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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">zdor</journal-id><journal-title-group><journal-title xml:lang="ru">Проблемы здоровья и экологии</journal-title><trans-title-group xml:lang="en"><trans-title>Health and Ecology Issues</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2220-0967</issn><issn pub-type="epub">2708-6011</issn><publisher><publisher-name>Gomel State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51523/2708-6011.2010-7-4-18</article-id><article-id custom-type="elpub" pub-id-type="custom">zdor-1015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Без раздела</subject></subj-group></article-categories><title-group><article-title>ПЕРВИЧНЫЕ ИММУНОДЕФИЦИТЫ У ВЗРОСЛЫХ: КЛИНИКО-ЛАБОРАТОРНАЯ ДИАГНОСТИКА (ЛЕКЦИЯ)</article-title><trans-title-group xml:lang="en"><trans-title>PRIMARY IMMUNODEFICIENCIES IN ADULTS: CLINICAL AND LABORATORY DIAGNOSTICS (LECTURE)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новикова</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikova</surname><given-names>I. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Гомельский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Gomel State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2010</year></pub-date><volume>0</volume><issue>4</issue><fpage>89</fpage><lpage>95</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Новикова И.А., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Новикова И.А.</copyright-holder><copyright-holder xml:lang="en">Novikova I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.gsmu.by/jour/article/view/1015">https://journal.gsmu.by/jour/article/view/1015</self-uri><abstract><p>Рассмотрены особенности клинических проявлений первичных иммунодефицитов у взрослых и современные подходы к их выявлению и идентификации. Описаны скрининговые тесты и тесты для углубленного обследования в зависимости от предполагаемого дефекта в иммунной системе.</p></abstract><trans-abstract xml:lang="en"><p>The article describes the characteristics of primary immunodeficiency clinical manifestations in adults and modern approaches for their detection and identification. Screening tests and tests for detailed examination depending on the supposed defect in the immune system are discussed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>первичный иммунодефицит у взрослых</kwd><kwd>лабораторная диагностика</kwd><kwd>primary immunodeficiency in adults</kwd><kwd>laboratory diagnostics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дранник, Г. Н. Клиническая иммунология и аллергология / Г. Н. Дранник. - М.: Медицинское информационное агентство, 2003. - 604 с.</mixed-citation><mixed-citation xml:lang="en">Дранник, Г. Н. Клиническая иммунология и аллергология / Г. Н. Дранник. - М.: Медицинское информационное агентство, 2003. - 604 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Иммунодефицитные состояния / В. С. Смирнов [и др.]; под общ. ред. В. С. Смирнова. - СПб.:Фолиант, 2000. - 568 с.</mixed-citation><mixed-citation xml:lang="en">Иммунодефицитные состояния / В. С. Смирнов [и др.]; под общ. ред. В. С. Смирнова. - СПб.:Фолиант, 2000. - 568 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ress, S. Immunodeficiency diseases presenting in adults - diagnosis and management / S. Ress// Current Allergy Clinical Immunology. - 2008. - Vol. 21, № 1. - P. 4-7.</mixed-citation><mixed-citation xml:lang="en">Ress, S. Immunodeficiency diseases presenting in adults - diagnosis and management / S. Ress// Current Allergy Clinical Immunology. - 2008. - Vol. 21, № 1. - P. 4-7.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Howard, M. Lederman The Clinical Presentation of Primary Immunodeficiency Diseases / M. Howard // Clinical Focus on Primary Immune Deficiencies. - 2000. - Vol. 2, № 1. - Р. 1-6.</mixed-citation><mixed-citation xml:lang="en">Howard, M. Lederman The Clinical Presentation of Primary Immunodeficiency Diseases / M. Howard // Clinical Focus on Primary Immune Deficiencies. - 2000. - Vol. 2, № 1. - Р. 1-6.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Identifying undiagnosed primary immunodeﬁciency diseases in minority subjects by using computer sorting of diagnosis codes / C. C. Rundles [et al.] // J Allergy Clin Immunol. - 2004. - № 113. - Р. 747-755.