zdorПроблемы здоровья и экологииHealth and Ecology Issues2220-09672708-6011Gomel State Medical University10.51523/2708-6011.2011-8-2s-30zdor-1206Research ArticleБез разделаЭФФЕКТИВНОСТЬ ЛЕЧЕНИЯ ОСТРОГО МИЕЛОБЛАСТНОГО ЛЕЙКОЗА С ИСПОЛЬЗОВАНИЕМ ПРОТОКОЛА FLAGFLAG PROTOCOL-BASED CURE RATE OF ACUTE MYELOID LEUKEMIAТретякН. Н.TretyakN. N.noemail@neicon.ruГоряиноваН. В.GoryainovaN. V.noemail@neicon.ruКиселеваЕ. А.KiseliovaE. A.noemail@neicon.ruКовальА. И.KovalA. I.noemail@neicon.ruАношинаМ. Ю.AnoshinaM. Yu.noemail@neicon.ruБасоваО. В.BasovaO. V.noemail@neicon.ruВакульчукА. М.VakulchukA. M.noemail@neicon.ruПерехрестенкоТ. П.PerehrestenkoT. P.noemail@neicon.ruМнишенкоВ. Н.MnishenkoV. N.noemail@neicon.ruИнститут гематологии и трансфузиологии АМН УкраиныInstitute of Haematology and Transfusiology AMS Ukraine20112812201102S8587Copyright © Третяк Н.Н., Горяинова Н.В., Киселева Е.А., Коваль А.И., Аношина М.Ю., Басова О.В., Вакульчук А.М., Перехрестенко Т.П., Мнишенко В.Н., 20112011Третяк Н.Н., Горяинова Н.В., Киселева Е.А., Коваль А.И., Аношина М.Ю., Басова О.В., Вакульчук А.М., Перехрестенко Т.П., Мнишенко В.Н.Tretyak N.N., Goryainova N.V., Kiseliova E.A., Koval A.I., Anoshina M.Y., Basova O.V., Vakulchuk A.M., Perehrestenko T.P., Mnishenko V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.gsmu.by/jour/article/view/1206

В статье представлены собственные результаты лечения 54 пациентов с впервые выявленными и резистентными формами острого миелобластного лейкоза (ОМЛ) с использованием флударабинсодержащего протокола FLAG. Показано, что применение указанной схемы химиотерапии является высокоэффективным и позволяет добиться ремиссии у большинства пациентов.

The article presents the results of our own fludarabin-containing FLAG protocol-based treatment of 54 patients with both first detected and resistant forms of acute myeloid leukemia. It has been shown that, the application of the indicated chemiotherapy scheme is highly effective and makes it possible to assure remission in most patients.

острый миелобластный лейкозлечениеэффективностьacute myeloid leukemiatreatmentcure rateReferencesБИБЛИОГРАФИЧЕСКИЙ СПИСОКБИБЛИОГРАФИЧЕСКИЙ СПИСОКPharmacokinetics and pharmacodynamics studies of fludarabine and cytosine arabinoside administered as loading boluses followed by continuous infusion / V. I. Avramis [et al.] // The Children Cancer Group. Clin. Cancer Res. - 1998. - Vol. 4(1). - P. 45-52.Pharmacokinetics and pharmacodynamics studies of fludarabine and cytosine arabinoside administered as loading boluses followed by continuous infusion / V. I. Avramis [et al.] // The Children Cancer Group. Clin. Cancer Res. - 1998. - Vol. 4(1). - P. 45-52.Cortes, J. E. Defining the optimal dose schedule of purine analogs and assessment of response / J. E. Cortes, S. M. O’Brien; ed.: B. D. Cheson [et al.]. // Nucleoside analogs in cancer therapy. - New York: Marcel. Dekker. Inc. - 1997. - P. 175-200.Cortes, J. E. Defining the optimal dose schedule of purine analogs and assessment of response / J. E. Cortes, S. M. O’Brien; ed.: B. D. Cheson [et al.]. // Nucleoside analogs in cancer therapy. - New York: Marcel. Dekker. Inc. - 1997. - P. 175-200.Gandhi, V. Cellular and clinical pharmacology of fludarabine / V. Gandhi, W. Plunkett // Clin. Pharmacokinet. - 2002. - Vol. 41. - P. 93-103.Gandhi, V. Cellular and clinical pharmacology of fludarabine / V. Gandhi, W. Plunkett // Clin. Pharmacokinet. - 2002. - Vol. 41. - P. 93-103.Combination of fludarabine and arabinosylcytosine for the treatment of chronic lymphocytic leukemia: clinical efficacy and modulation of arabinosylcytosine pharmacology / V. Gandhi [et al.] // Cancer Chem. Pharmacol. - 1994. - Vol. 34. - P. 30-36.Combination of fludarabine and arabinosylcytosine for the treatment of chronic lymphocytic leukemia: clinical efficacy and modulation of arabinosylcytosine pharmacology / V. Gandhi [et al.] // Cancer Chem. Pharmacol. - 1994. - Vol. 34. - P. 30-36.Grant, S. Ara-C: cellular and molecular pharmacology / S. Grant // Adv. Cancer Res. - 1998. - Vol. 72. - P. 197-233.Grant, S. Ara-C: cellular and molecular pharmacology / S. Grant // Adv. Cancer Res. - 1998. - Vol. 72. - P. 197-233.Fludarabine in low-grade lymphoma / A. Pigaditou [et al.] // Semin. Oncol. - 1993. - Vol. 20, № 7. - P. 24-27.Fludarabine in low-grade lymphoma / A. Pigaditou [et al.] // Semin. Oncol. - 1993. - Vol. 20, № 7. - P. 24-27.Plunkett, W. Metabolism and action of fludarabine phosphate / W. Plunkett, P. Huang, V. Gandhi // Semin. Oncol. - 1990. - Vol. 17, № 8. - Р. 3-17.Plunkett, W. Metabolism and action of fludarabine phosphate / W. Plunkett, P. Huang, V. Gandhi // Semin. Oncol. - 1990. - Vol. 17, № 8. - Р. 3-17.Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-D-arabinosyl-2-fluoroadenine / L. E. Robertson [et al.] // Blood. - 1993. - Vol. 81. - P. 143-150.Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-D-arabinosyl-2-fluoroadenine / L. E. Robertson [et al.] // Blood. - 1993. - Vol. 81. - P. 143-150.Fludarabine plus doxorubicin in previously treated chronic lymphocytic leukemia / L. E. Robertson [et al.] // Leukemia. - 1995. - Vol. 9. - P. 943-945.Fludarabine plus doxorubicin in previously treated chronic lymphocytic leukemia / L. E. Robertson [et al.] // Leukemia. - 1995. - Vol. 9. - P. 943-945.Fludarabine and epirubicin in the treatment of chronic lymphocytic leukaemia: а German multicenter phase II study / M. J. Rummel [et al.] // Ann. Oncol. - 1999. - Vol. 10. - P. 183-188.Fludarabine and epirubicin in the treatment of chronic lymphocytic leukaemia: а German multicenter phase II study / M. J. Rummel [et al.] // Ann. Oncol. - 1999. - Vol. 10. - P. 183-188.

The authors declare that there are no conflicts of interest present.