zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2012-9-2-14zdor-1256Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEПАПИЛЛОМАВИРУСНАЯ И СОПУТСТВУЮЩАЯ ИНФЕКЦИЯ ГЕНИТАЛИЙ У БЕРЕМЕННЫХ С ВИЧ-ОТРИЦАТЕЛЬНЫМ И ВИЧ-ПОЛОЖИТЕЛЬНЫМ СТАТУСОМPAPILLOMAVIRUS AND GENITAL CO-INFECTIONS IN PREGNANT HIV-NEGATIVE AND HIV-POSITIVE WOMENКустоваМ. А.KustovaM. A.noemail@neicon.ruГомельский государственный медицинский университетGomel State Medical University201228062012027784Copyright © Кустова М.А., 20122012Кустова М.А.Kustova M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/1256

Цель: изучить особенности папилломавирусной инфекции в сочетании с сопутствующими инфекциями урогенитального тракта у ВИЧ-инфицированных и ВИЧ-неинфицированных беременных. Материал и методы. Объект исследования - 144 беременные, обследованные на присутствие ДНК вируса папилломы человека и герпесвирусов в соскобах шейки матки. Обследование на хламидийную инфекцию проведено иммуноферментным анализом, на уреаплазменную инфекцию гениталий - культуральным методом, диагностика генитального кандидоза осуществлялась методом микроскопии. Результаты. Изучены особенности папилломавирусной инфекции в сочетании с урогенитальным хламидиозом, уреаплазмозом, кандидозом, инфицированием герпесвирусами у ВИЧ-инфицированных и ВИЧ-неинфицированных беременных. Заключение. Наиболее частой сопутствующей инфекцией гениталий при ПВИ у беременных является вульвовагинальный кандидоз, встречающийся в 37,5 ± 4,9 % случаев. ВИЧ-позитивные беременные имеют сопутствующие генитальные инфекции в 79,1 ± 6,2 % случаев, что значимо чаще в сравнении с ВИЧ-негативными беременными (56,4 ± 4,9 %). У ВПЧ-инфицированных беременных при отсутствии маркеров хламидийной инфекции и генитального кандидоза значимо реже наблюдается наличие дисплазии шейки матки в сочетании с генитальным папилломатозом (7,5 ± 4,2 и 4,7 ± 3,2 % соответственно), обратная тенденция отмечается при инфицировании U. urealyticum - дисплазия шейки матки с папилломами гениталий встречается в 43,8 ± 12,8 % случаев.

Objective: to study the features of human papillomavirus (HPV) infection, combined with the co-infections of the urogenital tract in HIV-positive and HIV-negative pregnant women. Material and methods. The object of the study was 144 pregnant women examined for the presence of HPV DNA and herpes viruses in cervical scrapes. The screening for chlamydial infection was conducted by ELISA method, the culture method was used to detect genital ureaplasma infection, the diagnosis of genital candidiasis was carried out by microscopy. Results. The features of HPV infection were studied in the combination with urogenital chlamydiosis, ureaplasmosis, candidiasis, herpes infection in the HIV-positive and HIV-negative pregnant women. Conclusion. Vulvovaginal candidiasis is the most prevalent concomitant genital infection in the HPV-positive pregnant women (37,5 ± 4,9 % of cases). The HIV-positive pregnant women have concomitant genital infections (79,1 ± 6,2 %) oftener then the HIV-negative pregnant women (56,4 ± 4,9 %). The HPV-infected pregnant women with no markers of chlamydial infection and genital candidiasis reveal cervical dysplasia in combination with genital papillomatosis less often (7,5 ± 4,2 and 4,7 ± 3,2 %, respectively). Thus, there is a reverse tendency in case of U. urealyticum infection, as 43,8 ± 12,8 % of the pregnant women with ureaplasma injection observe cervical dysplasia with genital pappilomas.