</mixed-citation><mixed-citation xml:lang="en">Identifying undiagnosed primary immunodeﬁciency diseases in minority subjects by using computer sorting of diagnosis codes / C. C. Rundles [et al.] // J Allergy Clin Immunol. - 2004. - № 113. - Р. 747-755.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Primary immunodeﬁciencies: 2009 update / L. D. Notarangelo [et al.] // J Allergy Clin Immunol. - 2009. - № 124. - Р. 1161-1178.</mixed-citation><mixed-citation xml:lang="en">Primary immunodeﬁciencies: 2009 update / L. D. Notarangelo [et al.] // J Allergy Clin Immunol. - 2009. - № 124. - Р. 1161-1178.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Cooper Primary Immunodeficiencies / M. A. Cooper [et al.] // American family Physician. - 2001. - Vol. 68, № 10. - P. 2001-2008.</mixed-citation><mixed-citation xml:lang="en">Cooper Primary Immunodeficiencies / M. A. Cooper [et al.] // American family Physician. - 2001. - Vol. 68, № 10. - P. 2001-2008.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Buckley, R. H. Primary cellular immunodeficiencies / R. H. Buckley // J Allergy Clin Immunol. - 2002. - № 109. - Р. 747-757.</mixed-citation><mixed-citation xml:lang="en">Buckley, R. H. Primary cellular immunodeficiencies / R. H. Buckley // J Allergy Clin Immunol. - 2002. - № 109. - Р. 747-757.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Sewell, W. A. C. Early indicators of immunodeficiency in adults and children: protocols for screening for primary immunological defects / W. A. C. Sewell, S. Khan, P. C. Dore // Clinical and Experimental Immunology. - 2006. - № 145. - P. 201-203.</mixed-citation><mixed-citation xml:lang="en">Sewell, W. A. C. Early indicators of immunodeficiency in adults and children: protocols for screening for primary immunological defects / W. A. C. Sewell, S. Khan, P. C. Dore // Clinical and Experimental Immunology. - 2006. - № 145. - P. 201-203.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Verbsky. J. W. Gellular and Genetic Basis of Primary Immune Deficiencies / J. W. Verbsky. W. J. Grossman // Pediatr Clin. - 2006. - № 53. - P. 649-684.</mixed-citation><mixed-citation xml:lang="en">Verbsky. J. W. Gellular and Genetic Basis of Primary Immune Deficiencies / J. W. Verbsky. W. J. Grossman // Pediatr Clin. - 2006. - № 53. - P. 649-684.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Vale, A. M. Clinical consequences of defects in B-cell development / A. M. Vale, H. W. Schroeder // J Allergy Clin Immunol. - 2010. - № 125. - Р. 778-787.</mixed-citation><mixed-citation xml:lang="en">Vale, A. M. Clinical consequences of defects in B-cell development / A. M. Vale, H. W. Schroeder // J Allergy Clin Immunol. - 2010. - № 125. - Р. 778-787.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Clinical and laboratory evaluation of complement deﬁciency / L. Wen [et al.] // J Allergy Clin Immunol. - 2004. - № 113. - Р. 585-593.</mixed-citation><mixed-citation xml:lang="en">Clinical and laboratory evaluation of complement deﬁciency / L. Wen [et al.] // J Allergy Clin Immunol. - 2004. - № 113. - Р. 585-593.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ballow, M. Primary immunodeficiency disorders: Antibody deficiency / M. Ballow // J Allergy clin immunol. - 2002. - Vol. 109, № 4. - Р. 581-591.</mixed-citation><mixed-citation xml:lang="en">Ballow, M. Primary immunodeficiency disorders: Antibody deficiency / M. Ballow // J Allergy clin immunol. - 2002. - Vol. 109, № 4. - Р. 581-591.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Cook, M. C. Primary immune deﬁciencies affecting lymphocyte differentiation: lessons from the spectrum of resulting infections / M. C. Cook, S. G. Tangye // International Immunology. - 2004. - Vol. 21, № 9. - P. 1003-1011.</mixed-citation><mixed-citation xml:lang="en">Cook, M. C. Primary immune deﬁciencies affecting lymphocyte differentiation: lessons from the spectrum of resulting infections / M. C. Cook, S. G. Tangye // International Immunology. - 2004. - Vol. 21, № 9. - P. 1003-1011.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Chatila, T. A. Role of regulatory T cells in human diseases / T. A. Chatila // J Allergy Clin Immunol. - 2005. - № 116. - Р. 949-959.</mixed-citation><mixed-citation xml:lang="en">Chatila, T. A. Role of regulatory T cells in human diseases / T. A. Chatila // J Allergy Clin Immunol. - 2005. - № 116. - Р. 949-959.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
