<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2011-8-3-26</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-1143</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНАЯ МЕДИЦИНА И БИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERIMENTAL MEDICINE AND BIOLOGY</subject></subj-group></article-categories><title-group><article-title>МЕЛАТОНИН: МЕДИКО-БИОЛОГИЧЕСКИЕ ФУНКЦИИ</article-title><trans-title-group xml:lang="en"><trans-title>MELATONINE: MEDICAL AND BIOLOGICAL FUNCTIONS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наумов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Naumov</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Конюх</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Konyuh</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Гродненский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Grodno State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2011</year></pub-date><volume>0</volume><issue>3</issue><fpage>132</fpage><lpage>136</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Наумов А.В., Конюх Е.А., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Наумов А.В., Конюх Е.А.</copyright-holder><copyright-holder xml:lang="en">Naumov A.V., Konyuh E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/1143">https://journal.gsmu.by/jour/article/view/1143</self-uri><abstract><p>В обзоре литературы рассматривается физиологическая роль мелатонина, механизмы его синтеза и катаболизма, а также медицинские аспекты его применения на основании экспериментальных и клинических исследований.</p></abstract><trans-abstract xml:lang="en"><p>The literature review gives consideration to the physiological role of melatonin, mechanisms of its synthesis and catabolism and also the medical aspects of its application on the basis of experimental and clinical research.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мелатонин</kwd><kwd>синтез</kwd><kwd>катаболизм</kwd><kwd>функции</kwd><kwd>melatonin</kwd><kwd>synthesis</kwd><kwd>catabolism</kwd><kwd>functions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zimecki, M. The lunar cycle: effects on human and animal behavior and physiology / M. Zimecki // Postepy Hig. Med. Dosw. (Online). - 2006. - № 60. - P. 1-7.</mixed-citation><mixed-citation xml:lang="en">Zimecki, M. The lunar cycle: effects on human and animal behavior and physiology / M. Zimecki // Postepy Hig. Med. Dosw. (Online). - 2006. - № 60. - P. 1-7.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin / D. X. Tan [et al.] // J. Pineal. Res. - 2003. - Vol. 34, № 1. - P. 75-78.</mixed-citation><mixed-citation xml:lang="en">Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin / D. X. Tan [et al.] // J. Pineal. Res. - 2003. - Vol. 34, № 1. - P. 75-78.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Maestroni, G. J. The immunotherapeutic potential of melatonin / G. J. Maestroni // Expert. Opin. Investig. Drugs. - 2001. - Vol. 10, № 3. - P. 467-476.</mixed-citation><mixed-citation xml:lang="en">Maestroni, G. J. The immunotherapeutic potential of melatonin / G. J. Maestroni // Expert. Opin. Investig. Drugs. - 2001. - Vol. 10, № 3. - P. 467-476.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Melatonin cytotoxicity in human leukemia cells: relation with its pro-oxidant effect / M. Büyükavci [et al.] // Fundam. Clin. Pharmacol. - 2006. - Vol. 20, № 1. - P. 73-79.</mixed-citation><mixed-citation xml:lang="en">Melatonin cytotoxicity in human leukemia cells: relation with its pro-oxidant effect / M. Büyükavci [et al.] // Fundam. Clin. Pharmacol. - 2006. - Vol. 20, № 1. - P. 73-79.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Urinary 6-sulfatoxymelatonin levels and their correlations with lifestyle factors and steroid hormone levels / E. S. Schernhammer [et al.] // J. Pineal. Res. - 2006. - Vol. 40, № 2. - P. 116-124.