References

zdor

Проблемы здоровья и экологии

Health and Ecology Issues

2220-09672708-6011

Gomel State Medical University

10.51523/2708-6011.2011-8-2-2

zdor-1086

Research Article

КЛИНИЧЕСКАЯ МЕДИЦИНА

CLINICAL MEDICINE

СИНДРОМ СИСТЕМНОГО ВОСПАЛИТЕЛЬНОГО ОТВЕТА И СЕПСИС У ПАЦИЕНТОВ С ЦИРРОЗОМ ПЕЧЕНИ

SYNDROME OF SYSTEMIC INFLAMMATORY RESPONSE AND SEPSIS IN PATIENTS WITH LIVER CIRRHOSIS

Малаева

Е. Г.

Malayeva

E. G.

noemail@neicon.ru

Гомельский государственный медицинский университетGomel State Medical University

2011

28062011

021319

2011

Малаева Е.Г.

Malayeva E.G.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.gsmu.by/jour/article/view/1086

Бактериальные инфекции являются частым осложнением цирроза печени, особенно у госпитализированных пациентов. Установлено, что спонтанный бактериальный перитонит и другие бактериальные инфекции у больных циррозом печени приводят к развитию синдрома системного воспалительного ответа, сепсиса и полиорганной недостаточности. В статье рассматриваются патогенез и лечение этих осложнений, роль надпочечниковой недостаточности и значение прогностических моделей интенсивной терапии.

Bacterial infections are a common liver cirrhosis complication especially in hospitalized patients. It has been established, that spontaneous bacterial peritonitis and other bacterial infections in the patients with liver cirrhosis lead to the development of syndrome of systemic inflammatory response, sepsis and multiple organ failure. In the article the pathogenesis and treatment for these complications, role of suprarenal insufficiency and value of prognostic models of intensive therapy are considered.

бактериальная инфекцияциррозбактериальная транслокациясепсиссиндром системного воспалительного ответаполиорганная недостаточностьbacterial infectioncirrhosisbacterial translocationsepsissyndrome of systemic inflammatory responsemultiple organ failure

References1

Alberti, C. Influence of systemic inflammatory response syndrome and sepsis on outcome of critically ill infected patients / C. Alberti, C. Brun-Buisson, S.V. Goodman // Am. J. Respir. Crit. Care Med. - 2003. - Vol. 168. - P. 77-84.

Annane, D. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis / D. Annane, E. Bellissant, P. E. Bollaert // BMJ. - 2004. - Vol. 329. - P. 480-489.

Antoniades, C. G. Paralysed monocytes in acute on chronic liver disease / C. G. Antoniades, J. Wendon, D. Vergani // J. Hepatol. - 2005. - Vol. 42. - P. 163-165.

Arabi, Y. Outcome predictors of cirrhosis patients admitted to the intensive care unit / Y. Arabi, Q.A. Ahmed, S. Haddad // Eur. J. Gastroenterol. Hepatol. - 2004. - Vol. 16. - P. 333-339.

Borzio, M. Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study / M. Borzio, F. Salerno, L. Piantoni // Dig. Liver Dis. - 2001. - Vol. 33. - P. 41-48.

Cholongitas, E. Risk factors, sequential organ failure assessment and model for end-stage liver disease scores for predicting short term mortality in cirrhotic patients admitted to intensive care unit / E. Cholongitas, M. Senzolo, D. Patch // Aliment. Pharmacol. Ther. - 2006. - Vol. 23. - P. 883-893.

Fasolato, S. Renal failure and bacterial infections in patients with cirrhosis: epidemiology and clinical features / S. Fasolato, P. Angeli, L. Dallagnese // Hepatology. - 2007. - Vol. 45. - P. 223-229.

Fernandez, J. Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis / J. Fernandez, M. Navasa, J. Gomez // Hepatology. - 2002. - Vol. 35. - P. 140-148.

Fernandez, J. Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis / J. Fernandez, M. Navasa, R. Planas // Gastroenterology. - 2007. - Vol. 133. - P. 818-824.