вирус папилломы человекабеременностьгенитальные инфекцииhuman papillomaviruspregnancygenital infectionsReferencesAl-Daraji, W. I. Infection and Cervical Neoplasia: Facts and Fiction / W. I. Al-Daraji, J. H. F. Smith // Int J Clin Exp Pathol. - 2009. - Vol. 2(1). - P. 48-64.Al-Daraji, W. I. Infection and Cervical Neoplasia: Facts and Fiction / W. I. Al-Daraji, J. H. F. Smith // Int J Clin Exp Pathol. - 2009. - Vol. 2(1). - P. 48-64.Кулага, О. К. Ассоциированные урогенитальные инфекции в акушерстве и гинекологии: современный взгляд на проблему / О. К. Кулага, С. А. Костюк. - Минск, 2008.Кулага, О. К. Ассоциированные урогенитальные инфекции в акушерстве и гинекологии: современный взгляд на проблему / О. К. Кулага, С. А. Костюк. - Минск, 2008.Бурьяк, Д. В. Поэтапное лечение генитальной папилломавирусной инфекции / Д. В. Бурьяк // Здравоохранение. - 2008. - № 9. - С. 54-57.Бурьяк, Д. В. Поэтапное лечение генитальной папилломавирусной инфекции / Д. В. Бурьяк // Здравоохранение. - 2008. - № 9. - С. 54-57.Human Papillomaviruses and genital co-infections in gynaecological outpatients / R. Verteramo [et al.] // BMC Infect Dis. - 2009. - Vol. 9. - P. 16.Human Papillomaviruses and genital co-infections in gynaecological outpatients / R. Verteramo [et al.] // BMC Infect Dis. - 2009. - Vol. 9. - P. 16.Association of human papillomavirus infection with other microbial pathogens in gynecology / M. Y. Zheng [et al.] // Zhonghua Fu Chan Ke Za Zhi. - 2010. - Vol. 45(6). - P. 424-428.Association of human papillomavirus infection with other microbial pathogens in gynecology / M. Y. Zheng [et al.] // Zhonghua Fu Chan Ke Za Zhi. - 2010. - Vol. 45(6). - P. 424-428.Co-expression of HSV2 and Chlamydia trachomatis in HPV-positive cervical cancer and cervical intraepithelial neoplasia lesions is associated with aberrations in key intracellular pathways / P. Paba [et al.] // Intervirology. - 2008. - Vol. 51(4). - P. 230-234.Co-expression of HSV2 and Chlamydia trachomatis in HPV-positive cervical cancer and cervical intraepithelial neoplasia lesions is associated with aberrations in key intracellular pathways / P. Paba [et al.] // Intervirology. - 2008. - Vol. 51(4). - P. 230-234.Increased frequency of bacterial vaginosis and Chlamydia trachomatis in pregnant women with human papillomavirus infection/ CS da Silva [et al.] // Gynecol Obstet Invest. - 2004. - Vol. 58(4). - P. 189-193.Increased frequency of bacterial vaginosis and Chlamydia trachomatis in pregnant women with human papillomavirus infection/ CS da Silva [et al.] // Gynecol Obstet Invest. - 2004. - Vol. 58(4). - P. 189-193.Chlamydia trachomatis as a probable cofactor in human papillomavirus infection in aboriginal women from northeastern Argentina/ G. D. Deluca [et al.] // Braz J Infect Dis. - 2011. - Vol. 15(6). - P. 567-572.Chlamydia trachomatis as a probable cofactor in human papillomavirus infection in aboriginal women from northeastern Argentina/ G. D. Deluca [et al.] // Braz J Infect Dis. - 2011. - Vol. 15(6). - P. 567-572.Chlamydia trachomatis and papillomavirus infection in women with cytohistological abnormalities in uterine cervix / G. D. Deluca [et al.] // Medicina (B Aires). - 2006. - Vol. 66(4). - P. 303-306.Chlamydia trachomatis and papillomavirus infection in women with cytohistological abnormalities in uterine cervix / G. D. Deluca [et al.] // Medicina (B Aires). - 2006. - Vol. 66(4). - P. 303-306.Chlamydia trachomatis and invasive cervical cancer: a pooled analysis of the IARC multicentric case-control study / J. S. Smith [et al.] // Int J Cancer. - 2004. - Vol. 111(3). - P. 431-439.Chlamydia trachomatis and invasive cervical cancer: a pooled analysis of the IARC multicentric case-control study / J. S. Smith [et al.] // Int J Cancer. - 2004. - Vol. 111(3). - P. 431-439.Seroprevalence of human papillomaviruses and Chlamydia trachomatis and cervical cancer risk: nested case-control study / P Naucler [et al.] // J. Gen. Virol. - 2007. - Vol. 88(3). - P. 814-822.Seroprevalence of human papillomaviruses and Chlamydia trachomatis and cervical cancer risk: nested case-control study / P Naucler [et al.] // J. Gen. Virol. - 2007. - Vol. 88(3). - P. 814-822.Comprehensive analysis of Human Papillomavirus and Chlamydia trachomatis in in-situ and invasive cervical adenocarcinoma / K. D. Qint [et al.] // Gynaecol Oncol. - 2009. - Vol. 114(3). - P. 390-394.Comprehensive analysis of Human Papillomavirus and Chlamydia trachomatis in in-situ and invasive cervical adenocarcinoma / K. D. Qint [et al.] // Gynaecol Oncol. - 2009. - Vol. 114(3). - P. 390-394.Prevalence of Chlamydia trachomatis and herpes simplex virus 2 in cervical carcinoma associated with human papillomavirus detected in paraffin-sectioned samples / A Kwasniewska [et al.] // Eur. J. Gynaecol. Oncol. - 2009. - Vol. 30(1). - P. 