</mixed-citation><mixed-citation xml:lang="en">Urinary 6-sulfatoxymelatonin levels and their correlations with lifestyle factors and steroid hormone levels / E. S. Schernhammer [et al.] // J. Pineal. Res. - 2006. - Vol. 40, № 2. - P. 116-124.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lee, C. O. Complementary and alternative medicines patients are talking about: melatonin / C. O. Lee // Clin. J. Oncol. Nurs. - 2006. - Vol. 10, № 1. - P. 105-107.</mixed-citation><mixed-citation xml:lang="en">Lee, C. O. Complementary and alternative medicines patients are talking about: melatonin / C. O. Lee // Clin. J. Oncol. Nurs. - 2006. - Vol. 10, № 1. - P. 105-107.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Effects of maternal deprivation on melatonin production and cognition in adolescent male and female rats / N. Uysal [et al.] // Neuro Endocrinol. Lett. - 2005. - Vol. 26, № 5. - P. 555-560.</mixed-citation><mixed-citation xml:lang="en">Effects of maternal deprivation on melatonin production and cognition in adolescent male and female rats / N. Uysal [et al.] // Neuro Endocrinol. Lett. - 2005. - Vol. 26, № 5. - P. 555-560.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Melatonin in Chinese medicinal herbs / G. Chen [et al.] // Life Sci. - 2003. - Vol. 73, № 1. - P. 19-26.</mixed-citation><mixed-citation xml:lang="en">Melatonin in Chinese medicinal herbs / G. Chen [et al.] // Life Sci. - 2003. - Vol. 73, № 1. - P. 19-26.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report / D. W. Spence [et al.] // J. Neuropsychiatry Clin. Neurosci. - 2004. - Vol. 16, № 1. - P. 19-28.</mixed-citation><mixed-citation xml:lang="en">Acupuncture increases nocturnal melatonin secretion and reduces insomnia and anxiety: a preliminary report / D. W. Spence [et al.] // J. Neuropsychiatry Clin. Neurosci. - 2004. - Vol. 16, № 1. - P. 19-28.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis / C. Chojnacki [et al.] // J. Physiol. Pharmacol. - 2011. - Vol. 62, № 3. - P. 327-334.</mixed-citation><mixed-citation xml:lang="en">Evaluation of melatonin effectiveness in the adjuvant treatment of ulcerative colitis / C. Chojnacki [et al.] // J. Physiol. Pharmacol. - 2011. - Vol. 62, № 3. - P. 327-334.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Short- and long-term effects of melatonin on myocardial post-ischemic recovery / A. Lochner [et al.] // J. Pineal. Res. - 2006. - Vol. 40, № 1. - P. 56-63.</mixed-citation><mixed-citation xml:lang="en">Short- and long-term effects of melatonin on myocardial post-ischemic recovery / A. Lochner [et al.] // J. Pineal. Res. - 2006. - Vol. 40, № 1. - P. 56-63.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Melatonin reduces urinary excretion of N-acetyl-beta-D-glucosaminidase, albumin and renal oxidative markers in diabetic rats / F. Oktem [et al.] // Clin. Exp. Pharmacol. Physiol. - 2006. - Vol. 33, № 1-2. - P. 95-101.</mixed-citation><mixed-citation xml:lang="en">Melatonin reduces urinary excretion of N-acetyl-beta-D-glucosaminidase, albumin and renal oxidative markers in diabetic rats / F. Oktem [et al.] // Clin. Exp. Pharmacol. Physiol. - 2006. - Vol. 33, № 1-2. - P. 95-101.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mechanisms regulating the marked seasonal variation in melatonin synthesis in the European hamster pineal gland / M. L. Garidou [et al.] // Am. J. Physiol. Regul. Integr. Comp. Physiol. - 2003. - Vol. 284, № 4. - P. 1043-1052.</mixed-citation><mixed-citation xml:lang="en">Mechanisms regulating the marked seasonal variation in melatonin synthesis in the European hamster pineal gland / M. L. Garidou [et al.] // Am. J. Physiol. Regul. Integr. Comp. Physiol. - 2003. - Vol. 284, № 4. - P. 1043-1052.