Foreman, M. G. Cirrhosis as a risk factor for sepsis and death: analysis of the national hospital discharge survey / M. G. Foreman, D. M. Mannino, M. Moss // Chest. - 2003. - Vol. 124. - P. 1016-1020.

Gustot, T. Severe sepsis in cirrhosis / T. Gustot, F. Durand, D. Lebrec // Hepatology. - 2009. - Vol. 50. - P. 2022-2033.

Kamath, P. S. A model to predict survival in patients with end-stage liver disease / P. S. Kamath, R. H. Wiesner, M. Malinchoc // Hepatology. - 2001. - Vol. 33. - P. 464-470.

Lin, C. Y. Endotoxemia contributes to the immune paralysis in patients with cirrhosis / C. Y. Lin, I. F. Tsai, Y. P. Ho // J. Hepatol. - 2007. - Vol. 46. - P. 816-826.

Matuschak, G. M. Lung-liver interactions in sepsis and multiple organ failure syndrome / G. M. Matuschak // Clin. Chest. Med. - 1996. - Vol. 17. - P. 83-98.

Plessier, A. Coagulation disorders in patients with cirrhosis and severe sepsis / A. Plessier, M.H. Denninger, Y. Consigny // Liver Int. - 2003. - Vol. 23. - P. 440-448.

Ramirez, M. J. High density lipoproteins reduce the effect of endotoxin on cytokine production and systemic hemodynamics in cirrhotic rats with ascites / M. J. Ramirez, A. Ibanez, M. Navasa // J. Hepatol. - 2004. - Vol. 40. - P. 424-430.

Ruiz-del-Arbol, L. Systemic, renal and hepatic hemodynamic derangements in cirrhotic patients with spontaneous bacterial peritonitis / L. Ruiz-del-Arbol, J. Urman, J. Fernandez // Hepatology. - 2003. - Vol. 38. - P. 1210-1218.

Salerno, F. Diagnosis, prevention and treatment of hepatorenal syndrome in cirrhosis / F. Salerno, A. Gerbes, P. Gine`s // Gut. - 2007. - Vol. 56. - P. 1310-1318.

Sanchez, W. Prevention and treatment of acute liver failure in patients with chronic liver disease / W. Sanchez, P.S. Kamath // Advances in the Therapy of Liver Diseases. - 2007. - P. 73-77.

Shawcross, D. L. Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis / D. L. Shawcross, N. A. Davies, R. Williams // J. Hepatol. - 2004. - Vol. 40. - P. 247-254.

Szabo, G. Liver in sepsis and systemic inflammatory response syndrome / G. Szabo, J. L. Romics, G. Frendl // Clin. Liver Dis. - 2002. - Vol. 6. - P. 1045-1066.

Tandon, P. Bacterial infections, sepsis, and multiorgan failure in cirrhosis / P. Tandon, G. Garcia-Tsao // Semin. Liver Dis. - 2008. - Vol. 28. - P. 26-42.

Terra, C. Renal failure in patients with cirrhosis and sepsis unrelated to spontaneous bacterial peritonitis: value of MELD score / C. Terra, M. Guevara, A. Torre // Gastroenterology. - 2005. - Vol. 129. - P. 1944-1953.

Thalheimer, U. Infection, coagulation, and variceal bleeding in cirrhosis / U. Thalheimer, C. K. Triantos, D. N. Samonakis // Gut. - 2005. - Vol. 54. - P. 556-563.

Tsai, M. H. Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock / M. H. Tsai, Y. S. Peng, Y. C. Chen // Hepatology. - 2006. - Vol. 43. - P. 673-681.

Wong, F. Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club / F. Wong, M. Bernardi, R. Balk // Gut. - 2005. - Vol. 54. - P. 718-725.

Wright, G. Endotoxemia produces coma and brain swelling in bile duct ligated rats / G. Wright, N. A. Davies, D. L. Shawcross // Hepatology. - 2007. - Vol. 45. - P. 1517-1526.

The authors declare that there are no conflicts of interest present.