<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2012-9-2-22</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-1264</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНА И БИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERIMENTAL MEDICINE AND BIOLOGY</subject></subj-group></article-categories><title-group><article-title>ЭКСПЕРИМЕНТАЛЬНЫЕ МОДЕЛИ РЕВМАТОИДНОГО АРТРИТА</article-title><trans-title-group xml:lang="en"><trans-title>EXPERIMENTAL MODELS OF RHEUMATOID ARTHRITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Громыко</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gromyko</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грицук</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gritsuk</surname><given-names>A. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Гомельский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Gomel State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2012</year></pub-date><volume>0</volume><issue>2</issue><fpage>115</fpage><lpage>118</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Громыко М.В., Грицук А.И., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Громыко М.В., Грицук А.И.</copyright-holder><copyright-holder xml:lang="en">Gromyko M.V., Gritsuk A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/1264">https://journal.gsmu.by/jour/article/view/1264</self-uri><abstract><p>В обзоре рассматриваются и анализируются наиболее распространенные экспериментальные модели ревматоидного артрита: коллаген-индуцированный, адъювант-индуцированный и пристан-индуцированный.</p></abstract><trans-abstract xml:lang="en"><p>The review covers and analyzes the most common experimental models of rheumatoid arthritis, i.e. adjuvant-induced, collagen-induced and pristane-induced forms.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>адъювант-индуцированный артрит</kwd><kwd>коллаген-индуцированный артрит</kwd><kwd>пристан-индуцированный артрит</kwd><kwd>животные модели РА</kwd><kwd>РА в эксперименте</kwd><kwd>РА у крыс</kwd><kwd>адъювант Фрейнда</kwd><kwd>артрит экспериментальный</kwd><kwd>способы моделирования артрита</kwd><kwd>rheumatoid arthritis</kwd><kwd>adjuvant-induced arthritis</kwd><kwd>collagen-induced arthritis</kwd><kwd>pristane-induced arthritis</kwd><kwd>RA animal models</kwd><kwd>experimental RA</kwd><kwd>RA in rats</kwd><kwd>Freund's adjuvant</kwd><kwd>experimental arthritis</kwd><kwd>arthritis modeling methods</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cuzzocrea, S Characterization of a novel and spontaneous mouse model of infl ammatory arthritis / S. Cuzzocrea // Arthritis Research &amp; Therapy. - 2011. - Vol. 13. - P. 126-129.</mixed-citation><mixed-citation xml:lang="en">Cuzzocrea, S Characterization of a novel and spontaneous mouse model of infl ammatory arthritis / S. Cuzzocrea // Arthritis Research &amp; Therapy. - 2011. - Vol. 13. - P. 126-129.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Type II collagen utoimmunity in animals and provocations leading to arthritis / R. Holmdahl [et al.] // Immunol Rev. - 1990. - Vol. 118. - P. 193-232.</mixed-citation><mixed-citation xml:lang="en">Type II collagen utoimmunity in animals and provocations leading to arthritis / R. Holmdahl [et al.] // Immunol Rev. - 1990. - Vol. 118. - P. 193-232.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Histological, immunological and biochemical studies on type II collagen arthritis in rats / K. Terato [et al.] // Biomed Res. - 1982. - Vol. 3. - P. 495-523.</mixed-citation><mixed-citation xml:lang="en">Histological, immunological and biochemical studies on type II collagen arthritis in rats / K. Terato [et al.] // Biomed Res. - 1982. - Vol. 3. - P. 495-523.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Williams, R Collagen-induced arthritis as a model for rheumatoid arthritis / R. Williams // Methods Mol Med. - 2004. - Vol. 98. - P. 207-216.</mixed-citation><mixed-citation xml:lang="en">Williams, R Collagen-induced arthritis as a model for rheumatoid arthritis / R. Williams // Methods Mol Med. - 2004. - Vol. 98. - P. 207-216.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Animal models of arthritis:relevance to human disease / A. Bendele [et al.] // Toxicologic Pathol. - 1999. - Vol. 27. - P. 134-142.</mixed-citation><mixed-citation xml:lang="en">Animal models of arthritis:relevance to human disease / A. Bendele [et al.] // Toxicologic Pathol. - 1999. - Vol. 27. - P. 134-142.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Бедулева, Л. В. Идиотип-антиидиотипические взаимодействия как механизм развития коллаген-индуцированного артрита у крыс / Л. В. Бедулева, И. В. Меньшиков // Вестник Уральской медицинской академической науки. - 2006. - № 3. - С. 14-17.