65-70.Prevalence of Chlamydia trachomatis and herpes simplex virus 2 in cervical carcinoma associated with human papillomavirus detected in paraffin-sectioned samples / A Kwasniewska [et al.] // Eur. J. Gynaecol. Oncol. - 2009. - Vol. 30(1). - P. 65-70.Detection of Chlamydia trachomatis and herpes simplex virus type 1 or 2 in cervical samples in human papilloma virus (HPV)-positive and HPV-negative women / R. R. Finan [et al.] // Clin. Microbiol. Infect. - 2006. - Vol. 12(9). - P. 927-930.Detection of Chlamydia trachomatis and herpes simplex virus type 1 or 2 in cervical samples in human papilloma virus (HPV)-positive and HPV-negative women / R. R. Finan [et al.] // Clin. Microbiol. Infect. - 2006. - Vol. 12(9). - P. 927-930.Detection of sexually transmitted infection and human papillomavirus in negative cytology by multiplex-PCR/ H-S Shim [et al.] // BMC Infect Dis. - 2010. - Vol. 10. - P. 284.Detection of sexually transmitted infection and human papillomavirus in negative cytology by multiplex-PCR/ H-S Shim [et al.] // BMC Infect Dis. - 2010. - Vol. 10. - P. 284.Feher, E. Prevalence of Chlamydia trachomatis and oncogenic human papillomavirus types in cytologic atypia of the uterine cervix / E. Feher, A. Szalmas // Acta Microbiol Immunol Hung. - 2006. - Vol. 53(4). - P. 479-487.Feher, E. Prevalence of Chlamydia trachomatis and oncogenic human papillomavirus types in cytologic atypia of the uterine cervix / E. Feher, A. Szalmas // Acta Microbiol Immunol Hung. - 2006. - Vol. 53(4). - P. 479-487.Chlamydia trachomatis and Risk of Prevalent and Incident Cervical Premalignancy in a Population-Based Cohort / M. Safaeian [et al.] // J. Natl. Cancer. Inst. - 2010. - Vol. 102(23). - P. 1794-1804.Chlamydia trachomatis and Risk of Prevalent and Incident Cervical Premalignancy in a Population-Based Cohort / M. Safaeian [et al.] // J. Natl. Cancer. Inst. - 2010. - Vol. 102(23). - P. 1794-1804.Study on the relationship between genesis and development of cervical cancer and the infection of human papillomavirus type 16/18, human herpesvirus II and cytomegalovirus / Y. S. Qian [et al.] // Zhonghua Liu Xing Bing Xue Za Zhi. - 2005. - Vol. 26(8). - P. 622-625.Study on the relationship between genesis and development of cervical cancer and the infection of human papillomavirus type 16/18, human herpesvirus II and cytomegalovirus / Y. S. Qian [et al.] // Zhonghua Liu Xing Bing Xue Za Zhi. - 2005. - Vol. 26(8). - P. 622-625.Herpesviruses as possible cofactors in HPV-16-related oncogenesis / S. Szostek [et al.] // Acta Biochim Pol. - 2009. - Vol. 56(2). - P. 337-342.Herpesviruses as possible cofactors in HPV-16-related oncogenesis / S. Szostek [et al.] // Acta Biochim Pol. - 2009. - Vol. 56(2). - P. 337-342.Is the presence of herpesviruses in cervical secretions a prognostic factor for cervical pathology in HPV-positive women / S. Szostek [et al.] // Przegl Epidemiol. - 2009. - Vol. 63(1). - P. 97-101.Is the presence of herpesviruses in cervical secretions a prognostic factor for cervical pathology in HPV-positive women / S. Szostek [et al.] // Przegl Epidemiol. - 2009. - Vol. 63(1). - P. 97-101.Concomitant infections with human papillomavirus and various mycoplasma and ureaplasma species in women with abnormal cervical cytology / M. Biernat-Sudolska [et al.] // Adv Med Sci. - 2011. - Vol. 56(2). - P. 299-303.Concomitant infections with human papillomavirus and various mycoplasma and ureaplasma species in women with abnormal cervical cytology / M. Biernat-Sudolska [et al.] // Adv Med Sci. - 2011. - Vol. 56(2). - P. 299-303.May ureaplasmas in genital tract of HPV-positive women influence abnormal cytology of cervix / M. Biernat-Sudolska [et al.] // Przegl Epidemiol. / 2008 - V. 62(2). - P. 447-52.May ureaplasmas in genital tract of HPV-positive women influence abnormal cytology of cervix / M. Biernat-Sudolska [et al.] // Przegl Epidemiol. / 2008 - V. 62(2). - P. 447-52.Determination of cervicovaginal microorganisms in women with abnormal cervical cytology: the role of Ureaplasma urealyticum / A. Lukic [et al.] // Anticancer Res. - 2006. - Vol. 26(6C). - P. 4843-4849.Determination of cervicovaginal microorganisms in women with abnormal cervical cytology: the role of Ureaplasma urealyticum / A. Lukic [et al.] // Anticancer Res. - 2006. - Vol. 26(6C). - P. 4843-4849.Hall, J. High risk human papillomavirus DNA detection in pap tests with both atypical squamous cells of undetermined significance and Candida / J. Hall, B. Kendall // Acta Cytol. - 2009. - Vol. 53(2). - P. 150-152.Hall, J. High risk human papillomavirus DNA detection in pap tests with both atypical squamous cells of undetermined significance and Candida / J. Hall, B. Kendall // Acta Cytol. - 2009. - Vol. 53(2). - P. 150-152.

The authors declare that there are no conflicts of interest present.