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ribelayga, C. HIOMT drives the photoperiodic changes in the amplitude of the melatonin peak of the Siberian hamster / C. Ribelayga, P. Pévet, V. Simonneaux // Am. J. Physiol. Regul. Integr. Comp. Physiol. - 2000. - Vol. 278, № 5. - P. 1339-1345.</mixed-citation><mixed-citation xml:lang="en">Ribelayga, C. HIOMT drives the photoperiodic changes in the amplitude of the melatonin peak of the Siberian hamster / C. Ribelayga, P. Pévet, V. Simonneaux // Am. J. Physiol. Regul. Integr. Comp. Physiol. - 2000. - Vol. 278, № 5. - P. 1339-1345.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Photoneural regulation of rat pineal hydroxyindole-O-methyltransferase (HIOMT) messenger ribonucleic acid expression: an analysis of its complex relationship with HIOMT activity / C. Ribelayga [et al.] // Endocrinology. - 1999. - Vol. 140, № 3. - P. 1375-1384.</mixed-citation><mixed-citation xml:lang="en">Photoneural regulation of rat pineal hydroxyindole-O-methyltransferase (HIOMT) messenger ribonucleic acid expression: an analysis of its complex relationship with HIOMT activity / C. Ribelayga [et al.] // Endocrinology. - 1999. - Vol. 140, № 3. - P. 1375-1384.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Modulation of pancreatic enzyme secretion by melatonin and its precursor; L-tryptophan. Role of CCK and afferent nerves / A. Leja-Szpak [et al.] // J. Physiol. Pharmacol. - 2004. - Vol. 55, № 2. - P. 33-46.</mixed-citation><mixed-citation xml:lang="en">Modulation of pancreatic enzyme secretion by melatonin and its precursor; L-tryptophan. Role of CCK and afferent nerves / A. Leja-Szpak [et al.] // J. Physiol. Pharmacol. - 2004. - Vol. 55, № 2. - P. 33-46.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Effects of melatonin in perimenopausal and menopausal women: our personal experience / G. Bellipanni [et al.] // Ann. N. Y. Acad. Sci. - 2005. - Vol. 1057. - P. 393-402.</mixed-citation><mixed-citation xml:lang="en">Effects of melatonin in perimenopausal and menopausal women: our personal experience / G. Bellipanni [et al.] // Ann. N. Y. Acad. Sci. - 2005. - Vol. 1057. - P. 393-402.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hriscu, M. L. Modulatory factors of circadian phagocytic activity / M. L. Hriscu // Ann. N. Y. Acad. Sci. - 2005. - № 1057. - P. 403-430.</mixed-citation><mixed-citation xml:lang="en">Hriscu, M. L. Modulatory factors of circadian phagocytic activity / M. L. Hriscu // Ann. N. Y. Acad. Sci. - 2005. - № 1057. - P. 403-430.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Baydas, G. Comparison of the impact of melatonin on chronic ethanol-induced learning and memory impairment between young and aged rats / G. Baydas, A. Yasar, M. Tuzcu // J. Pineal. Res. - 2005. - Vol. 39, № 4. - P. 346-352.</mixed-citation><mixed-citation xml:lang="en">Baydas, G. Comparison of the impact of melatonin on chronic ethanol-induced learning and memory impairment between young and aged rats / G. Baydas, A. Yasar, M. Tuzcu // J. Pineal. Res. - 2005. - Vol. 39, № 4. - P. 346-352.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Therapeutic actions of melatonin in cancer: possible mechanisms / V. Srinivasan [et al.] // Integr. Cancer. Ther. - 2008. - Vol. 7, № 3. - P. 189-203.</mixed-citation><mixed-citation xml:lang="en">Therapeutic actions of melatonin in cancer: possible mechanisms / V. Srinivasan [et al.] // Integr. Cancer. Ther. - 2008. - Vol. 7, № 3. - P. 189-203.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Inhibitory effects of melatonin on the growth of pituitary prolactin-secreting tumor in rats / Q. H. Yang [et al.] // J. Pineal. Res. - 2006. - Vol. 40, № 3. - P. 230-235.