</mixed-citation><mixed-citation xml:lang="en">Бедулева, Л. В. Идиотип-антиидиотипические взаимодействия как механизм развития коллаген-индуцированного артрита у крыс / Л. В. Бедулева, И. В. Меньшиков // Вестник Уральской медицинской академической науки. - 2006. - № 3. - С. 14-17.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bendele, A. Sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis / A. Bendele // Arthritis Rheum. - 1999. - Vol. 42. - P. 498-506</mixed-citation><mixed-citation xml:lang="en">Bendele, A. Sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis / A. Bendele // Arthritis Rheum. - 1999. - Vol. 42. - P. 498-506</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Waksman, B. Immune regulation in adjuvant disease and other arthritis models: relevance to pathogenesis of chronic arthritis / B. Waksman // Scand J Immunol. - 2002. - Vol. 56. - Р. 12-34.</mixed-citation><mixed-citation xml:lang="en">Waksman, B. Immune regulation in adjuvant disease and other arthritis models: relevance to pathogenesis of chronic arthritis / B. Waksman // Scand J Immunol. - 2002. - Vol. 56. - Р. 12-34.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Suppression and prevention of adjuvant arthritis in rats by a monoclonal antibody to the a/b T cell receptor / S. Yoshino [et al.] // Eur. J. Immunol. - 1990. - Vol. 20. - Р. 2805-2808.</mixed-citation><mixed-citation xml:lang="en">Suppression and prevention of adjuvant arthritis in rats by a monoclonal antibody to the a/b T cell receptor / S. Yoshino [et al.] // Eur. J. Immunol. - 1990. - Vol. 20. - Р. 2805-2808.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Linton, S. Complement activation and inhibition in experimental models of arthritis / S. Linton, B. Morgan // Mol Immunol. - 1999. - Vol. 36. - Р. 905-914.</mixed-citation><mixed-citation xml:lang="en">Linton, S. Complement activation and inhibition in experimental models of arthritis / S. Linton, B. Morgan // Mol Immunol. - 1999. - Vol. 36. - Р. 905-914.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Anti-neutrophil monoclonal antibody therapy inhibits the development of adjuvant arthritis / L. Santos [et al.] // Clin Exp Immunol. - 1997. - Vol. 107. - Р. 248-253.</mixed-citation><mixed-citation xml:lang="en">Anti-neutrophil monoclonal antibody therapy inhibits the development of adjuvant arthritis / L. Santos [et al.] // Clin Exp Immunol. - 1997. - Vol. 107. - Р. 248-253.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Issekutz, T. Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation / T. Issekutz, M. Miyasaka, A. Issekutz. // J Exp Med. - 1996. - Vol. 183. - Р. 2175-2184.</mixed-citation><mixed-citation xml:lang="en">Issekutz, T. Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation / T. Issekutz, M. Miyasaka, A. Issekutz. // J Exp Med. - 1996. - Vol. 183. - Р. 2175-2184.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Cytokine mRNA in the joints and draining lymph nodes of rats with adjuvant arthritis and effects of cyclosporine A / L. Ayer [et al.] // Inflammation. - 2000. - Vol. 24. - Р. 447-461.</mixed-citation><mixed-citation xml:lang="en">Cytokine mRNA in the joints and draining lymph nodes of rats with adjuvant arthritis and effects of cyclosporine A / L. Ayer [et al.] // Inflammation. - 2000. - Vol. 24. - Р. 447-461.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Cytokine expression and synovial pathology in the initiation and spontaneous resolution phases of adjuvant arthritis: interleukin-17 expression is upregulated in early disease / K. Bush [et al.] // Clin. Exp. Immunol. - 2001. - Vol. 123. - Р. 487-495.</mixed-citation><mixed-citation xml:lang="en">Cytokine expression and synovial pathology in the initiation and spontaneous resolution phases of adjuvant arthritis: interleukin-17 expression is upregulated in early disease / K. Bush [et al.] // Clin. Exp. Immunol. - 2001. - Vol. 123. - Р. 487-495.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Anti-interleukin-1 and anti-tumor necrosis factor-a synergistically inhibit adjuvant arthritis in Lewis rats / U. Feige [et al.] // Cell. Mol. Life Sci. - 2000. - Vol. 57. - Р. 1457-1470.</mixed-citation><mixed-citation xml:lang="en">Anti-interleukin-1 and anti-tumor necrosis factor-a synergistically inhibit adjuvant arthritis in Lewis rats / U. Feige [et al.] // Cell. Mol. Life Sci. - 2000. - Vol. 57. - Р. 1457-1470.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis / D. Young [et al.] // Arthritis Rheum. - 2007. - Vol. 56. - Р. 1152-1163.