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control / E. Moghissi [et al.] // Diabetes Care. - 2009. - Vol. 32, № 6. - P. 1119-1131.</mixed-citation><mixed-citation xml:lang="en">American Association of Clinical Endocrinologists; American Diabetes Association. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control / E. Moghissi [et al.] // Diabetes Care. - 2009. - Vol. 32, № 6. - P. 1119-1131.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Canadian Diabetes Association 2008 Clinical practice guidelines for the prevention and management of diabetes in Canada / L. Berard [et al.] // Canadian Journal of Diabetes. - 2008. - Vol. 32, № 1. - P. 71-76.</mixed-citation><mixed-citation xml:lang="en">Canadian Diabetes Association 2008 Clinical practice guidelines for the prevention and management of diabetes in Canada / L. Berard [et al.] // Canadian Journal of Diabetes. - 2008. - Vol. 32, № 1. - P. 71-76.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Intensive insulin therapy in critically ill patients / G. Van den Berghe [et al.] // The New England Journal of Medicine. - 2001. - Vol. 345, № 19. - P.1359-1367.</mixed-citation><mixed-citation xml:lang="en">Intensive insulin therapy in critically ill patients / G. Van den Berghe [et al.] // The New England Journal of Medicine. - 2001. - Vol. 345, № 19. - P.1359-1367.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Intensive insulin therapy in the medical ICU / G. Van den Berghe [et al.] // The New England Journal of Medicine. - 2006. - Vol. 354, № 5. - P. 449-461.</mixed-citation><mixed-citation xml:lang="en">Intensive insulin therapy in the medical ICU / G. Van den Berghe [et al.] // The New England Journal of Medicine. - 2006. - Vol. 354, № 5. - P. 449-461.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Intensive versus conventional glucose control in critically ill patients / S. Finfer [et al.] // The New England Journal of Medicine. - Vol. 360, № 13. - P. 1283-1297.</mixed-citation><mixed-citation xml:lang="en">Intensive versus conventional glucose control in critically ill patients / S. Finfer [et al.] // The New England Journal of Medicine. - Vol. 360, № 13. - P. 1283-1297.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data / D. Griesdale [et al.] // Canadian Medical Association Journal. - 2009. - Vol. 180, № 8. - P. 821-827.</mixed-citation><mixed-citation xml:lang="en">Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data / D. Griesdale [et al.] // Canadian Medical Association Journal. - 2009. - Vol. 180, № 8. - P. 821-827.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">The effect of tight glycaemic control, during and after cardiac surgery, on patient mortality and morbidity: A systematic review and meta-analysis. / K. Haga [et al.] // Journal of Cardiothoracic Surgery. - 2011. - Vol. 6, № 3. - P. 1-10.</mixed-citation><mixed-citation xml:lang="en">The effect of tight glycaemic control, during and after cardiac surgery, on patient mortality and morbidity: A systematic review and meta-analysis. / K. Haga [et al.] // Journal of Cardiothoracic Surgery. - 2011. - Vol. 6, № 3. - P. 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Misbin, R. I. Phenformin-associated lactic acidosis: pathogenesis and treatment / R. I. Misbin // Annals of Internal Medicine. - 1977. - Vol. 87, № 5. - P. 591-595.</mixed-citation><mixed-citation xml:lang="en">Misbin, R. I. Phenformin-associated lactic acidosis: pathogenesis and treatment / R. I. Misbin // Annals of Internal Medicine. - 1977. - Vol. 87, № 5. - P. 591-595.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Stacpoole, P. W. Metformin and lactic acidosis: guilt by association? / P. W. Stacpoole // Diabetes Care. - 1998. - Vol. 21, № 10. - P. 1587-1588.</mixed-citation><mixed-citation xml:lang="en">Stacpoole, P. W. Metformin and lactic acidosis: guilt by association? / P. W. Stacpoole // Diabetes Care. - 1998. - Vol. 21, № 10. - P. 1587-1588.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis / S. Salpeter [et al.] // Archives of Internal Medicine. - 2003. - Vol. 163, № 21. - P. 2594-2602.</mixed-citation><mixed-citation xml:lang="en">Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis / S. Salpeter [et al.] // Archives of Internal Medicine. - 2003. - Vol. 163, № 21. - P. 2594-2602.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Recent metformin ingestion does not increase in-hospital morbidity or mortality after cardiac surgery / A. Duncan [et al.] // Anesthesia &amp; Analgesia. - 2007. - Vol. 104, № 1. - P. 42-50.</mixed-citation><mixed-citation xml:lang="en">Recent metformin ingestion does not increase in-hospital morbidity or mortality after cardiac surgery / A. Duncan [et al.] // Anesthesia &amp; Analgesia. - 2007. - Vol. 104, № 1. - P. 42-50.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Thinking like a pancreas: perioperative glycemic control / E. Martinez [et al.] // Anesthesia &amp; Analgesia. - 2007. - Vol. 104, № 1. - P. 4-6.</mixed-citation><mixed-citation xml:lang="en">Thinking like a pancreas: perioperative glycemic control / E. Martinez [et al.] // Anesthesia &amp; Analgesia. - 2007. - Vol. 104, № 1. - P. 4-6.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Metformin-induced lactic acidosis: a case series / J. Silvestre [et al.] // Journal of Medical Case Reports. - 2007. - Vol. 1, № 126. - P. 1-4.</mixed-citation><mixed-citation xml:lang="en">Metformin-induced lactic acidosis: a case series / J. Silvestre [et al.] // Journal of Medical Case Reports. - 2007. - Vol. 1, № 126. - P. 1-4.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