</mixed-citation><mixed-citation xml:lang="en">Inhibitory effects of melatonin on the growth of pituitary prolactin-secreting tumor in rats / Q. H. Yang [et al.] // J. Pineal. Res. - 2006. - Vol. 40, № 3. - P. 230-235.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Johe, P. D. The in vivo effect of melatonin on cellular activation processes in human blood during strenuous physical exercise / P. D. Johe, B. Østerud // J. Pineal. Res. - 2005. - Vol. 39, № 3. - P. 324-330.</mixed-citation><mixed-citation xml:lang="en">Johe, P. D. The in vivo effect of melatonin on cellular activation processes in human blood during strenuous physical exercise / P. D. Johe, B. Østerud // J. Pineal. Res. - 2005. - Vol. 39, № 3. - P. 324-330.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Melatonin prevents hyperhomocysteinemia and neural lipid peroxidation induced by methionine intake / M. Bouzouf [et al.] // Curr. Neurovasc. Res. - 2005. - Vol. 2, № 2. - P. 175-178.</mixed-citation><mixed-citation xml:lang="en">Melatonin prevents hyperhomocysteinemia and neural lipid peroxidation induced by methionine intake / M. Bouzouf [et al.] // Curr. Neurovasc. Res. - 2005. - Vol. 2, № 2. - P. 175-178.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro / Q. Mei [et al.] // Postgrad. Med. J. - 2005. - Vol. 81, № 960. - P. 667-672.</mixed-citation><mixed-citation xml:lang="en">Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro / Q. Mei [et al.] // Postgrad. Med. J. - 2005. - Vol. 81, № 960. - P. 667-672.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Betancourt-Fursow de Jiménez, Y.M. Attention deficit hyperactivity disorder and sleep disorders / Y. M. Betancourt-Fursow de Jiménez, J. C. Jiménez-León, C. S. Jiménez-Betancourt // Rev. Neurol. - 2006. - Vol. 42, № 2. - P. 37-51.</mixed-citation><mixed-citation xml:lang="en">Betancourt-Fursow de Jiménez, Y.M. Attention deficit hyperactivity disorder and sleep disorders / Y. M. Betancourt-Fursow de Jiménez, J. C. Jiménez-León, C. S. Jiménez-Betancourt // Rev. Neurol. - 2006. - Vol. 42, № 2. - P. 37-51.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Sutherland, E. R. Nocturnal asthma / E. R. Sutherland // J. Allergy Clin. Immunol. - 2005. - Vol. 116, № 6. - P. 1179-1186.</mixed-citation><mixed-citation xml:lang="en">Sutherland, E. R. Nocturnal asthma / E. R. Sutherland // J. Allergy Clin. Immunol. - 2005. - Vol. 116, № 6. - P. 1179-1186.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Grandgirard, D. Strategies to prevent neuronal damage in paediatric bacterial meningitis / D. Grandgirard, S. L. Leib // Curr. Opin. Pediatr. - 2006. - Vol. 18, № 2. - P. 112-118.</mixed-citation><mixed-citation xml:lang="en">Grandgirard, D. Strategies to prevent neuronal damage in paediatric bacterial meningitis / D. Grandgirard, S. L. Leib // Curr. Opin. Pediatr. - 2006. - Vol. 18, № 2. - P. 112-118.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Todisco, M. Effectiveness of a treatment based on melatonin in five patients with systemic sclerosis / M. Todisco // Am. J. Ther. - 2006. - Vol. 13, № 1. - P. 84-87.</mixed-citation><mixed-citation xml:lang="en">Todisco, M. Effectiveness of a treatment based on melatonin in five patients with systemic sclerosis / M. Todisco // Am. J. Ther. - 2006. - Vol. 13, № 1. - P. 84-87.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Sánchez-Barceló, E. J. Clinical uses of melatonin in pediatrics / E. J. Sánchez-Barceló, M. D. Mediavilla, R. J. Reiter // Int. J. Pediatr. - 2011. - Vol. 2011. - P. 892624.</mixed-citation><mixed-citation xml:lang="en">Sánchez-Barceló, E. J. Clinical uses of melatonin in pediatrics / E. J. Sánchez-Barceló, M. D. Mediavilla, R. J. Reiter // Int. J. Pediatr. - 2011. - Vol. 2011. - P. 892624.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