</mixed-citation><mixed-citation xml:lang="en">Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis / D. Young [et al.] // Arthritis Rheum. - 2007. - Vol. 56. - Р. 1152-1163.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein / K. Bush [et al.] // Arthritis Rheum. - 2002. - Vol. 46. - Р. 802-805</mixed-citation><mixed-citation xml:lang="en">Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein / K. Bush [et al.] // Arthritis Rheum. - 2002. - Vol. 46. - Р. 802-805</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Allison, A. An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity / A. Allison, N. Byars // J. Immunol. Methods. - 1986. - Vol. 95. - Р. 157-168.</mixed-citation><mixed-citation xml:lang="en">Allison, A. An adjuvant formulation that selectively elicits the formation of antibodies of protective isotypes and of cell-mediated immunity / A. Allison, N. Byars // J. Immunol. Methods. - 1986. - Vol. 95. - Р. 157-168.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Копьева, Т. Н. Патология ревматоидного артрита / Т. Н. Копьева. - М.: Медицина, 1980. - 208 с.</mixed-citation><mixed-citation xml:lang="en">Копьева, Т. Н. Патология ревматоидного артрита / Т. Н. Копьева. - М.: Медицина, 1980. - 208 с.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Pearson, C. Studies of polyarthritis and other lesions induced in rats by injection of mycobacterial adjuvant / C. Pearson, F. Wood // Arthritis Rheum. - 1959. - Vol. 2. - Р. 440-459.</mixed-citation><mixed-citation xml:lang="en">Pearson, C. Studies of polyarthritis and other lesions induced in rats by injection of mycobacterial adjuvant / C. Pearson, F. Wood // Arthritis Rheum. - 1959. - Vol. 2. - Р. 440-459.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes / C. Vingsbo [et al.] // Am J Pathol. - 1996. - Vol. 149. -Р. 1675-1683.</mixed-citation><mixed-citation xml:lang="en">Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes / C. Vingsbo [et al.] // Am J Pathol. - 1996. - Vol. 149. -Р. 1675-1683.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Bedwell, A. Immunological involvement in the pathogenesis of pristine induced arthritis / A. Bedwell, C. Elson, C. Hinton // Scand J Immunol. - 1987. - Vol. 25. - Р. 393-398.</mixed-citation><mixed-citation xml:lang="en">Bedwell, A. Immunological involvement in the pathogenesis of pristine induced arthritis / A. Bedwell, C. Elson, C. Hinton // Scand J Immunol. - 1987. - Vol. 25. - Р. 393-398.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Pristane induced arthritis. The immunologic and genetic features of an experimental murine model of autoimmune disease / P. Wooley [et al.] // Arthritis Rheum. - 1989. - Vol. 32. - Р. 1022-1030.</mixed-citation><mixed-citation xml:lang="en">Pristane induced arthritis. The immunologic and genetic features of an experimental murine model of autoimmune disease / P. Wooley [et al.] // Arthritis Rheum. - 1989. - Vol. 32. - Р. 1022-1030.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">The role of oil and agalactosyl IgG in the induction of arthritis in rodent models / G. Rook [et al.] // Eur. J. Immunol. - 1991. - Vol. 21. - Р. 1027-1032.</mixed-citation><mixed-citation xml:lang="en">The role of oil and agalactosyl IgG in the induction of arthritis in rodent models / G. Rook [et al.] // Eur. J. Immunol. - 1991. - Vol. 21. - Р. 1027-1032.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Hitsumoto, Y. Relationship between interleukin 6, agalactosyl IgG and pristane-induced arthritis / Y. Hitsumoto, et al. // Autoimmunity.- 1992.- Vol. 11.- Р. 247-254</mixed-citation><mixed-citation xml:lang="en">Hitsumoto, Y. Relationship between interleukin 6, agalactosyl IgG and pristane-induced arthritis / Y. Hitsumoto, et al. // Autoimmunity.- 1992.- Vol. 11.- Р. 247-254</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis / R. Holmdahl [et al.] // Immunol Rev. - 2001. - Vol. 184. - Р. 184-202.</mixed-citation><mixed-citation xml:lang="en">Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis / R. Holmdahl [et al.] // Immunol Rev. - 2001. - Vol. 184. - Р. 184-202.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Increased serum levels of cartilage oligomeric matrix protein in chronic erosive arthritis in rats / C. Vingsbo-Lundberg [et al.] // Arthritis Rheum. - 1998. - Vol. 41. - Р. 544-550.</mixed-citation><mixed-citation xml:lang="en">Increased serum levels of cartilage oligomeric matrix protein in chronic erosive arthritis in rats / C. Vingsbo-Lundberg [et al.] // Arthritis Rheum. - 1998. - Vol. 41. - Р. 544-550.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
